Stock Analysis
Data Source: SEC EDGAR 13F
Updated Hourly

SPYRE THERAPEUTICS INC (SYRE)

147 + Investors. Track Smart Money conviction in SYRE. See who's accumulating, reducing, or initiating positions.

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Current Price
-- USD
Analyst Target
-- (0 analysts)
Upside
0.00%
Net Flow Q/Q
↑ +16
Streak
2Q ▲
Buyers last Q
72%

Smart Money Signals — SYRE

Based on 144 hedge funds · latest filing: 2025 Q4 · updated quarterly

📈

Buying streak — 2 quarters in a row

last 6Q
For 2 consecutive quarters, more hedge funds added SYRE than sold it. That's a consistent pattern of professional buying — not a one-time trade. When institutions keep buying quarter after quarter, it usually means they see a multi-year opportunity, not just a short-term momentum flip.
🏔️

At the ownership peak (100% of max)

100% of all-time peak
144 hedge funds hold SYRE right now — the highest count in 3.0 years. When ownership is this concentrated, any bad news can trigger a chain reaction: one big fund sells, others follow. This is a classic 'crowded trade' — high popularity doesn't equal safety.
📶

Steady growth — +16% more funds vs a year ago

fund count last 6Q
+20 new funds entered over the past year (+16% YoY). Gradual, steady growth in institutional ownership is generally a healthy signal — not a speculative rush, but consistent conviction.
🟢

More buyers than sellers — 72% buying

102 buying40 selling
Last quarter: 102 funds were net buyers (30 opened a brand new position + 72 added to an existing one). Only 40 were sellers (26 trimmed + 14 sold completely). A clear majority buying is a strong confirmation signal.
📈

More new buyers each quarter (+11 vs last Q)

new funds entering per quarter
Funds opening a new SYRE position: 21 → 18 → 19 → 30. A growing influx of new institutional buyers means the asset is still gathering momentum — the consensus hasn't fully saturated yet.
🔄

Mostly new holders — 24% entered in last year

24% conviction (2yr+) 51% medium 24% new
Only 35 funds (24%) have held >2 years. The majority of current holders are relatively new to the position. New holders tend to sell faster when prices drop — a shallow conviction base that could amplify any sell-off.
💰

Value +144% but shares only +26% — price-driven

Value
+144%
Shares
+26%
Last quarter: the total dollar value of institutional holdings rose +144%, but actual share count only changed +26%. The gap is explained by the stock's price rising — not new buying. Strong value growth with weak share growth means the rally is price momentum, not fresh institutional demand.
📈

Growing discovery — still being found

30 → 21 → 18 → 19 → 30 new funds/Q
New funds entering each quarter: 21 → 18 → 19 → 30. A growing number of institutions are discovering SYRE each quarter. The narrative is still spreading — leaving room for ongoing capital accumulation.
📊

Mixed cohorts — 18% veterans, 37% new entrants

18% veterans 45% 1-2yr 37% new
Of 147 current holders: 27 (18%) held 2+ years, 66 held 1–2 years, 54 (37%) entered in the past year. Balanced distribution — some institutional memory, some recent momentum buyers.
🏆

Elite ownership — 40% AUM from top-100 funds

40% from top-100 AUM funds
31 of 144 holders are among the 100 largest funds by AUM, controlling 40% of total institutional value in SYRE. When the biggest players dominate the cap table, it signifies deep institutional support — since mega-funds deploy the most rigorous due diligence and capital.
3.8
out of 10
Low Exit Risk
Exit risk score 3.8/10 — low institutional crowding. Ownership is below peak levels, holder base is relatively sticky, and buying momentum is positive.

Methodology note: these Smart Money cards use consecutive 13F disclosure snapshots, not trade-by-trade execution data. "Buying", "selling", "new holders", and "trimmed" refer to quarter-over-quarter changes in reported holders, aggregate shares, or disclosed position values between filings. They are useful for ownership regime analysis and crowding, but they do not imply exact trade timing on the filing date.

Hedge Fund Ownership: SYRE

How many hedge funds hold SYRE — quarterly history vs. share price
Quarterly hedge fund ownership of SYRE vs. share price

Market Analysis: SYRE

Analyst Price Targets

Avg. Price Target
--

Analyst Recommendations

Stock Performance

Real-time

Company Profile: SYRE

-- --
Smart Money Signal ?
Limited Smart Money Interest

No strong consensus or elite conviction detected among institutional holders.

34 top-rated funds 5 high-conviction
Consensus
6.7
/ 10
breadth
×
Elite
3.1
/ 10
conviction
Hedge Fund Positioning: SYRE
2026 Q1 Stats Unlock in 16 days 147 + Investors

Track Smart Money conviction in SYRE. See who's accumulating, reducing, or initiating positions.

Metric All 13F Filers (2025 Q4) Prior (2025 Q3) Change
Funds Holding 147 129 13.95%
13F Shares 81M 64M 26.37%
Total Value $2.61B $1.07B 144.49%
New Positions 33 19 +14
Increased Positions 73 42 +31
Closed Positions 14 15 -1
Reduced Positions 26 44 -18
Total Calls 2 1 100.0%
Total Puts 2 1 100.0%
PUT/CALL Ratio 1.0 1.0 Neutral

Statistics: SYRE

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Valuation Measures Data as of: --

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PEG Ratio (5yr expected) --
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Enterprise Value/EBITDA --
Beta (5Y Monthly) --
Short Ratio (Days to Cover) --
Short % of Float --

Financial Highlights

Profitability
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Return on Assets (ttm) --
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Income Statement & Cash Flow
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Institutional Holders (2026 Q1)

147 + investors

Explore institutional interest and hedge fund ownership dynamics. Analyze portfolio weights, new positions, and conviction trends in SYRE. Verified SEC 13F-HR filings.

Top 25 institutional holders of SYRE — 2025 Q4 · Source: SEC Form 13F
# Investor % of Portfolio Shares Mkt Value
1 Ellsworth Advisors, LLC 0.21% 21,963 $1.1M
2 PSP Research LLC 0.18% 5,159 $260K
3 Candriam S.C.A. 0.16% 610,282 $30.8M
4 High Net Worth Advisory Group LLC 0.07% 6,000 $303K
5 China Universal Asset Management Co., Ltd. 0.05% 13,938 $703K
6 PROFUND ADVISORS LLC 0.05% 26,043 $1.3M
7 Pictet Asset Management Holding SA 0.03% 491,649 $24.8M
8 RWC Asset Management LLP 0.02% 8,166 $412K
9 E Fund Management Co., Ltd. 0.01% 7,156 $361K
10 Police & Firemen's Retirement System of New Jersey 0.01% 18,360 $926K
11 AlphaQuest LLC 0.01% 3,538 $116K
12 Arizona State Retirement System 0.00% 13,438 $678K
13 SUMMIT SECURITIES GROUP LLC 0.00% 562 $28K
14 Union Bancaire Privee, UBP SA 0.00% 3,880 $159K
15 KLP KAPITALFORVALTNING AS 0.00% 10,900 $550K
16 GF FUND MANAGEMENT CO. LTD. 0.00% 1,743 $88K
17 Assenagon Asset Management S.A. 0.00% 18,647 $941K
18 TEACHER RETIREMENT SYSTEM OF TEXAS 0.00% 6,280 $317K
19 GAMMA Investing LLC 0.00% 523 $26K
20 ProShare Advisors LLC 0.00% 13,498 $681K
21 Sterling Capital Management LLC 0.00% 1,051 $53K
22 STRS OHIO 0.00% 4,500 $227K
23 SG Americas Securities, LLC 0.00% 13,396
24 NISA INVESTMENT ADVISORS, LLC 0.00% 1,916 $97K
25 SIGNATUREFD, LLC 0.00% 70 $4K
Investor Ownership
History
% of Portfolio Prev % Rank Conviction Avg Buy Price 13F Score™ 3Y / 7Y Sell Timing Shares Mkt Value Change Change % Source Quarter Filed

Frequently Asked Questions — SPYRE THERAPEUTICS INC (SYRE)

What does the Smart Money Trend signal show for SYRE?

Buying streak — 2 quarters in a row: For 2 consecutive quarters, more hedge funds added SYRE than sold it. That's a consistent pattern of professional buying — not a one-time trade. When institutions keep buying quarter after quarter, it usually means they see a multi-year opportunity, not just a short-term momentum flip.

What is the institutional breadth score for SYRE?

More buyers than sellers — 72% buying: Last quarter: 102 funds were net buyers (30 opened a brand new position + 72 added to an existing one). Only 40 were sellers (26 trimmed + 14 sold completely). A clear majority buying is a strong confirmation signal.

What is the fund quality score for SYRE holders?

Elite ownership — 40% AUM from top-100 funds: 31 of 144 holders are among the 100 largest funds by AUM, controlling 40% of total institutional value in SYRE. When the biggest players dominate the cap table, it signifies deep institutional support — since mega-funds deploy the most rigorous due diligence and capital.

How long have hedge funds held SYRE?

Mostly new holders — 24% entered in last year: Only 35 funds (24%) have held >2 years. The majority of current holders are relatively new to the position. New holders tend to sell faster when prices drop — a shallow conviction base that could amplify any sell-off.

Where does this institutional ownership data come from?

All holdings data is sourced from SEC Form 13F filings, which institutional investment managers with over $100 million in assets are required to submit quarterly. Data is parsed directly from SEC EDGAR.

Disclaimer: The information on this page is for informational purposes only and does not constitute investment advice, a recommendation, or an offer to buy or sell any security. Institutional holdings data is sourced from SEC Form 13F filings and reflects positions as of the filing date. Past performance of any fund or portfolio is not indicative of future results. 13Foresight is not a registered investment adviser. Always conduct your own due diligence before making investment decisions.