Stock Analysis
Data Source: SEC EDGAR 13F
Updated Hourly

Spyre Therapeutics Inc (SYRE)

258 + Investors. Track Smart Money conviction in SYRE. See who's accumulating, reducing, or initiating positions.

Current Price
-- USD
Analyst Target
-- (0 analysts)
Upside
0.00%
Net Flow Q/Q
↑ +66
Streak
5Q ▲
Buyers last Q
70%

Smart Money Signals — SYRE

Based on 261 hedge funds · latest filing: 2026 Q2 · updated quarterly

📈

Buying streak — 5 quarters in a row

last 6Q
For 5 consecutive quarters, more hedge funds added SYRE than sold it. That's a consistent pattern of professional buying — not a one-time trade. When institutions keep buying quarter after quarter, it usually means they see a multi-year opportunity, not just a short-term momentum flip.
🏔️

At the ownership peak (100% of max)

100% of all-time peak
261 hedge funds hold SYRE right now — the highest count in 3.0 years. When ownership is this concentrated, any bad news can trigger a chain reaction: one big fund sells, others follow. This is a classic 'crowded trade' — high popularity doesn't equal safety.
🚀

Fast accumulation — +101% more funds vs a year ago

fund count last 6Q
+131 new funds entered over the past year (+101% YoY). That's a rapid rush of institutional money. Fast accumulation often signals a major thesis — but it also means the stock could fall quickly if that thesis breaks.
🟢

More buyers than sellers — 70% buying

191 buying83 selling
Last quarter: 191 funds were net buyers (91 opened a brand new position + 100 added to an existing one). Only 83 were sellers (58 trimmed + 25 sold completely). A clear majority buying is a strong confirmation signal.
📈

More new buyers each quarter (+35 vs last Q)

new funds entering per quarter
Funds opening a new SYRE position: 20 → 31 → 56 → 91. A growing influx of new institutional buyers means the asset is still gathering momentum — the consensus hasn't fully saturated yet.
🔄

Mostly new holders — 50% entered in last year

■ 23% conviction (2yr+) ■ 28% medium ■ 50% new
Only 59 funds (23%) have held >2 years. The majority of current holders are relatively new to the position. New holders tend to sell faster when prices drop — a shallow conviction base that could amplify any sell-off.
💰

Value +105% but shares only +24% — price-driven

Value
+105%
Shares
+23%
Last quarter: the total dollar value of institutional holdings rose +105%, but actual share count only changed +24%. The gap is explained by the stock's price rising — not new buying. Strong value growth with weak share growth means the rally is price momentum, not fresh institutional demand.
🚀

Acceleration phase — new buyers rushing in

19 → 20 → 31 → 56 → 91 new funds/Q
New funds entering each quarter: 20 → 31 → 56 → 91. The pace of institutional discovery is accelerating sharply. This is the 'hot idea' phase — the thesis is being passed from fund to fund. You are not late — the accumulation wave is still building.
📊

Mixed cohorts — 28% veterans, 49% new entrants

■ 28% veterans ■ 23% 1-2yr ■ 49% new
Of 269 current holders: 74 (28%) held 2+ years, 63 held 1–2 years, 132 (49%) entered in the past year. Balanced distribution — some institutional memory, some recent momentum buyers.
🏆

Elite ownership — 47% AUM from top-100 funds

47% from top-100 AUM funds
54 of 261 holders are among the 100 largest funds by AUM, controlling 47% of total institutional value in SYRE. When the biggest players dominate the cap table, it signifies deep institutional support — since mega-funds deploy the most rigorous due diligence and capital.
5.5
out of 10
Moderate Exit Risk
Exit risk score 5.5/10 — some crowding factors present, but no critical concentration. Watch ownership trend over the next 1–2 quarters for direction.

Methodology note: these Smart Money cards use consecutive 13F disclosure snapshots, not trade-by-trade execution data. "Buying", "selling", "new holders", and "trimmed" refer to quarter-over-quarter changes in reported holders, aggregate shares, or disclosed position values between filings. They are useful for ownership regime analysis and crowding, but they do not imply exact trade timing on the filing date.

Institutional Sentiment Summary — SYRE

In 2026 Q2, 191 hedge funds were net buyers of SYRE (91 opened a new position, 100 added to an existing one), while 83 reduced or exited (58 trimmed, 25 sold completely) — a 70% buyer ratio, indicating clear institutional accumulation. This marks 5 consecutive quarters of net institutional buying — a persistent conviction signal. 47% of total institutional value in SYRE is held by top-100 AUM funds, reflecting elite-tier ownership quality. Net fund flow last quarter: +66 funds (more new holders than closures). Total institutional holders: 261.

Hedge Fund Ownership: SYRE

How many hedge funds hold SYRE — quarterly history vs. share price
Quarterly hedge fund ownership of SYRE vs. share price

Market Analysis: SYRE

Analyst Price Targets

Avg. Price Target
--

Analyst Recommendations

Stock Performance

Real-time

Company Profile: SYRE

-- --

Institutional ownership data sourced from SEC EDGAR Form 13F-HR filings.

Loading signal freshness…
Smart Money Signal ?
Limited Smart Money Interest

No strong consensus or elite conviction detected among institutional holders.

16 top-rated funds 9 high-conviction
Consensus
5.3
/ 10
breadth
×
Elite
4.3
/ 10
conviction
Hedge Fund Positioning: SYRE
258 + Investors

Track Smart Money conviction in SYRE. See who's accumulating, reducing, or initiating positions.

Metric All 13F Filers (2026 Q2) Prior (2026 Q1) Change
Funds Holding 258 195 32.31%
13F Shares 96M 82M 16.73%
Total Value $8.28B $4.07B 103.34%
New Positions 90 56 +34
Increased Positions 98 66 +32
Closed Positions 27 12 +15
Reduced Positions 56 49 +7
Total Calls 4 2 100.0%
Total Puts 4 2 100.0%
PUT/CALL Ratio 1.0 1.0 Neutral

Statistics: SYRE

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Financial Highlights

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Institutional Holders (2026 Q2)

258 + investors

Explore institutional interest and hedge fund ownership dynamics. Analyze portfolio weights, new positions, and conviction trends in SYRE. Verified SEC 13F-HR filings.

QUARTER:
Top 25 SYRE holders by conviction (% of portfolio weight) — 2026 Q2 · Source: SEC Form 13F
# Investor % of Portfolio Shares Mkt Value
1 Remedium Capital Partners, LLC 28.78% 1,464,169 $130.0M
2 Venrock Adviser, LLC 8.04% 2,985,448 $265.0M
3 Tang Capital Management LLC 7.63% 1,892,200 $168.0M
4 Monashee Investment Management LLC 7.45% 50,000 $4.4M
5 Paradigm Biocapital Advisors LP 6.38% 3,840,778 $341.0M
6 Perceptive Advisors LLC 5.76% 4,319,496 $383.5M
7 Affinity Asset Advisors, LLC 5.13% 1,279,134 $113.6M
8 Commodore Capital LP 4.48% 846,786 $75.2M
9 TCG Crossover Management, LLC 4.06% 1,900,582 $168.7M
10 Rtw Investments, LP 3.22% 4,251,996 $377.5M
11 B Group, Inc. 2.92% 70,000 $6.2M
12 Braidwell LP 2.89% 879,467 $78.1M
13 Siren, L.L.C. 1.74% 968,598 $86.0M
14 Stempoint Capital LP 1.64% 106,926 $9.5M
15 HighVista Strategies LLC 1.57% 77,807 $6.9M
16 Driehaus Capital Management LLC 1.44% 2,799,166 $248.5M
17 Atle Fund Management AB 1.36% 57,030 $5.1M
18 Emerald Mutual Fund Advisers Trust 1.25% 401,271 $35.6M
19 Emerald Advisers, LLC 1.19% 567,430 $50.4M
20 ADAR1 Capital Management, LLC 1.15% 283,982 $25.2M
21 Integral Health Asset Management, LLC 1.14% 325,000 $28.9M
22 Cormorant Asset Management, LP 1.02% 225,000 $20.0M
23 Rhenman & Partners Asset Management AB 1.00% 119,300 $10.6M
24 Seven Grand Managers, LLC 0.80% 225,000 $20.0M
25 Moody Aldrich Partners LLC 0.68% 42,458 $3.8M
Investor Ownership
History 		% of Portfolio Prev % Rank Conviction Avg Buy Price 13F Score™ 3Y / 7Y Sell Timing Shares Mkt Value Change Change % Source Quarter Filed

Frequently Asked Questions — Spyre Therapeutics Inc (SYRE)

What does the Smart Money Trend signal show for SYRE?

Buying streak — 5 quarters in a row: For 5 consecutive quarters, more hedge funds added SYRE than sold it. That's a consistent pattern of professional buying — not a one-time trade. When institutions keep buying quarter after quarter, it usually means they see a multi-year opportunity, not just a short-term momentum flip.

What is the institutional breadth score for SYRE?

More buyers than sellers — 70% buying: Last quarter: 191 funds were net buyers (91 opened a brand new position + 100 added to an existing one). Only 83 were sellers (58 trimmed + 25 sold completely). A clear majority buying is a strong confirmation signal.

What is the fund quality score for SYRE holders?

Elite ownership — 47% AUM from top-100 funds: 54 of 261 holders are among the 100 largest funds by AUM, controlling 47% of total institutional value in SYRE. When the biggest players dominate the cap table, it signifies deep institutional support — since mega-funds deploy the most rigorous due diligence and capital.

How long have hedge funds held SYRE?

Mostly new holders — 50% entered in last year: Only 59 funds (23%) have held >2 years. The majority of current holders are relatively new to the position. New holders tend to sell faster when prices drop — a shallow conviction base that could amplify any sell-off.

Where does this institutional ownership data come from?

All holdings data is sourced from SEC Form 13F filings, which institutional investment managers with over $100 million in assets are required to submit quarterly. Data is parsed directly from SEC EDGAR.

Disclaimer: The information on this page is for informational purposes only and does not constitute investment advice, a recommendation, or an offer to buy or sell any security. Institutional holdings data is sourced from SEC Form 13F filings and reflects positions as of the filing date. Past performance of any fund or portfolio is not indicative of future results. 13Foresight is not a registered investment adviser. Always conduct your own due diligence before making investment decisions.

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