AI Portfolio Summary
In 2025 Q4, HighVista Strategies LLC maintained a portfolio of 181 distinct positions. The most significant new addition to the portfolio was TERNS PHARMACEUTICAL, which now represents 1.83% of the total fund value. Conversely, HighVista Strategies LLC completely exited their position in MERUS N V.
Total Positions
181
Quarter
2025 Q4
Top Holding
DBC (6.1%)
Top 10 Concentration
28.1%
Turnover Rate
23.4%
Sector HHI
0.18
Items per page:
1-25 of 181
| Stock | History | Sector / Type | Port % | Prev % | Rank / Prev | Conviction | Change | % Change | Influence | Shares | Mkt Value | Avg Cost | Price Held | 1st Owned | Source | Source Date | Date Reported |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
DBC
INVESCO DB COMM...
|
Unknown | 6.09% | 7.93% |
#1
Prev: #1
|
4.4 | -378,898 | -26.4% |
P
S
|
1,057,238 | $23,639,842 | 2018 Q4 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
GPCR
STRUCTURE THERA...
|
Healthcare | 3.46% | 1.62% |
#2
13
Prev: #15
|
3.4 | -43,235 | -18.3% |
P
S
|
193,001 | $13,423,219 | 2023 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
COGT
COGENT BIOSCIEN...
|
Healthcare | 3.08% | 1.63% |
#3
11
Prev: #14
|
2.2 | -125,738 | -27.2% |
P
S
|
336,667 | $11,958,412 | 2022 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
VRDN
VIRIDIAN THERAP...
|
Healthcare | 2.99% | 2.48% |
#4
Prev: #4
|
1.7 | -96,863 | -20.6% |
P
S
|
372,472 | $11,591,329 | 2022 Q1 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
ABVX
ABIVAX SA
|
Healthcare | 2.51% | 3.84% |
#5
3
Prev: #2
|
1.5 | -112,283 | -60.9% |
P
S
|
72,185 | $9,734,508 | 2024 Q1 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
RVMD
REVOLUTION MEDI...
|
Healthcare | 2.47% | 2.01% |
#6
1
Prev: #5
|
1.0 | -55,208 | -31.5% |
P
S
|
120,240 | $9,577,116 | 2021 Q1 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
PRAX
PRAXIS PRECISIO...
|
Healthcare | 1.96% | 1.23% |
#7
13
Prev: #20
|
0.8 | -69,161 | -72.8% |
P
S
|
25,841 | $7,616,376 | 2024 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
NUVL
NUVALENT INC
|
Healthcare | 1.90% | 1.98% |
#8
1
Prev: #7
|
0.8 | -20,007 | -21.4% |
P
S
|
73,287 | $7,371,939 | 2023 Q1 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
CYTK
CYTOKINETICS IN...
|
Healthcare | 1.87% | 1.79% |
#9
2
Prev: #11
|
1.2 | -18,366 | -13.8% |
P
S
|
114,564 | $7,279,396 | 2020 Q4 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
TERN
TERNS PHARMACEU...
|
Healthcare | 1.83% | — |
#10
Prev: #—
|
4.2 | 175,462 | no change |
NEW
|
175,462 | $7,088,665 | 2022 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
MAZE
MAZE THERAPEUTI...
|
Healthcare | 1.82% | — |
#11
Prev: #—
|
4.2 | 170,353 | no change |
NEW
|
170,353 | $7,057,724 | 2025 Q4 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
INSM
INSMED INC
|
Healthcare | 1.77% | 1.76% |
#12
Prev: #12
|
0.7 | -10,549 | -21.1% |
P
S
|
39,400 | $6,857,176 | 2020 Q2 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
APGE
APOGEE THERAPEU...
|
Healthcare | 1.73% | 1.04% |
#13
11
Prev: #24
|
1.2 | -17,878 | -16.7% |
P
S
|
89,229 | $6,735,005 | 2024 Q1 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
PTGX
PROTAGONIST THE...
|
Healthcare | 1.65% | 1.98% |
#14
8
Prev: #6
|
0.7 | -48,137 | -39.6% |
P
S
|
73,545 | $6,423,420 | 2021 Q2 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
SLNO
SOLENO THERAPEU...
|
Healthcare | 1.61% | 0.31% |
#15
88
Prev: #103
|
3.6 | 116,369 | 622.3% |
P
S
|
135,069 | $6,253,695 | 2024 Q1 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
SYRE
SPYRE THERAPEUT...
|
Healthcare | 1.59% | 0.89% |
#16
14
Prev: #30
|
1.1 | -27,540 | -12.8% |
P
S
|
188,206 | $6,165,629 | 2023 Q4 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
BBIO
BRIDGEBIO PHARM...
|
Healthcare | 1.58% | 1.04% |
#17
6
Prev: #23
|
1.1 | -1,754 | -2.1% |
P
S
|
80,205 | $6,134,880 | 2021 Q2 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
OLMA
OLEMA PHARMACEU...
|
Healthcare | 1.55% | 1.05% |
#18
4
Prev: #22
|
0.6 | -195,690 | -44.8% |
P
S
|
241,489 | $6,037,225 | 2021 Q1 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
IMVT
IMMUNOVANT INC
|
Healthcare | 1.45% | 1.00% |
#19
6
Prev: #25
|
1.1 | -31,244 | -12.3% |
P
S
|
221,883 | $5,640,266 | 2020 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
LQDA
LIQUIDIA CORPOR...
|
Healthcare | 1.39% | 0.98% |
#20
8
Prev: #28
|
1.1 | -20,482 | -11.6% |
P
S
|
156,003 | $5,380,543 | 2024 Q2 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
PCVX
VAXCYTE INC
|
Healthcare | 1.36% | 0.77% |
#21
17
Prev: #38
|
3.0 | 27,247 | 31.4% |
P
S
|
114,049 | $5,262,221 | 2022 Q2 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
CDTX
CIDARA THERAPEU...
|
Healthcare | 1.30% | 1.66% |
#22
9
Prev: #13
|
0.5 | -47,976 | -67.7% |
P
S
|
22,928 | $5,064,566 | 2025 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
ACLX
ARCELLX INC
|
Healthcare | 1.26% | 1.94% |
#23
14
Prev: #9
|
0.5 | -21,175 | -22.0% |
P
S
|
75,002 | $4,890,130 | 2023 Q1 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
RLAY
RELAY THERAPEUT...
|
Healthcare | 1.19% | 0.31% |
#24
80
Prev: #104
|
3.5 | 304,620 | 126.7% |
P
S
|
545,079 | $4,611,368 | 2020 Q4 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
RYTM
RHYTHM PHARMACE...
|
Healthcare | 1.18% | 0.93% |
#25
4
Prev: #29
|
2.5 | 5,385 | 14.4% |
P
S
|
42,867 | $4,588,483 | 2020 Q2 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
MRUS
MERUS N V
|
Healthcare | 0.00% | 3.08% |
Sold All 😨
(Was: #3) |
0.0 | -133,321 | -100.0% |
CLOSED
|
— | $— | 2021 Q4 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
AKRO
AKERO THERAPEUT...
|
Healthcare | 0.00% | 1.28% |
Sold All 😨
(Was: #19) |
0.0 | -110,079 | -100.0% |
CLOSED
|
— | $— | 2020 Q4 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
XENE
XENON PHARMACEU...
|
Healthcare | 0.00% | 0.81% |
Sold All 😨
(Was: #36) |
0.0 | -82,190 | -100.0% |
CLOSED
|
— | $— | 2020 Q2 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
AMD
ADVANCED MICRO ...
|
Technology | 0.00% | 0.68% |
Sold All 😨
(Was: #42) |
0.0 | -17,200 | -100.0% |
CLOSED
|
— | $— | 2024 Q1 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
VERA
VERA THERAPEUTI...
|
Healthcare | 0.00% | 0.65% |
Sold All 😨
(Was: #46) |
0.0 | -91,189 | -100.0% |
CLOSED
|
— | $— | 2023 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
CRH
CRH PLC
|
Basic Materials | 0.00% | 0.57% |
Sold All 😨
(Was: #52) |
0.0 | -19,439 | -100.0% |
CLOSED
|
— | $— | 2024 Q1 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
SRRK
SCHOLAR ROCK HL...
|
Healthcare | 0.00% | 0.54% |
Sold All 😨
(Was: #53) |
0.0 | -59,573 | -100.0% |
CLOSED
|
— | $— | 2025 Q1 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
PWR
QUANTA SVCS INC
|
Industrials | 0.00% | 0.53% |
Sold All 😨
(Was: #56) |
0.0 | -5,200 | -100.0% |
CLOSED
|
— | $— | 2025 Q1 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
AVTR
AVANTOR INC
|
Healthcare | 0.00% | 0.53% |
Sold All 😨
(Was: #57) |
0.0 | -172,400 | -100.0% |
CLOSED
|
— | $— | 2025 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
COF
CAPITAL ONE FIN...
|
Financial Services | 0.00% | 0.50% |
Sold All 😨
(Was: #62) |
0.0 | -9,674 | -100.0% |
CLOSED
|
— | $— | 2013 Q4 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
DVAX
DYNAVAX TECHNOL...
|
Healthcare | 0.00% | 0.47% |
Sold All 😨
(Was: #67) |
0.0 | -192,849 | -100.0% |
CLOSED
|
— | $— | 2020 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
FN
FABRINET
|
Technology | 0.00% | 0.46% |
Sold All 😨
(Was: #69) |
0.0 | -5,100 | -100.0% |
CLOSED
|
— | $— | 2025 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
WDC
WESTERN DIGITAL...
|
Technology | 0.00% | 0.42% |
Sold All 😨
(Was: #73) |
0.0 | -14,242 | -100.0% |
CLOSED
|
— | $— | 2011 Q2 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
STX
SEAGATE TECHNOL...
|
Technology | 0.00% | 0.40% |
Sold All 😨
(Was: #77) |
0.0 | -6,898 | -100.0% |
CLOSED
|
— | $— | 2014 Q2 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
CNM
CORE & MAIN INC
|
Industrials | 0.00% | 0.37% |
Sold All 😨
(Was: #81) |
0.0 | -27,900 | -100.0% |
CLOSED
|
— | $— | 2025 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
ROIV
ROIVANT SCIENCE...
|
Healthcare | 0.00% | 0.37% |
Sold All 😨
(Was: #82) |
0.0 | -98,858 | -100.0% |
CLOSED
|
— | $— | 2023 Q4 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
CRBP
CORBUS PHARMACE...
|
Healthcare | 0.00% | 0.37% |
Sold All 😨
(Was: #83) |
0.0 | -118,027 | -100.0% |
CLOSED
|
— | $— | 2019 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
CSCO
CISCO SYS INC
|
Technology | 0.00% | 0.37% |
Sold All 😨
(Was: #84) |
0.0 | -21,800 | -100.0% |
CLOSED
|
— | $— | 2010 Q4 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
ENTG
ENTEGRIS INC
|
Technology | 0.00% | 0.36% |
Sold All 😨
(Was: #87) |
0.0 | -15,700 | -100.0% |
CLOSED
|
— | $— | 2015 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
BAC
BANK AMERICA CO...
|
Financial Services | 0.00% | 0.35% |
Sold All 😨
(Was: #90) |
0.0 | -27,500 | -100.0% |
CLOSED
|
— | $— | 2017 Q1 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
ADMA
ADMA BIOLOGICS ...
|
Healthcare | 0.00% | 0.34% |
Sold All 😨
(Was: #92) |
0.0 | -95,112 | -100.0% |
CLOSED
|
— | $— | 2025 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
EOLS
EVOLUS INC
|
Healthcare | 0.00% | 0.34% |
Sold All 😨
(Was: #93) |
0.0 | -226,025 | -100.0% |
CLOSED
|
— | $— | 2025 Q2 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
PGR
PROGRESSIVE COR...
|
Financial Services | 0.00% | 0.33% |
Sold All 😨
(Was: #96) |
0.0 | -5,500 | -100.0% |
CLOSED
|
— | $— | 2015 Q4 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
KROS
KEROS THERAPEUT...
|
Healthcare | 0.00% | 0.32% |
Sold All 😨
(Was: #101) |
0.0 | -83,050 | -100.0% |
CLOSED
|
— | $— | 2022 Q1 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
JCI
JOHNSON CTLS IN...
|
Industrials | 0.00% | 0.30% |
Sold All 😨
(Was: #107) |
0.0 | -11,100 | -100.0% |
CLOSED
|
— | $— | 2025 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
CZR
CAESARS ENTERTA...
|
Consumer Cyclical | 0.00% | 0.28% |
Sold All 😨
(Was: #112) |
0.0 | -43,000 | -100.0% |
CLOSED
|
— | $— | 2020 Q2 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
NTRA
NATERA INC
|
Healthcare | 0.00% | 0.26% |
Sold All 😨
(Was: #117) |
0.0 | -6,580 | -100.0% |
CLOSED
|
— | $— | 2021 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
MAGN
MAGNERA CORP
|
Consumer Defensive | 0.00% | 0.25% |
Sold All 😨
(Was: #120) |
0.0 | -87,100 | -100.0% |
CLOSED
|
— | $— | 2025 Q1 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
BABA
ALIBABA GROUP H...
|
Consumer Cyclical | 0.00% | 0.16% |
Sold All 😨
(Was: #136) |
0.0 | -3,757 | -100.0% |
CLOSED
|
— | $— | 2014 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
NBIS
NEBIUS GROUP N....
|
Communication Services | 0.00% | 0.14% |
Sold All 😨
(Was: #138) |
0.0 | -5,200 | -100.0% |
CLOSED
|
— | $— | 2018 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
WVE
WAVE LIFE SCIEN...
|
Healthcare | 0.00% | 0.11% |
Sold All 😨
(Was: #141) |
0.0 | -59,261 | -100.0% |
CLOSED
|
— | $— | 2025 Q1 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
INBX
INHIBRX BIOSCIE...
|
Healthcare | 0.00% | 0.06% |
Sold All 😨
(Was: #144) |
0.0 | -7,626 | -100.0% |
CLOSED
|
— | $— | 2025 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
TAL
TAL EDUCATION G...
|
Consumer Defensive | 0.00% | 0.05% |
Sold All 😨
(Was: #145) |
0.0 | -19,600 | -100.0% |
CLOSED
|
— | $— | 2023 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
BEKE
KE HLDGS INC
|
Real Estate | 0.00% | 0.05% |
Sold All 😨
(Was: #146) |
0.0 | -11,400 | -100.0% |
CLOSED
|
— | $— | 2023 Q1 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
AURA
AURA BIOSCIENCE...
|
Healthcare | 0.00% | 0.04% |
Sold All 😨
(Was: #147) |
0.0 | -27,174 | -100.0% |
CLOSED
|
— | $— | 2025 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
MLTX
MOONLAKE IMMUNO...
|
Healthcare | 0.00% | 0.03% |
Sold All 😨
(Was: #148) |
0.0 | -19,059 | -100.0% |
CLOSED
|
— | $— | 2023 Q1 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) |
Showing 1-25 of 181 holdings