BAKER BROS. ADVISORS LP

All Holdings — 2025 Q4

AI Portfolio Summary
In 2025 Q4, BAKER BROS. ADVISORS LP maintained a portfolio of 99 distinct positions. They heavily accumulated shares in Incyte Corporation, increasing their position by 0.0%. Conversely, BAKER BROS. ADVISORS LP completely exited their position in Merus N.V..
PCA Score Concentration Risk
Risk ENB
Total Positions
99
Quarter
2025 Q4
Top Holding
INCY (17.8%)
Top 10 Concentration
74.4%
Turnover Rate
23.4%
Sector HHI
0.18
Items per page:
1-25 of 99
Stock History Sector / Type Port % Prev % Rank / Prev Conviction Change % Change Influence Shares Mkt Value Avg Cost Price Held 1st Owned Source Source Date Date Reported
INCY
Incyte Corporat...
Healthcare 17.78% 18.84% #1 1
Prev: #2
9.1 328 0.0%
P
S
30,743,991 $3,036,583,991 2003 Q2 13F Filing 2025-12-31 2026-02-14 (Est.)
ONC
BeOne Medicines...
Healthcare 15.65% 21.66% #2 1
Prev: #1
6.3 no change no change
P
S
8,799,053 $2,673,240,292 2016 Q1 13F Filing 2025-12-31 2026-02-14 (Est.)
MDGL
Madrigal Pharma...
Healthcare 7.30% 7.10% #3
Prev: #3
2.9 no change no change
P
S
2,141,701 $1,247,198,160 2016 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
INSM
Insmed Incorpor...
Healthcare 6.72% 6.98% #4
Prev: #4
2.7 -110,738 -1.7%
P
S
6,592,746 $1,147,401,514 2012 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
ACAD
ACADIA Pharmace...
Healthcare 6.71% 6.61% #5
Prev: #5
2.7 no change no change
P
S
42,896,690 $1,145,770,590 2005 Q1 13F Filing 2025-12-31 2026-02-14 (Est.)
CELC
Celcuity Inc.
Healthcare 4.62% 2.83% #6 3
Prev: #9
1.8 no change no change
P
S
7,915,792 $789,521,094 2023 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
RVMD
Revolution Medi...
Healthcare 4.41% 3.19% #7 1
Prev: #8
1.8 no change no change
P
S
9,455,357 $753,119,185 2021 Q1 13F Filing 2025-12-31 2026-02-14 (Est.)
KYMR
Kymera Therapeu...
Healthcare 3.94% 2.72% #8 2
Prev: #10
3.7 2,005,813 30.2%
P
S
8,657,242 $673,620,000 2020 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
SMMT
Summit Therapeu...
Healthcare 3.73% 5.03% #9 3
Prev: #6
3.5 2,668,089 7.9%
P
S
36,391,063 $636,479,692 2022 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
RYTM
Rhythm Pharmace...
Healthcare 3.51% 4.09% #10 3
Prev: #7
1.4 no change no change
P
S
5,604,483 $599,903,860 2017 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
KOD
Kodiak Sciences...
Healthcare 3.26% 2.05% #11
Prev: #11
3.3 2,608,696 15.1%
P
S
19,919,186 $556,940,441 2018 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
PRAX
Praxis Precisio...
Healthcare 1.94% 0.26% #12 24
Prev: #36
3.0 437,000 63.4%
P
S
1,126,488 $332,021,073 2024 Q1 13F Filing 2025-12-31 2026-02-14 (Est.)
ALKS
Alkermes plc
Healthcare 1.64% 1.75% #13 1
Prev: #12
2.7 1,920,916 23.7%
P
S
10,012,267 $280,143,231 2003 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
GRAL
GRAIL, Inc.
Healthcare 1.05% 0.70% #14 4
Prev: #18
2.5 455,208 27.9%
P
S
2,085,333 $178,483,651 2024 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
EWTX
Edgewise Therap...
Healthcare 0.96% 0.86% #15 1
Prev: #14
0.4 -730,000 -10.0%
P
S
6,575,940 $163,181,951 2021 Q1 13F Filing 2025-12-31 2026-02-14 (Est.)
ARWR
Arrowhead Pharm...
Healthcare 0.85% 0.42% #16 9
Prev: #25
2.4 504,883 30.2%
P
S
2,175,645 $144,441,072 2013 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
IONS
Ionis Pharmaceu...
Healthcare 0.83% 0.27% #17 18
Prev: #35
2.6 1,225,043 216.1%
P
S
1,791,841 $141,752,542 2006 Q2 13F Filing 2025-12-31 2026-02-14 (Est.)
IMVT
Immunovant, Inc...
Healthcare 0.81% 0.64% #18 2
Prev: #20
0.3 no change no change
P
S
5,457,881 $138,739,335 2023 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
IMTX
Immatics N.V.
Healthcare 0.74% 0.74% #19 2
Prev: #17
0.3 no change no change
P
S
12,094,094 $126,987,987 2020 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
IDYA
IDEAYA Bioscien...
Healthcare 0.73% 0.64% #20 1
Prev: #19
2.3 343,382 10.5%
P
S
3,618,826 $125,102,815 2019 Q2 13F Filing 2025-12-31 2026-02-14 (Est.)
ROIV
Roivant Science...
Healthcare 0.71% 0.41% #21 5
Prev: #26
2.4 1,787,244 47.4%
P
S
5,555,017 $120,543,869 2022 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
ABVX
Abivax S.A.
Healthcare 0.69% 0.54% #22 2
Prev: #24
0.3 no change no change
P
S
875,796 $118,105,470 2025 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
KNSA
Kiniksa Pharmac...
Healthcare 0.68% 0.79% #23 8
Prev: #15
2.3 1,577 0.1%
P
S
2,826,246 $116,582,648 2024 Q2 13F Filing 2025-12-31 2026-02-14 (Est.)
REPL
Replimune Group...
Healthcare 0.63% 0.33% #24 6
Prev: #30
0.3 no change no change
P
S
11,045,336 $107,360,666 2020 Q2 13F Filing 2025-12-31 2026-02-14 (Est.)
STOK
Stoke Therapeut...
Healthcare 0.62% 0.79% #25 9
Prev: #16
0.3 -1,297,141 -28.0%
P
S
3,336,697 $105,906,763 2022 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
MRUS
Merus N.V.
Healthcare 0.00% 0.39%
Sold All 😨
(Was: #28)
0.3 -574,377 -100.0%
CLOSED
$— 2016 Q2 13F Filing 2025-12-31 2026-02-14 (Est.)
NTLA
Intellia Therap...
Healthcare 0.00% 0.34%
Sold All 😨
(Was: #29)
0.3 -2,746,674 -100.0%
CLOSED
$— 2016 Q2 13F Filing 2025-12-31 2026-02-14 (Est.)
RNA
Avidity Bioscie...
Healthcare 0.00% 0.20%
Sold All 😨
(Was: #43)
0.3 -625,000 -100.0%
CLOSED
$— 2022 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
PCVX
Vaxcyte, Inc.
Healthcare 0.00% 0.17%
Sold All 😨
(Was: #44)
0.3 -640,885 -100.0%
CLOSED
$— 2022 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
CDTX
Cidara Therapeu...
Healthcare 0.00% 0.16%
Sold All 😨
(Was: #46)
0.3 -227,272 -100.0%
CLOSED
$— 2025 Q2 13F Filing 2025-12-31 2026-02-14 (Est.)
AKRO
Akero Therapeut...
Healthcare 0.00% 0.11%
Sold All 😨
(Was: #52)
0.3 -324,630 -100.0%
CLOSED
$— 2020 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
ACLX
Arcellx, Inc.
Healthcare 0.00% 0.10%
Sold All 😨
(Was: #56)
0.3 -166,825 -100.0%
CLOSED
$— 2025 Q2 13F Filing 2025-12-31 2026-02-14 (Est.)
VKTX
Viking Therapeu...
Healthcare 0.00% 0.07%
Sold All 😨
(Was: #64)
0.3 -366,083 -100.0%
CLOSED
$— 2018 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
AGIO
Agios Pharmaceu...
Healthcare 0.00% 0.06%
Sold All 😨
(Was: #66)
0.3 -189,866 -100.0%
CLOSED
$— 2013 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
HRTX
Heron Therapeut...
Healthcare 0.00% 0.04%
Sold All 😨
(Was: #72)
0.3 -4,251,951 -100.0%
CLOSED
$— 2014 Q1 13F Filing 2025-12-31 2026-02-14 (Est.)
MBX
MBX Biosciences...
Healthcare 0.00% 0.04%
Sold All 😨
(Was: #74)
0.3 -277,777 -100.0%
CLOSED
$— 2025 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
N/A
Generation Bio ...
Unknown 0.00% 0.01%
Sold All 😨
(Was: #84)
0.3 -194,493 -100.0%
CLOSED
$— 13F Filing 2025-12-31 2026-02-14 (Est.)
VYNE
VYNE Therapeuti...
Healthcare 0.00% 0.00%
Sold All 😨
(Was: #87)
0.3 -851,353 -100.0%
CLOSED
$— 2025 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
Showing 1-25 of 99 holdings

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