2026 Q3 Portfolio Activity
In 2026 Q3, Siren, L.L.C. maintained a portfolio of 134 distinct positions. The most significant new addition was ADARx Pharmaceuticals, Inc., now representing 0.91% of the total fund value. They heavily accumulated shares in Tyra Biosciences, Inc., increasing the position by 368.4%. Conversely, Siren, L.L.C. completely exited their position in Definium Therapeutics Inc.
Position History
hover any row below to update
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Total Positions
134
Quarter
2026 Q3
Top Holding
SRRK (10.7%)
Top 10 Concentration
47.2%
Turnover Rate
23.4%
Sector HHI
0.18
Items per page:
Showing 1-50 of 134
Siren, L.L.C. Full Holdings List — 2026 Q3
| Stock | History | Sector / Type | Port % | Prev % | Rank / Prev | Conviction | Change | % Change | Influence | Shares | Mkt Value | Avg Cost | Price Held | 1st Owned | Source | Source Date | Date Reported | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
SRRK
Scholar Rock Ho...
|
Healthcare | 10.71% | 10.66% |
#1
Prev: #1
|
6.5 |
—
|
-200,000 | -2.1% |
P
S
|
9,375,013 | $453,000,628 |
$12.43
+247.5%
|
2024 Q3 | 13F Filing | 2026-09-30 | 2026-11-12 | ||
|
KYMR
Kymera Therapeu...
|
Healthcare | 7.36% | 6.81% |
#2
Prev: #2
|
4.9 |
—
|
-150,932 | -5.1% |
P
S
|
2,784,898 | $311,323,747 |
$45.55
+180.1%
|
2024 Q3 | 13F Filing | 2026-09-30 | 2026-11-12 | ||
|
ERAS
Erasca, Inc.
|
Healthcare | 4.57% | 4.23% |
#3
Prev: #3
|
4.8 |
—
|
1,800,000 | 15.8% |
P
S
|
13,197,781 | $193,479,469 |
$7.04
+122.4%
|
2024 Q3 | 13F Filing | 2026-09-30 | 2026-11-12 | ||
|
RVMD
Revolution Medi...
|
Healthcare | 4.12% | 3.41% |
#4
2
Prev: #6
|
2.6 |
—
|
-50,000 | -5.6% |
P
S
|
850,000 | $174,471,000 | 2024 Q3 | 13F Filing | 2026-09-30 | 2026-11-12 | |||
|
ONC
BeOne Medicines...
|
Healthcare | 4.02% | 2.68% |
#5
4
Prev: #9
|
3.1 |
—
|
no change | no change |
P
S
|
465,000 | $170,162,100 | 2024 Q3 | 13F Filing | 2026-09-30 | 2026-11-12 | |||
|
TNGX
Tango Therapeut...
|
Healthcare | 4.00% | 3.91% |
#6
1
Prev: #5
|
3.6 |
—
|
604,717 | 9.8% |
P
S
|
6,784,081 | $169,262,821 | 2024 Q3 | 13F Filing | 2026-09-30 | 2026-11-12 | |||
|
MANE
Veradermics, In...
|
Healthcare | 3.79% | 4.12% |
#7
3
Prev: #4
|
1.5 |
—
|
-331,075 | -20.0% |
P
S
|
1,324,299 | $160,544,768 | 2026 Q1 | 13F Filing | 2026-09-30 | 2026-11-12 | |||
|
ARWR
Arrowhead Pharm...
|
Healthcare | 3.54% | 2.83% |
#8
Prev: #8
|
3.9 |
—
|
575,000 | 33.5% |
P
S
|
2,290,476 | $149,911,654 | 2024 Q3 | 13F Filing | 2026-09-30 | 2026-11-12 | |||
|
EWTX
Edgewise Therap...
|
Healthcare | 2.69% | 2.62% |
#9
1
Prev: #10
|
1.6 |
—
|
-380,450 | -11.9% |
P
S
|
2,804,179 | $113,849,667 | 2024 Q3 | 13F Filing | 2026-09-30 | 2026-11-12 | |||
|
RYTM
Rhythm Pharmace...
|
Healthcare | 2.44% | 2.55% |
#10
1
Prev: #11
|
1.5 |
—
|
-50,000 | -4.4% |
P
S
|
1,086,275 | $103,429,674 | 2025 Q1 | 13F Filing | 2026-09-30 | 2026-11-12 | |||
|
BCAX
Bicara Therapeu...
|
Healthcare | 2.42% | 3.37% |
#11
4
Prev: #7
|
1.5 |
—
|
-100,000 | -1.8% |
P
S
|
5,502,970 | $102,410,272 | 2024 Q3 | 13F Filing | 2026-09-30 | 2026-11-12 | |||
|
PBLS
Parabilis Medic...
|
Healthcare | 2.28% | 1.66% |
#12
3
Prev: #15
|
1.9 |
—
|
no change | no change |
P
S
|
2,992,259 | $96,620,043 | 2026 Q2 | 13F Filing | 2026-09-30 | 2026-11-12 | |||
|
LXRX
Lexicon Pharmac...
|
Healthcare | 1.97% | 2.15% |
#13
1
Prev: #12
|
1.8 |
—
|
no change | no change |
P
S
|
44,303,518 | $83,290,614 | 2024 Q3 | 13F Filing | 2026-09-30 | 2026-11-12 | |||
|
SYRE
Spyre Therapeut...
|
Healthcare | 1.83% | 1.74% |
#14
Prev: #14
|
1.2 |
—
|
-100,000 | -10.3% |
P
S
|
868,598 | $77,331,280 | 2024 Q4 | 13F Filing | 2026-09-30 | 2026-11-12 | |||
|
TYRA
Tyra Bioscience...
|
Healthcare | 1.76% | 0.47% |
#15
39
Prev: #54
|
3.7 |
—
|
2,670,887 | 368.4% |
P
S
|
3,395,887 | $74,268,049 | 2026 Q2 | 13F Filing | 2026-09-30 | 2026-11-12 | |||
|
COAG
Hemab Therapeut...
|
Healthcare | 1.72% | 1.55% |
#16
3
Prev: #19
|
2.7 |
—
|
279,401 | 13.4% |
P
S
|
2,366,235 | $72,974,687 | 2026 Q2 | 13F Filing | 2026-09-30 | 2026-11-12 | |||
|
AMLX
Amylyx Pharmace...
|
Healthcare | 1.71% | 0.54% |
#17
31
Prev: #48
|
3.7 |
—
|
1,000,000 | 67.5% |
P
S
|
2,480,586 | $72,185,053 | 2026 Q1 | 13F Filing | 2026-09-30 | 2026-11-12 | |||
|
ELVN
Enliven Therape...
|
Healthcare | 1.60% | 1.82% |
#18
5
Prev: #13
|
1.1 |
—
|
-299,248 | -16.9% |
P
S
|
1,475,163 | $67,621,472 | 2026 Q1 | 13F Filing | 2026-09-30 | 2026-11-12 | |||
|
SEPN
Septerna, Inc.
|
Healthcare | 1.57% | 1.29% |
#19
9
Prev: #28
|
1.1 |
—
|
-200,000 | -10.5% |
P
S
|
1,700,000 | $66,521,000 | 2024 Q4 | 13F Filing | 2026-09-30 | 2026-11-12 | |||
|
RCUS
Arcus Bioscienc...
|
Healthcare | 1.48% | 1.51% |
#20
Prev: #20
|
1.6 |
—
|
no change | no change |
P
S
|
2,420,430 | $62,519,707 | 2024 Q3 | 13F Filing | 2026-09-30 | 2026-11-12 | |||
|
RLAY
Relay Therapeut...
|
Healthcare | 1.39% | 1.38% |
#21
1
Prev: #22
|
1.1 |
—
|
-387,024 | -10.6% |
P
S
|
3,262,976 | $58,896,717 | 2026 Q2 | 13F Filing | 2026-09-30 | 2026-11-12 | |||
|
IRON
Disc Medicine, ...
|
Healthcare | 1.37% | 1.31% |
#22
4
Prev: #26
|
1.5 |
—
|
no change | no change |
P
S
|
888,401 | $58,154,729 | 2025 Q1 | 13F Filing | 2026-09-30 | 2026-11-12 | |||
|
SLDB
Solid Bioscienc...
|
Healthcare | 1.31% | 1.55% |
#23
6
Prev: #17
|
1.5 |
—
|
no change | no change |
P
S
|
7,690,405 | $55,601,628 | 2024 Q3 | 13F Filing | 2026-09-30 | 2026-11-12 | |||
|
STOK
Stoke Therapeut...
|
Healthcare | 1.23% | 1.32% |
#24
1
Prev: #25
|
1.5 |
—
|
no change | no change |
P
S
|
1,995,347 | $51,879,022 | 2024 Q4 | 13F Filing | 2026-09-30 | 2026-11-12 | |||
|
COGT
Cogent Bioscien...
|
Healthcare | 1.22% | 1.46% |
#25
4
Prev: #21
|
1.0 |
—
|
-250,000 | -13.4% |
P
S
|
1,609,279 | $51,529,114 | 2025 Q2 | 13F Filing | 2026-09-30 | 2026-11-12 | |||
|
TSHA
Taysha Gene The...
|
Healthcare | 1.13% | 1.36% |
#26
3
Prev: #23
|
1.5 |
—
|
no change | no change |
P
S
|
9,846,579 | $47,952,840 | 2024 Q3 | 13F Filing | 2026-09-30 | 2026-11-12 | |||
|
CYTK
Cytokinetics, I...
|
Healthcare | 1.10% | 1.31% |
#27
Prev: #27
|
0.9 |
—
|
-50,000 | -6.6% |
P
S
|
708,952 | $46,727,026 | 2024 Q3 | 13F Filing | 2026-09-30 | 2026-11-12 | |||
|
ORIC
ORIC Pharmaceut...
|
Healthcare | 1.07% | 0.66% |
#28
14
Prev: #42
|
2.4 |
—
|
360,000 | 12.0% |
P
S
|
3,358,192 | $45,234,846 | 2024 Q3 | 13F Filing | 2026-09-30 | 2026-11-12 | |||
|
OLMA
Olema Pharmaceu...
|
Healthcare | 0.99% | 1.23% |
#29
Prev: #29
|
1.4 |
—
|
no change | no change |
P
S
|
4,856,949 | $41,964,039 | 2025 Q4 | 13F Filing | 2026-09-30 | 2026-11-12 | |||
|
DYN
Dyne Therapeuti...
|
Healthcare | 0.92% | 0.96% |
#30
2
Prev: #32
|
2.4 |
—
|
300,000 | 14.1% |
P
S
|
2,429,125 | $39,133,204 | 2024 Q3 | 13F Filing | 2026-09-30 | 2026-11-12 | |||
|
ADRX
ADARx Pharmaceu...
|
Healthcare | 0.91% | — |
#31
Prev: #—
|
3.9 |
—
|
1,925,794 | — |
NEW
|
1,925,794 | $38,400,332 | 2026 Q3 | 13F Filing | 2026-09-30 | 2026-11-12 | |||
|
RELY
Remitly Global ...
|
Technology | 0.78% | 0.70% |
#32
6
Prev: #38
|
1.3 |
—
|
no change | no change |
P
S
|
1,543,271 | $32,933,403 | 2024 Q3 | 13F Filing | 2026-09-30 | 2026-11-12 | |||
|
SLN
Silence Therape...
|
Healthcare | 0.75% | 0.74% |
#33
3
Prev: #36
|
0.8 |
—
|
-423,571 | -12.8% |
P
S
|
2,887,867 | $31,564,386 | 2024 Q3 | 13F Filing | 2026-09-30 | 2026-11-12 | |||
|
ASND
Ascendis Pharma...
|
Healthcare | 0.70% | — |
#34
Prev: #—
|
3.8 |
—
|
130,000 | — |
NEW
|
130,000 | $29,617,900 | 2024 Q3 | 13F Filing | 2026-09-30 | 2026-11-12 | |||
|
DNLI
Denali Therapeu...
|
Healthcare | 0.68% | 0.73% |
#35
2
Prev: #37
|
1.3 |
—
|
no change | no change |
P
S
|
1,396,513 | $28,865,924 | 2024 Q3 | 13F Filing | 2026-09-30 | 2026-11-12 | |||
|
PVLA
Palvella Therap...
|
Healthcare | 0.68% | 0.80% |
#36
1
Prev: #35
|
0.8 |
—
|
-50,000 | -19.4% |
P
S
|
207,485 | $28,618,406 | 2025 Q4 | 13F Filing | 2026-09-30 | 2026-11-12 | |||
|
DBVT
Dbv Technologie...
|
Healthcare | 0.65% | 0.62% |
#37
7
Prev: #44
|
2.8 |
—
|
499,177 | 26.9% |
P
S
|
2,356,539 | $27,712,899 | 2025 Q4 | 13F Filing | 2026-09-30 | 2026-11-12 | |||
|
CGEM
Cullinan Therap...
|
Healthcare | 0.65% | 0.70% |
#38
1
Prev: #39
|
0.8 |
—
|
-100,000 | -5.3% |
P
S
|
1,793,410 | $27,528,844 | 2024 Q3 | 13F Filing | 2026-09-30 | 2026-11-12 | |||
|
GOOGL
Alphabet Inc.
|
Communication Services | 0.65% | 0.65% |
#39
4
Prev: #43
|
0.8 |
—
|
-10,000 | -11.1% |
P
S
|
80,000 | $27,526,400 | 2024 Q3 | 13F Filing | 2026-09-30 | 2026-11-12 | |||
|
GPCR
Structure Thera...
|
Healthcare | 0.65% | 0.95% |
#40
7
Prev: #33
|
1.3 |
—
|
no change | no change |
P
S
|
872,967 | $27,297,678 | 2025 Q3 | 13F Filing | 2026-09-30 | 2026-11-12 | |||
|
XENE
Xenon Pharmaceu...
|
Healthcare | 0.63% | 1.61% |
#41
25
Prev: #16
|
0.3 |
—
|
-600,258 | -45.5% |
P
S
|
718,306 | $26,713,800 | 2024 Q3 | 13F Filing | 2026-09-30 | 2026-11-12 | |||
|
KLRA
Kailera Therape...
|
Healthcare | 0.60% | 0.99% |
#42
11
Prev: #31
|
1.2 |
—
|
no change | no change |
P
S
|
2,214,286 | $25,287,146 | 2026 Q2 | 13F Filing | 2026-09-30 | 2026-11-12 | |||
|
AGEN
Agenus Inc
|
Healthcare | 0.57% | 0.07% |
#43
57
Prev: #100
|
3.2 |
—
|
1,355,013 | 127.3% |
P
S
|
2,419,263 | $24,023,282 | 2024 Q3 | 13F Filing | 2026-09-30 | 2026-11-12 | |||
|
NVDA
NVIDIA Corporat...
|
Technology | 0.53% | 0.38% |
#44
13
Prev: #57
|
0.7 |
—
|
2,500 | 2.6% |
P
S
|
97,500 | $22,267,050 | 2024 Q3 | 13F Filing | 2026-09-30 | 2026-11-12 | |||
|
SPTX
Seaport Therape...
|
Healthcare | 0.52% | 0.48% |
#45
7
Prev: #52
|
1.2 |
—
|
no change | no change |
P
S
|
1,095,316 | $22,092,524 | 2026 Q2 | 13F Filing | 2026-09-30 | 2026-11-12 | |||
|
TRVI
Trevi Therapeut...
|
Healthcare | 0.52% | 0.67% |
#46
5
Prev: #41
|
0.7 |
—
|
-262,978 | -14.7% |
P
S
|
1,523,889 | $21,822,090 | 2024 Q4 | 13F Filing | 2026-09-30 | 2026-11-12 | |||
|
RAPP
Rapport Therape...
|
Healthcare | 0.51% | 0.54% |
#47
Prev: #47
|
1.2 |
—
|
no change | no change |
P
S
|
641,469 | $21,553,358 | 2024 Q3 | 13F Filing | 2026-09-30 | 2026-11-12 | |||
|
MNPR
Monopar Therape...
|
Healthcare | 0.51% | 0.51% |
#48
2
Prev: #50
|
1.2 |
—
|
no change | no change |
P
S
|
270,118 | $21,520,301 | 2025 Q4 | 13F Filing | 2026-09-30 | 2026-11-12 | |||
|
TSM
Taiwan Semicond...
|
Technology | 0.49% | 0.43% |
#49
7
Prev: #56
|
0.7 |
—
|
300 | 0.7% |
P
S
|
45,000 | $20,528,550 | 2024 Q3 | 13F Filing | 2026-09-30 | 2026-11-12 | |||
|
N/A
Damora Therapeu...
|
|
Unknown | 0.45% | — |
#50
Prev: #—
|
3.7 |
—
|
900,000 | — |
NEW
|
900,000 | $19,152,000 | — | 13F Filing | 2026-09-30 | 2026-11-12 |
Showing 1-50 of 134 holdings