Siren, L.L.C.

All Holdings — 2025 Q4

Portfolio Concentration Analytics: 7.6
Risk-based ENB:
Total Positions
141
Quarter
2025 Q4
Top Holding
SRRK (14.2%)
Top 10 Concentration
46.3%
Turnover Rate
23.4%
Sector HHI
0.18
Items per page:
1-25 of 141
Stock History Sector / Type Port % Prev % Rank / Prev Conviction Change % Change Influence Shares Mkt Value Avg Cost Price Held 1st Owned Source Source Date Date Reported
SRRK
Scholar Rock Ho...
Healthcare 14.22% 13.48% #1
Prev: #1
7.7 1,575,008 17.0%
P
S
10,825,013 $476,841,823 2024 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
KYMR
Kymera Therapeu...
Healthcare 7.63% 7.59% #2
Prev: #2
3.1 -141,320 -4.1%
P
S
3,286,830 $255,748,242 2024 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
ONC
BeOne Medicines...
Healthcare 4.53% 6.57% #3
Prev: #3
3.8 7,010 1.4%
P
S
500,000 $151,905,000 2024 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
EWTX
Edgewise Therap...
Healthcare 3.35% 2.47% #4 4
Prev: #8
3.4 632,891 16.2%
P
S
4,529,990 $112,411,702 2024 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
RVMD
Revolution Medi...
Healthcare 3.17% 1.91% #5 12
Prev: #17
3.4 291,355 27.9%
P
S
1,335,075 $106,338,724 2024 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
CNTA
Centessa Pharma...
Healthcare 3.00% 3.06% #6
Prev: #6
3.3 800,000 24.8%
P
S
4,027,517 $100,728,200 2024 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
ARWR
Arrowhead Pharm...
Healthcare 2.97% 3.60% #7 3
Prev: #4
1.3 -1,169,404 -43.8%
P
S
1,500,476 $99,616,602 2024 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
BCAX
Bicara Therapeu...
Healthcare 2.62% 3.22% #8 3
Prev: #5
1.0 no change no change
P
S
5,216,969 $87,801,588 2024 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
OLMA
Olema Pharmaceu...
Healthcare 2.46% #9
Prev: #—
3.0 3,300,700 no change
NEW
3,300,700 $82,517,500 2025 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
IRON
Disc Medicine I...
Healthcare 2.34% 2.36% #10 1
Prev: #9
3.0 75,000 8.2%
P
S
988,401 $78,488,923 2025 Q1 13F Filing 2025-12-31 2026-02-14 (Est.)
GPCR
Structure Thera...
Healthcare 2.24% 1.12% #11 17
Prev: #28
2.9 51,887 5.1%
P
S
1,078,698 $75,023,446 2025 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
TNGX
Tango Therapeut...
Healthcare 2.16% 1.93% #12 4
Prev: #16
3.0 2,282,186 38.8%
P
S
8,165,374 $72,345,214 2024 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
RCUS
Arcus Bioscienc...
Healthcare 2.14% 1.55% #13 9
Prev: #22
2.9 95,000 3.3%
P
S
3,007,077 $71,658,645 2024 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
STOK
Stoke Therapeut...
Healthcare 2.13% 2.07% #14 1
Prev: #13
0.9 no change no change
P
S
2,247,347 $71,330,794 2024 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
CRNX
Crinetics Pharm...
Healthcare 2.09% 2.75% #15 8
Prev: #7
0.9 -180,975 -10.7%
P
S
1,507,636 $70,180,456 2024 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
DYN
Dyne Therapeuti...
Healthcare 2.04% 2.34% #16 6
Prev: #10
0.9 -1,226,233 -25.9%
P
S
3,502,941 $68,517,526 2024 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
APLS
Apellis Pharmac...
Healthcare 1.93% 2.28% #17 6
Prev: #11
0.8 no change no change
P
S
2,578,396 $64,769,308 2024 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
COGT
Cogent Bioscien...
Healthcare 1.73% 0.97% #18 13
Prev: #31
0.7 -95,000 -5.5%
P
S
1,629,279 $57,871,990 2025 Q2 13F Filing 2025-12-31 2026-02-14 (Est.)
SEPN
Septerna Inc
Healthcare 1.66% 1.62% #19 2
Prev: #21
0.7 -202,514 -9.2%
P
S
2,000,000 $55,760,000 2024 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
TSHA
Taysha Gene The...
Healthcare 1.66% 1.41% #20 3
Prev: #23
0.7 -884,824 -8.0%
P
S
10,129,913 $55,714,522 2024 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
RYTM
Rhythm Pharmace...
Healthcare 1.60% 1.98% #21 6
Prev: #15
0.6 no change no change
P
S
499,975 $53,517,324 2025 Q1 13F Filing 2025-12-31 2026-02-14 (Est.)
ASND
Ascendis Pharma...
Healthcare 1.50% 1.83% #22 4
Prev: #18
0.6 no change no change
P
S
235,862 $50,295,213 2024 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
RAPT
RAPT Therapeuti...
Healthcare 1.39% 0.59% #23 17
Prev: #40
2.9 794,534 136.9%
P
S
1,375,000 $46,571,250 2025 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
TBLA
Taboola.com Ltd
Communication Services 1.37% 1.33% #24
Prev: #24
0.5 no change no change
P
S
9,969,495 $45,959,372 2024 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
LXRX
Lexicon Pharmac...
Healthcare 1.34% 2.06% #25 11
Prev: #14
0.5 no change no change
P
S
38,918,903 $44,756,738 2024 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
RNA
Avidity Bioscie...
Healthcare 0.00% 2.19%
Sold All 😨
(Was: #12)
0.3 -1,285,610 -100.0%
CLOSED
$— 2024 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
RZLT
Rezolute Inc
Healthcare 0.00% 1.79%
Sold All 😨
(Was: #19)
0.3 -4,870,000 -100.0%
CLOSED
$— 2025 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
SLNO
Soleno Therapeu...
Healthcare 0.00% 1.24%
Sold All 😨
(Was: #26)
0.3 -467,342 -100.0%
CLOSED
$— 2024 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
NAMS
NewAmsterdam Ph...
Healthcare 0.00% 0.85%
Sold All 😨
(Was: #33)
0.3 -765,705 -100.0%
CLOSED
$— 2024 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
QURE
Uniqure NV
Healthcare 0.00% 0.63%
Sold All 😨
(Was: #37)
0.3 -275,200 -100.0%
CLOSED
$— 2025 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
AVBP
Arrivent Biopha...
Healthcare 0.00% 0.51%
Sold All 😨
(Was: #43)
0.3 -700,000 -100.0%
CLOSED
$— 2025 Q2 13F Filing 2025-12-31 2026-02-14 (Est.)
RNAC
Cartesian Thera...
Healthcare 0.00% 0.23%
Sold All 😨
(Was: #60)
0.3 -563,272 -100.0%
CLOSED
$— 2024 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
ELDN
Eledon Pharmace...
Healthcare 0.00% 0.21%
Sold All 😨
(Was: #62)
0.3 -2,072,767 -100.0%
CLOSED
$— 2025 Q1 13F Filing 2025-12-31 2026-02-14 (Est.)
PRQR
ProQR Therapeut...
Healthcare 0.00% 0.13%
Sold All 😨
(Was: #77)
0.3 -1,552,183 -100.0%
CLOSED
$— 2024 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
BIOA
BIOAGE Labs Inc
Healthcare 0.00% 0.09%
Sold All 😨
(Was: #87)
0.3 -382,406 -100.0%
CLOSED
$— 2024 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
KDP
Keurig Dr Peppe...
Consumer Defensive 0.00% 0.08%
Sold All 😨
(Was: #88)
0.3 -77,050 -100.0%
CLOSED
$— 2025 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
HUBS
HubSpot Inc
Technology 0.00% 0.07%
Sold All 😨
(Was: #89)
0.3 -4,000 -100.0%
CLOSED
$— 2025 Q2 13F Filing 2025-12-31 2026-02-14 (Est.)
CMG
Chipotle Mexica...
Consumer Cyclical 0.00% 0.07%
Sold All 😨
(Was: #90)
0.3 -47,500 -100.0%
CLOSED
$— 2025 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
SPOT
Spotify Technol...
Communication Services 0.00% 0.06%
Sold All 😨
(Was: #95)
0.3 -2,173 -100.0%
CLOSED
$— 2025 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
N/A
NIQ Global Inte...
Unknown 0.00% 0.06%
Sold All 😨
(Was: #96)
0.3 -95,000 -100.0%
CLOSED
$— 13F Filing 2025-12-31 2026-02-14 (Est.)
SAIL
SailPoint Inc
Technology 0.00% 0.04%
Sold All 😨
(Was: #98)
0.3 -50,000 -100.0%
CLOSED
$— 2025 Q1 13F Filing 2025-12-31 2026-02-14 (Est.)
ESTC
Elastic NV
Technology 0.00% 0.04%
Sold All 😨
(Was: #99)
0.3 -12,500 -100.0%
CLOSED
$— 2024 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
SEMR
SEMrush Holding...
Technology 0.00% 0.03%
Sold All 😨
(Was: #101)
0.3 -125,000 -100.0%
CLOSED
$— 2024 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
AS
Amer Sports Inc
Consumer Cyclical 0.00% 0.03%
Sold All 😨
(Was: #102)
0.3 -25,000 -100.0%
CLOSED
$— 2025 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
PINS
Pinterest Inc
Communication Services 0.00% 0.03%
Sold All 😨
(Was: #103)
0.3 -25,000 -100.0%
CLOSED
$— 2025 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
CFLT
Confluent Inc
Technology 0.00% 0.03%
Sold All 😨
(Was: #105)
0.3 -37,500 -100.0%
CLOSED
$— 2025 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
PCOR
Procore Technol...
Technology 0.00% 0.03%
Sold All 😨
(Was: #106)
0.3 -10,000 -100.0%
CLOSED
$— 2024 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
ALAB
Astera Labs Inc
Technology 0.00% 0.03%
Sold All 😨
(Was: #107)
0.3 -3,500 -100.0%
CLOSED
$— 2025 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
CHYM
Chime Financial...
Technology 0.00% 0.02%
Sold All 😨
(Was: #109)
0.3 -25,000 -100.0%
CLOSED
$— 2025 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
CCCS
CCC Intelligent...
Unknown 0.00% 0.02%
Sold All 😨
(Was: #110)
0.3 -50,000 -100.0%
CLOSED
$— 2025 Q2 13F Filing 2025-12-31 2026-02-14 (Est.)
KVUE
Kenvue Inc
Consumer Defensive 0.00% 0.02%
Sold All 😨
(Was: #111)
0.3 -25,000 -100.0%
CLOSED
$— 2025 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
VRT
Vertiv Holdings...
Industrials 0.00% 0.01%
Sold All 😨
(Was: #112)
0.3 -2,000 -100.0%
CLOSED
$— 2025 Q2 13F Filing 2025-12-31 2026-02-14 (Est.)
IRWD
Ironwood Pharma...
Healthcare 0.00% 0.01%
Sold All 😨
(Was: #115)
0.3 -110,532 -100.0%
CLOSED
$— 2024 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
Showing 1-25 of 141 holdings

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