2026 Q2 Portfolio Activity
In 2026 Q2, Siren, L.L.C. maintained a portfolio of 127 distinct positions. The most significant new addition was Abivax SA, now representing 1.55% of the total fund value. They heavily accumulated shares in Veradermics Inc, increasing the position by 1555.4%. The fund also reduced its exposure to Veradermics Inc by 98.7%.
Position History
hover any row below to update
Loading…
Total Positions
127
Quarter
2026 Q2
Top Holding
SRRK (10.7%)
Top 10 Concentration
44.6%
Turnover Rate
23.4%
Sector HHI
0.18
Items per page:
Showing 1-50 of 127
Siren, L.L.C. Full Holdings List — 2026 Q2
| Stock | History | Sector / Type | Port % | Prev % | Rank / Prev | Conviction | Change | % Change | Influence | Shares | Mkt Value | Avg Cost | Price Held | 1st Owned | Source | Source Date | Date Reported | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
SRRK
Scholar Rock Ho...
|
Healthcare | 10.66% | 14.75% |
#1
Prev: #1
|
6.5 |
—
|
-1,250,000 | -11.5% |
P
S
|
9,575,013 | $526,625,715 |
$12.43
+326.8%
|
2024 Q3 | 13F Filing | 2026-06-30 | 2026-08-13 | ||
|
KYMR
Kymera Therapeu...
|
Healthcare | 6.81% | 7.36% |
#2
Prev: #2
|
4.7 |
—
|
-251,000 | -7.9% |
P
S
|
2,935,830 | $336,651,626 | 2024 Q3 | 13F Filing | 2026-06-30 | 2026-08-13 | |||
|
ERAS
Erasca Inc
|
Healthcare | 4.23% | 5.04% |
#3
Prev: #3
|
3.2 |
—
|
153,535 | 1.4% |
P
S
|
11,397,781 | $208,807,348 | 2024 Q3 | 13F Filing | 2026-06-30 | 2026-08-13 | |||
|
N/A
Veradermics Inc
|
|
Unknown | 4.12% | 2.64% |
#4
6
Prev: #10
|
4.1 |
—
|
150,000 | 10.0% |
P
S
|
1,655,374 | $203,511,680 | — | 13F Filing | 2026-06-30 | 2026-08-13 | ||
|
TNGX
Tango Therapeut...
|
Healthcare | 3.91% | 3.28% |
#5
1
Prev: #6
|
4.1 |
—
|
522,259 | 9.2% |
P
S
|
6,179,364 | $193,166,919 | 2024 Q3 | 13F Filing | 2026-06-30 | 2026-08-13 | |||
|
RVMD
Revolution Medi...
|
Healthcare | 3.41% | 3.00% |
#6
2
Prev: #8
|
1.9 |
—
|
-210,980 | -19.0% |
P
S
|
900,000 | $168,552,000 | 2024 Q3 | 13F Filing | 2026-06-30 | 2026-08-13 | |||
|
BCAX
Bicara Therapeu...
|
Healthcare | 3.37% | 3.20% |
#7
Prev: #7
|
1.8 |
—
|
-200,000 | -3.4% |
P
S
|
5,602,970 | $166,352,179 | 2024 Q3 | 13F Filing | 2026-06-30 | 2026-08-13 | |||
|
ARWR
Arrowhead Pharm...
|
Healthcare | 2.83% | 2.81% |
#8
1
Prev: #9
|
3.1 |
—
|
100,000 | 6.2% |
P
S
|
1,715,476 | $139,828,449 | 2024 Q3 | 13F Filing | 2026-06-30 | 2026-08-13 | |||
|
ONC
BeOne Medicines...
|
Healthcare | 2.68% | 3.83% |
#9
4
Prev: #5
|
2.1 |
—
|
no change | no change |
P
S
|
465,000 | $132,511,050 | 2024 Q3 | 13F Filing | 2026-06-30 | 2026-08-13 | |||
|
EWTX
Edgewise Therap...
|
Healthcare | 2.62% | 3.87% |
#10
6
Prev: #4
|
1.0 |
—
|
-1,245,634 | -28.1% |
P
S
|
3,184,629 | $129,391,476 | 2024 Q3 | 13F Filing | 2026-06-30 | 2026-08-13 | |||
|
RYTM
Rhythm Pharmace...
|
Healthcare | 2.55% | 1.75% |
#11
9
Prev: #20
|
4.0 |
—
|
410,764 | 56.6% |
P
S
|
1,136,275 | $126,160,613 | 2025 Q1 | 13F Filing | 2026-06-30 | 2026-08-13 | |||
|
LXRX
Lexicon Pharmac...
|
Healthcare | 2.15% | 1.92% |
#12
2
Prev: #14
|
1.9 |
—
|
no change | no change |
P
S
|
44,303,518 | $106,328,443 | 2024 Q3 | 13F Filing | 2026-06-30 | 2026-08-13 | |||
|
ELVN
Enliven Therape...
|
Healthcare | 1.82% | 0.81% |
#13
20
Prev: #33
|
3.7 |
—
|
1,028,185 | 137.8% |
P
S
|
1,774,411 | $90,051,358 | 2026 Q1 | 13F Filing | 2026-06-30 | 2026-08-13 | |||
|
SYRE
Spyre Therapeut...
|
Healthcare | 1.74% | 1.14% |
#14
10
Prev: #24
|
2.7 |
—
|
150,000 | 18.3% |
P
S
|
968,598 | $85,992,130 | 2024 Q4 | 13F Filing | 2026-06-30 | 2026-08-13 | |||
|
N/A
Parabilis Medic...
|
|
Unknown | 1.66% | — |
#15
Prev: #—
|
4.2 |
—
|
2,992,259 | — |
NEW
|
2,992,259 | $81,898,129 | — | 13F Filing | 2026-06-30 | 2026-08-13 | ||
|
XENE
Xenon Pharmaceu...
|
Healthcare | 1.61% | 2.13% |
#16
5
Prev: #11
|
1.6 |
—
|
no change | no change |
P
S
|
1,318,564 | $79,588,523 | 2024 Q3 | 13F Filing | 2026-06-30 | 2026-08-13 | |||
|
SLDB
Solid Bioscienc...
|
Healthcare | 1.55% | 1.53% |
#17
4
Prev: #21
|
1.6 |
—
|
no change | no change |
P
S
|
7,690,405 | $76,827,146 | 2024 Q3 | 13F Filing | 2026-06-30 | 2026-08-13 | |||
|
ABVX
Abivax SA
|
Healthcare | 1.55% | — |
#18
Prev: #—
|
4.1 |
—
|
576,000 | — |
NEW
|
576,000 | $76,757,760 | 2026 Q2 | 13F Filing | 2026-06-30 | 2026-08-13 | |||
|
N/A
Hemab Therapeut...
|
|
Unknown | 1.55% | — |
#19
Prev: #—
|
4.1 |
—
|
2,086,834 | — |
NEW
|
2,086,834 | $76,649,413 | — | 13F Filing | 2026-06-30 | 2026-08-13 | ||
|
RCUS
Arcus Bioscienc...
|
Healthcare | 1.51% | 1.80% |
#20
3
Prev: #17
|
1.1 |
—
|
-586,647 | -19.5% |
P
S
|
2,420,430 | $74,621,857 | 2024 Q3 | 13F Filing | 2026-06-30 | 2026-08-13 | |||
|
COGT
Cogent Bioscien...
|
Healthcare | 1.46% | 1.82% |
#21
6
Prev: #15
|
2.6 |
—
|
150,000 | 8.8% |
P
S
|
1,859,279 | $71,954,097 | 2025 Q2 | 13F Filing | 2026-06-30 | 2026-08-13 | |||
|
RLAY
Relay Therapeut...
|
Healthcare | 1.38% | — |
#22
Prev: #—
|
4.1 |
—
|
3,650,000 | — |
NEW
|
3,650,000 | $68,291,500 | 2026 Q2 | 13F Filing | 2026-06-30 | 2026-08-13 | |||
|
TSHA
Taysha Gene The...
|
Healthcare | 1.36% | 1.09% |
#23
4
Prev: #27
|
2.5 |
—
|
1,016,666 | 11.5% |
P
S
|
9,846,579 | $67,055,203 | 2024 Q3 | 13F Filing | 2026-06-30 | 2026-08-13 | |||
|
DFTX
Definium Therap...
|
Healthcare | 1.35% | 0.48% |
#24
20
Prev: #44
|
3.5 |
—
|
500,000 | 54.4% |
P
S
|
1,419,493 | $66,772,951 | 2026 Q1 | 13F Filing | 2026-06-30 | 2026-08-13 | |||
|
STOK
Stoke Therapeut...
|
Healthcare | 1.32% | 1.80% |
#25
9
Prev: #16
|
1.5 |
—
|
no change | no change |
P
S
|
1,995,347 | $65,287,754 | 2024 Q4 | 13F Filing | 2026-06-30 | 2026-08-13 | |||
|
IRON
Disc Medicine I...
|
Healthcare | 1.31% | 1.75% |
#26
7
Prev: #19
|
1.0 |
—
|
-100,000 | -10.1% |
P
S
|
888,401 | $64,977,649 | 2025 Q1 | 13F Filing | 2026-06-30 | 2026-08-13 | |||
|
CYTK
Cytokinetics In...
|
Healthcare | 1.31% | 1.12% |
#27
2
Prev: #25
|
3.0 |
—
|
145,000 | 23.6% |
P
S
|
758,952 | $64,655,121 | 2024 Q3 | 13F Filing | 2026-06-30 | 2026-08-13 | |||
|
SEPN
Septerna Inc
|
Healthcare | 1.29% | 1.33% |
#28
6
Prev: #22
|
1.0 |
—
|
-100,000 | -5.0% |
P
S
|
1,900,000 | $63,631,000 | 2024 Q4 | 13F Filing | 2026-06-30 | 2026-08-13 | |||
|
OLMA
Olema Pharmaceu...
|
Healthcare | 1.23% | 1.97% |
#29
17
Prev: #12
|
1.0 |
—
|
100,000 | 2.1% |
P
S
|
4,856,949 | $60,760,432 | 2025 Q4 | 13F Filing | 2026-06-30 | 2026-08-13 | |||
|
CRNX
Crinetics Pharm...
|
Healthcare | 1.08% | 1.92% |
#30
17
Prev: #13
|
0.4 |
—
|
-482,848 | -25.4% |
P
S
|
1,420,788 | $53,165,887 | 2024 Q3 | 13F Filing | 2026-06-30 | 2026-08-13 | |||
|
N/A
Kailera Therape...
|
|
Unknown | 0.99% | — |
#31
Prev: #—
|
3.9 |
—
|
2,214,286 | — |
NEW
|
2,214,286 | $48,780,721 | — | 13F Filing | 2026-06-30 | 2026-08-13 | ||
|
DYN
Dyne Therapeuti...
|
Healthcare | 0.96% | 1.12% |
#32
6
Prev: #26
|
0.9 |
—
|
-100,000 | -4.5% |
P
S
|
2,129,125 | $47,287,866 | 2024 Q3 | 13F Filing | 2026-06-30 | 2026-08-13 | |||
|
GPCR
Structure Thera...
|
Healthcare | 0.95% | 1.78% |
#33
15
Prev: #18
|
0.4 |
—
|
-455,731 | -34.3% |
P
S
|
872,967 | $46,852,139 | 2025 Q3 | 13F Filing | 2026-06-30 | 2026-08-13 | |||
|
TBLA
Taboola.com Ltd
|
Communication Services | 0.85% | 0.86% |
#34
2
Prev: #32
|
0.8 |
—
|
-1,546,085 | -15.5% |
P
S
|
8,423,410 | $42,117,050 | 2024 Q3 | 13F Filing | 2026-06-30 | 2026-08-13 | |||
|
PVLA
Palvella Therap...
|
Healthcare | 0.80% | 0.89% |
#35
4
Prev: #31
|
1.3 |
—
|
no change | no change |
P
S
|
257,485 | $39,348,858 | 2025 Q4 | 13F Filing | 2026-06-30 | 2026-08-13 | |||
|
SLN
Silence Therape...
|
Healthcare | 0.74% | 0.43% |
#36
15
Prev: #51
|
2.3 |
—
|
400,000 | 13.7% |
P
S
|
3,311,438 | $36,359,589 | 2024 Q3 | 13F Filing | 2026-06-30 | 2026-08-13 | |||
|
DNLI
Denali Therapeu...
|
Healthcare | 0.73% | 0.74% |
#37
3
Prev: #34
|
1.3 |
—
|
no change | no change |
P
S
|
1,396,513 | $35,918,314 | 2024 Q3 | 13F Filing | 2026-06-30 | 2026-08-13 | |||
|
RELY
Remitly Global ...
|
Technology | 0.70% | 0.67% |
#38
3
Prev: #35
|
1.3 |
—
|
no change | no change |
P
S
|
1,543,271 | $34,584,703 | 2024 Q3 | 13F Filing | 2026-06-30 | 2026-08-13 | |||
|
CGEM
Cullinan Therap...
|
Healthcare | 0.70% | 0.47% |
#39
7
Prev: #46
|
3.3 |
—
|
700,000 | 58.7% |
P
S
|
1,893,410 | $34,478,996 | 2024 Q3 | 13F Filing | 2026-06-30 | 2026-08-13 | |||
|
COF
Capital One Fin...
|
Financial Services | 0.70% | — |
#40
Prev: #—
|
3.8 |
—
|
171,615 | — |
NEW
|
171,615 | $34,429,401 | 2026 Q2 | 13F Filing | 2026-06-30 | 2026-08-13 | |||
|
TRVI
Trevi Therapeut...
|
Healthcare | 0.67% | 0.59% |
#41
2
Prev: #39
|
1.3 |
—
|
no change | no change |
P
S
|
1,786,867 | $33,325,070 | 2024 Q4 | 13F Filing | 2026-06-30 | 2026-08-13 | |||
|
ORIC
Oric Pharmaceut...
|
Healthcare | 0.66% | 1.05% |
#42
13
Prev: #29
|
1.3 |
—
|
no change | no change |
P
S
|
2,998,192 | $32,470,419 | 2024 Q3 | 13F Filing | 2026-06-30 | 2026-08-13 | |||
|
GOOGL
Alphabet Inc
|
Communication Services | 0.65% | 0.52% |
#43
2
Prev: #41
|
2.8 |
—
|
24,297 | 37.0% |
P
S
|
90,000 | $32,163,300 | 2024 Q3 | 13F Filing | 2026-06-30 | 2026-08-13 | |||
|
DBVT
Dbv Technologie...
|
Healthcare | 0.62% | 1.08% |
#44
16
Prev: #28
|
1.2 |
—
|
no change | no change |
P
S
|
1,857,362 | $30,460,737 | 2025 Q4 | 13F Filing | 2026-06-30 | 2026-08-13 | |||
|
ABSI
Absci Corp
|
Healthcare | 0.58% | 0.15% |
#45
30
Prev: #75
|
2.7 |
—
|
674,764 | 37.5% |
P
S
|
2,474,764 | $28,682,515 | 2026 Q1 | 13F Filing | 2026-06-30 | 2026-08-13 | |||
|
SION
Sionna Therapeu...
|
Healthcare | 0.54% | 0.33% |
#46
9
Prev: #55
|
3.2 |
—
|
310,515 | 103.5% |
P
S
|
610,515 | $26,856,555 | 2025 Q1 | 13F Filing | 2026-06-30 | 2026-08-13 | |||
|
RAPP
Rapport Therape...
|
Healthcare | 0.54% | 0.56% |
#47
7
Prev: #40
|
1.2 |
—
|
no change | no change |
P
S
|
641,469 | $26,730,013 | 2024 Q3 | 13F Filing | 2026-06-30 | 2026-08-13 | |||
|
AMLX
Amylyx Pharmace...
|
Healthcare | 0.54% | 0.47% |
#48
3
Prev: #45
|
2.7 |
—
|
250,586 | 20.4% |
P
S
|
1,480,586 | $26,591,325 | 2026 Q1 | 13F Filing | 2026-06-30 | 2026-08-13 | |||
|
ANNX
Annexon Inc
|
Healthcare | 0.52% | 0.61% |
#49
11
Prev: #38
|
2.2 |
—
|
500,000 | 12.6% |
P
S
|
4,458,646 | $25,458,869 | 2026 Q1 | 13F Filing | 2026-06-30 | 2026-08-13 | |||
|
MNPR
Monopar Therape...
|
Healthcare | 0.51% | 0.41% |
#50
3
Prev: #53
|
1.2 |
—
|
no change | no change |
P
S
|
270,118 | $25,010,226 | 2025 Q4 | 13F Filing | 2026-06-30 | 2026-08-13 |
Showing 1-50 of 127 holdings