Stock Analysis
Data Source: SEC EDGAR 13F
Updated Hourly

Ionis Pharmaceuticals Inc (IONS)

504 + Investors. Track Smart Money conviction in IONS. See who's accumulating, reducing, or initiating positions.

Current Price
-- USD
Analyst Target
-- (0 analysts)
Upside
0.00%
Net Flow Q/Q
↑ +16
Streak
5Q ▲
Buyers last Q
56%

Smart Money Signals — IONS

Based on 512 hedge funds · latest filing: 2026 Q2 · updated quarterly

📈

Buying streak — 5 quarters in a row

last 6Q
For 5 consecutive quarters, more hedge funds added IONS than sold it. That's a consistent pattern of professional buying — not a one-time trade. When institutions keep buying quarter after quarter, it usually means they see a multi-year opportunity, not just a short-term momentum flip.
🏔️

At the ownership peak (100% of max)

100% of all-time peak
512 hedge funds hold IONS right now — the highest count in 3.0 years. When ownership is this concentrated, any bad news can trigger a chain reaction: one big fund sells, others follow. This is a classic 'crowded trade' — high popularity doesn't equal safety.
🚀

Fast accumulation — +40% more funds vs a year ago

fund count last 6Q
+145 new funds entered over the past year (+40% YoY). That's a rapid rush of institutional money. Fast accumulation often signals a major thesis — but it also means the stock could fall quickly if that thesis breaks.
🟡

Slight buying edge — 56% buying

280 buying217 selling
Last quarter: 280 funds bought or added vs 217 that reduced or exited. It's nearly a 50/50 split — some institutions are convinced, others are taking profits. This mixed picture is normal near price highs.
⚠️

Fewer new buyers each quarter (-7 vs last Q)

new funds entering per quarter
Funds opening this position for the first time: 116 → 113 → 74 → 67. Each quarter fewer new institutions are entering. This usually means most funds that wanted in are already in — the stock is well-known but the pool of potential new buyers is shrinking.
🔒

55% of holders stayed for 2+ years

■ 55% conviction (2yr+) ■ 25% medium ■ 21% new
280 out of 512 hedge funds have held IONS for over 2 years without selling. Long-term investors are generally harder to shake out during market stress, creating a stable ownership base that limits the risk of sudden capitulation.
📊

Peak discovery — momentum slowing

81 → 116 → 113 → 74 → 67 new funds/Q
New funds entering each quarter: 116 → 113 → 74 → 67. IONS is well-known in the hedge fund world, but fresh entries are gradually declining. The explosive phase of institutional discovery is likely behind us.
🏛️

Veteran-anchored — 65% veterans vs 25% newcomers

■ 65% veterans ■ 11% 1-2yr ■ 25% new
Entry-cohort mix of 544 holders: 351 (65%) are 2+ year veterans, 58 entered 1–2 years ago, and 135 (25%) joined within the past year. A veteran-weighted cap table skews toward institutional memory over fresh momentum.
🏆

Elite ownership — 66% AUM from top-100 funds

66% from top-100 AUM funds
66 of 505 holders are among the 100 largest funds by AUM, controlling 66% of total institutional value in IONS. When the biggest players dominate the cap table, it signifies deep institutional support — since mega-funds deploy the most rigorous due diligence and capital.
3.8
out of 10
Low Exit Risk
Exit risk score 3.8/10 — low institutional crowding. Ownership is below peak levels, holder base is relatively sticky, and buying momentum is positive.

Methodology note: these Smart Money cards use consecutive 13F disclosure snapshots, not trade-by-trade execution data. "Buying", "selling", "new holders", and "trimmed" refer to quarter-over-quarter changes in reported holders, aggregate shares, or disclosed position values between filings. They are useful for ownership regime analysis and crowding, but they do not imply exact trade timing on the filing date.

Institutional Sentiment Summary — IONS

In 2026 Q2, 280 hedge funds were net buyers of IONS (67 opened a new position, 213 added to an existing one), while 217 reduced or exited (166 trimmed, 51 sold completely) — a 56% buyer ratio, indicating a slight buying edge. This marks 5 consecutive quarters of net institutional buying — a persistent conviction signal. 66% of total institutional value in IONS is held by top-100 AUM funds, reflecting elite-tier ownership quality. Net fund flow last quarter: +16 funds (more new holders than closures). Total institutional holders: 512.

Hedge Fund Ownership: IONS

How many hedge funds hold IONS — quarterly history vs. share price
Quarterly hedge fund ownership of IONS vs. share price

Market Analysis: IONS

Analyst Price Targets

Avg. Price Target
--

Analyst Recommendations

Stock Performance

Real-time

Company Profile: IONS

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Institutional ownership data sourced from SEC EDGAR Form 13F-HR filings.

Loading signal freshness…
Smart Money Signal ?
Limited Smart Money Interest

No strong consensus or elite conviction detected among institutional holders.

16 top-rated funds 8 high-conviction
Consensus
5.3
/ 10
breadth
×
Elite
4.2
/ 10
conviction
Hedge Fund Positioning: IONS
504 + Investors

Track Smart Money conviction in IONS. See who's accumulating, reducing, or initiating positions.

Metric All 13F Filers (2026 Q2) Prior (2026 Q1) Change
Funds Holding 504 496 1.61%
13F Shares 187M 177M 5.23%
Total Value $13.98B $12.45B 12.31%
New Positions 67 74 -7
Increased Positions 203 185 +18
Closed Positions 52 72 -20
Reduced Positions 158 151 +7
Total Calls 24 17 41.18%
Total Puts 15 13 15.38%
PUT/CALL Ratio 0.62 0.76 Bullish

Statistics: IONS

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Institutional Holders (2026 Q2)

504 + investors

Explore institutional interest and hedge fund ownership dynamics. Analyze portfolio weights, new positions, and conviction trends in IONS. Verified SEC 13F-HR filings.

QUARTER:
Top 25 IONS holders by conviction (% of portfolio weight) — 2026 Q2 · Source: SEC Form 13F
# Investor % of Portfolio Shares Mkt Value
1 Tweedy, Browne Co LLC 13.70% 2,280,311 $180.8M
2 Davern Capital Partners, LP 10.80% 798,709 $63.3M
3 Boone Capital Management LLC 9.64% 519,977 $41.2M
4 Orion Investment Co 5.10% 220,335 $17.5M
5 Privium Fund Management B.V. 4.66% 319,924 $25.4M
6 Exome Asset Management LLC 4.31% 88,177 $7.0M
7 Ikarian Capital, LLC 3.42% 400,000 $31.7M
8 Sector Gamma As 3.26% 189,468 $15.0M
9 Sicart Associates LLC 3.12% 160,694 $12.7M
10 Atle Fund Management AB 2.93% 137,131 $10.9M
11 Eversept Partners, LP 2.73% 664,684 $52.7M
12 Ikarian Capital, LLC 2.56% 300,000 $23.8M
13 Eagle Health Investments LP 2.56% 194,577 $15.4M
14 Deep Track Capital, LP 2.54% 2,200,000 $174.4M
15 Artia Global Partners LP 2.11% 144,376 $11.4M
16 Deerfield Management Company, L.P. 1.64% 1,979,669 $157.0M
17 Future Fund LLC 1.62% 71,362 $5.7M
18 Bellevue Group AG 1.62% 972,258 $77.1M
19 Tetragon Partners GP Ltd 1.21% 97,173 $7.7M
20 Summit Partners Public Asset Management, LLC 1.10% 787,263 $62.4M
21 AlphaCentric Advisors LLC 1.04% 15,430 $1.2M
22 Groupama Asset Managment 0.95% 937,083 $75.2M
23 Integral Health Asset Management, LLC 0.94% 300,000 $23.8M
24 Baker BROS. Advisors LP 0.81% 2,047,727 $162.4M
25 West Michigan Advisors, LLC 0.74% 44,614 $3.4M
Investor Ownership
History 		% of Portfolio Prev % Rank Conviction Avg Buy Price 13F Score™ 3Y / 7Y Sell Timing Shares Mkt Value Change Change % Source Quarter Filed

Frequently Asked Questions — Ionis Pharmaceuticals Inc (IONS)

What does the Smart Money Trend signal show for IONS?

Buying streak — 5 quarters in a row: For 5 consecutive quarters, more hedge funds added IONS than sold it. That's a consistent pattern of professional buying — not a one-time trade. When institutions keep buying quarter after quarter, it usually means they see a multi-year opportunity, not just a short-term momentum flip.

What is the institutional breadth score for IONS?

Slight buying edge — 56% buying: Last quarter: 280 funds bought or added vs 217 that reduced or exited. It's nearly a 50/50 split — some institutions are convinced, others are taking profits. This mixed picture is normal near price highs.

What is the fund quality score for IONS holders?

Elite ownership — 66% AUM from top-100 funds: 66 of 505 holders are among the 100 largest funds by AUM, controlling 66% of total institutional value in IONS. When the biggest players dominate the cap table, it signifies deep institutional support — since mega-funds deploy the most rigorous due diligence and capital.

How long have hedge funds held IONS?

55% of holders stayed for 2+ years: 280 out of 512 hedge funds have held IONS for over 2 years without selling. Long-term investors are generally harder to shake out during market stress, creating a stable ownership base that limits the risk of sudden capitulation.

Where does this institutional ownership data come from?

All holdings data is sourced from SEC Form 13F filings, which institutional investment managers with over $100 million in assets are required to submit quarterly. Data is parsed directly from SEC EDGAR.

Disclaimer: The information on this page is for informational purposes only and does not constitute investment advice, a recommendation, or an offer to buy or sell any security. Institutional holdings data is sourced from SEC Form 13F filings and reflects positions as of the filing date. Past performance of any fund or portfolio is not indicative of future results. 13Foresight is not a registered investment adviser. Always conduct your own due diligence before making investment decisions.

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