Stock Analysis
Data Source: SEC EDGAR 13F
Updated Hourly

Denali Therapeutics Inc (DNLI)

286 + Investors. Track Smart Money conviction in DNLI. See who's accumulating, reducing, or initiating positions.

Current Price
-- USD
Analyst Target
-- (0 analysts)
Upside
0.00%
Net Flow Q/Q
↑ +21
Streak
5Q ▲
Buyers last Q
63%

Smart Money Signals — DNLI

Based on 290 hedge funds · latest filing: 2026 Q2 · updated quarterly

📈

Buying streak — 5 quarters in a row

last 6Q
For 5 consecutive quarters, more hedge funds added DNLI than sold it. That's a consistent pattern of professional buying — not a one-time trade. When institutions keep buying quarter after quarter, it usually means they see a multi-year opportunity, not just a short-term momentum flip.
🏔️

At the ownership peak (100% of max)

100% of all-time peak
290 hedge funds hold DNLI right now — the highest count in 3.0 years. When ownership is this concentrated, any bad news can trigger a chain reaction: one big fund sells, others follow. This is a classic 'crowded trade' — high popularity doesn't equal safety.
🚀

Fast accumulation — +27% more funds vs a year ago

fund count last 6Q
+62 new funds entered over the past year (+27% YoY). That's a rapid rush of institutional money. Fast accumulation often signals a major thesis — but it also means the stock could fall quickly if that thesis breaks.
🟢

More buyers than sellers — 63% buying

178 buying104 selling
Last quarter: 178 funds were net buyers (55 opened a brand new position + 123 added to an existing one). Only 104 were sellers (70 trimmed + 34 sold completely). A clear majority buying is a strong confirmation signal.
➡️

Steady new buyers — ~55 new funds per quarter

new funds entering per quarter
Funds opening this position for the first time: 33 → 52 → 56 → 55. A stable flow of new institutional buyers suggests ongoing interest without signs of either acceleration or slowdown.
🔒

49% of holders stayed for 2+ years

■ 49% conviction (2yr+) ■ 23% medium ■ 28% new
142 out of 290 hedge funds have held DNLI for over 2 years without selling. Long-term investors are generally harder to shake out during market stress, creating a stable ownership base that limits the risk of sudden capitulation.
💰

Value +36% but shares only +6% — price-driven

Value
+36%
Shares
+5%
Last quarter: the total dollar value of institutional holdings rose +36%, but actual share count only changed +6%. The gap is explained by the stock's price rising — not new buying. Strong value growth with weak share growth means the rally is price momentum, not fresh institutional demand.
📈

Growing discovery — still being found

48 → 33 → 52 → 56 → 55 new funds/Q
New funds entering each quarter: 33 → 52 → 56 → 55. A growing number of institutions are discovering DNLI each quarter. The narrative is still spreading — leaving room for ongoing capital accumulation.
🏛️

Veteran-anchored — 55% veterans vs 32% newcomers

■ 55% veterans ■ 13% 1-2yr ■ 32% new
Entry-cohort mix of 295 holders: 163 (55%) are 2+ year veterans, 38 entered 1–2 years ago, and 94 (32%) joined within the past year. A veteran-weighted cap table skews toward institutional memory over fresh momentum.
🏆

Elite ownership — 51% AUM from top-100 funds

51% from top-100 AUM funds
52 of 287 holders are among the 100 largest funds by AUM, controlling 51% of total institutional value in DNLI. When the biggest players dominate the cap table, it signifies deep institutional support — since mega-funds deploy the most rigorous due diligence and capital.
4.1
out of 10
Moderate Exit Risk
Exit risk score 4.1/10 — some crowding factors present, but no critical concentration. Watch ownership trend over the next 1–2 quarters for direction.

Methodology note: these Smart Money cards use consecutive 13F disclosure snapshots, not trade-by-trade execution data. "Buying", "selling", "new holders", and "trimmed" refer to quarter-over-quarter changes in reported holders, aggregate shares, or disclosed position values between filings. They are useful for ownership regime analysis and crowding, but they do not imply exact trade timing on the filing date.

Institutional Sentiment Summary — DNLI

In 2026 Q2, 178 hedge funds were net buyers of DNLI (55 opened a new position, 123 added to an existing one), while 104 reduced or exited (70 trimmed, 34 sold completely) — a 63% buyer ratio, indicating clear institutional accumulation. This marks 5 consecutive quarters of net institutional buying — a persistent conviction signal. 51% of total institutional value in DNLI is held by top-100 AUM funds, reflecting elite-tier ownership quality. Net fund flow last quarter: +21 funds (more new holders than closures). Total institutional holders: 290.

Hedge Fund Ownership: DNLI

How many hedge funds hold DNLI — quarterly history vs. share price
Quarterly hedge fund ownership of DNLI vs. share price

Market Analysis: DNLI

Analyst Price Targets

Avg. Price Target
--

Analyst Recommendations

Stock Performance

Real-time

Company Profile: DNLI

-- --

Institutional ownership data sourced from SEC EDGAR Form 13F-HR filings.

Is It Too Late to Buy Denali Therapeutics Inc (DNLI) Based on Hedge Fund 13F Filings?

Signal Freshness measures how much DNLI has moved relative to its sector benchmark (XLV) since the 2026 Q2 13F filing. A stock that has barely outrun its sector is still a relatively fresh entry point — the fund's thesis has not yet been priced in by the broader market.

Since Quarter End June 30, 2026 · 91d ago
DNLI
-18.4%
XLV
+8.4%

DNLI outperformed XLV by -26.8% since June 30, 2026.

Since 13F Filing Date August 14, 2026 · 46d ago
DNLI
-14.0%
XLV
+2.7%

Since the filing became public, DNLI outperformed XLV by -16.7% .

Interpretation: The stock is tracking its sector benchmark closely. The signal remains fresh and the entry point is still near the fund's implied reference. Learn more →

Smart Money Signal ?
Limited Smart Money Interest

No strong consensus or elite conviction detected among institutional holders.

11 top-rated funds 3 high-conviction
Consensus
4.7
/ 10
breadth
×
Elite
3.2
/ 10
conviction
Hedge Fund Positioning: DNLI
286 + Investors

Track Smart Money conviction in DNLI. See who's accumulating, reducing, or initiating positions.

Metric All 13F Filers (2026 Q2) Prior (2026 Q1) Change
Funds Holding 286 269 6.32%
13F Shares 159M 151M 5.53%
Total Value $3.62B $2.65B 36.47%
New Positions 55 56 -1
Increased Positions 121 104 +17
Closed Positions 35 34 +1
Reduced Positions 68 57 +11
Total Calls 4 9 -55.56%
Total Puts 4 6 -33.33%
PUT/CALL Ratio 1.0 0.67 Neutral

Statistics: DNLI

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Valuation Measures Data as of: --

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Enterprise Value/EBITDA --
Beta (5Y Monthly) --
Short Ratio (Days to Cover) --
Short % of Float --

Financial Highlights

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Institutional Holders (2026 Q2)

286 + investors

Explore institutional interest and hedge fund ownership dynamics. Analyze portfolio weights, new positions, and conviction trends in DNLI. Verified SEC 13F-HR filings.

QUARTER:
Top 25 DNLI holders by conviction (% of portfolio weight) — 2026 Q2 · Source: SEC Form 13F
# Investor % of Portfolio Shares Mkt Value
1 Foresite Capital Management VI LLC 5.59% 1,396,771 $35.9M
2 DAFNA Capital Management LLC 3.62% 739,014 $19.0M
3 Casdin Capital, LLC 2.63% 2,045,000 $52.6M
4 Cercano Management LLC 1.55% 625,000 $16.1M
5 Defilade Capital Management, L.P. 1.35% 391,866 $10.1M
6 ADAR1 Capital Management, LLC 1.21% 1,029,080 $26.5M
7 Privium Fund Management B.V. 1.09% 229,857 $5.9M
8 Lumbard & Kellner, LLC 0.77% 98,282 $2.5M
9 Siren, L.L.C. 0.73% 1,396,513 $35.9M
10 Odyssean, LLC 0.52% 125,062 $3.2M
11 Yorktown Management & Research Co Inc 0.51% 32,100 $826K
12 1492 Capital Management LLC 0.50% 66,368 $1.7M
13 Temasek Holdings (Private) Ltd 0.48% 7,012,974 $180.4M
14 Baker BROS. Advisors LP 0.48% 3,734,336 $96.0M
15 Ironwood Investment Management LLC 0.46% 52,080 $1.3M
16 Rhenman & Partners Asset Management AB 0.43% 179,000 $4.6M
17 Virtus Investment Advisers, LLC 0.32% 53,688 $1.4M
18 Baillie Gifford & Co 0.28% 11,960,230 $307.6M
19 Bayforest Capital Ltd 0.27% 11,437 $294K
20 Phocas Financial Corp. 0.25% 71,197 $1.8M
21 Holocene Advisors, LP 0.23% 3,905,225 $100.4M
22 PFM Health Sciences, LP 0.22% 100,966 $2.6M
23 Burkehill Global Management, LP 0.19% 200,000 $5.1M
24 Segall Bryant & Hamill, LLC 0.16% 519,483 $13.4M
25 Candriam S.C.A. 0.14% 1,189,886 $30.6M
Investor Ownership
History 		% of Portfolio Prev % Rank Conviction Avg Buy Price 13F Score™ 3Y / 7Y Sell Timing Shares Mkt Value Change Change % Source Quarter Filed

Frequently Asked Questions — Denali Therapeutics Inc (DNLI)

What does the Smart Money Trend signal show for DNLI?

Buying streak — 5 quarters in a row: For 5 consecutive quarters, more hedge funds added DNLI than sold it. That's a consistent pattern of professional buying — not a one-time trade. When institutions keep buying quarter after quarter, it usually means they see a multi-year opportunity, not just a short-term momentum flip.

What is the institutional breadth score for DNLI?

More buyers than sellers — 63% buying: Last quarter: 178 funds were net buyers (55 opened a brand new position + 123 added to an existing one). Only 104 were sellers (70 trimmed + 34 sold completely). A clear majority buying is a strong confirmation signal.

What is the fund quality score for DNLI holders?

Elite ownership — 51% AUM from top-100 funds: 52 of 287 holders are among the 100 largest funds by AUM, controlling 51% of total institutional value in DNLI. When the biggest players dominate the cap table, it signifies deep institutional support — since mega-funds deploy the most rigorous due diligence and capital.

How long have hedge funds held DNLI?

49% of holders stayed for 2+ years: 142 out of 290 hedge funds have held DNLI for over 2 years without selling. Long-term investors are generally harder to shake out during market stress, creating a stable ownership base that limits the risk of sudden capitulation.

Is it too late to buy Denali Therapeutics Inc (DNLI) following the 2026 Q2 hedge fund 13F filings?

As of today, DNLI has moved -14.0% since the 2026 Q2 13F filing date (August 14, 2026), compared to +2.7% for the XLV sector ETF — an outperformance of -16.7%. Since the quarter end (June 30, 2026), DNLI has gained -18.4% vs +8.4% for XLV. The stock is tracking its sector benchmark closely. The signal remains fresh and the entry point is still near the fund's implied reference.

Where does this institutional ownership data come from?

All holdings data is sourced from SEC Form 13F filings, which institutional investment managers with over $100 million in assets are required to submit quarterly. Data is parsed directly from SEC EDGAR.

Disclaimer: The information on this page is for informational purposes only and does not constitute investment advice, a recommendation, or an offer to buy or sell any security. Institutional holdings data is sourced from SEC Form 13F filings and reflects positions as of the filing date. Past performance of any fund or portfolio is not indicative of future results. 13Foresight is not a registered investment adviser. Always conduct your own due diligence before making investment decisions.

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