Stock Analysis
Data Source: SEC EDGAR 13F
Updated Hourly

Septerna Inc (SEPN)

149 + Investors. Track Smart Money conviction in SEPN. See who's accumulating, reducing, or initiating positions.

Current Price
-- USD
Analyst Target
-- (0 analysts)
Upside
0.00%
Net Flow Q/Q
↑ +31
Streak
1Q ▲
Buyers last Q
66%

Smart Money Signals — SEPN

Based on 154 hedge funds · latest filing: 2026 Q2 · updated quarterly

📈

Buying streak — 1 quarter in a row

last 6Q
For 1 consecutive quarter, more hedge funds added SEPN than sold it. That's a consistent pattern of professional buying — not a one-time trade. When institutions keep buying quarter after quarter, it usually means they see a multi-year opportunity, not just a short-term momentum flip.
🏔️

At the ownership peak (100% of max)

100% of all-time peak
154 hedge funds hold SEPN right now — the highest count in 3.0 years. When ownership is this concentrated, any bad news can trigger a chain reaction: one big fund sells, others follow. This is a classic 'crowded trade' — high popularity doesn't equal safety.
🚀

Fast accumulation — +73% more funds vs a year ago

fund count last 6Q
+65 new funds entered over the past year (+73% YoY). That's a rapid rush of institutional money. Fast accumulation often signals a major thesis — but it also means the stock could fall quickly if that thesis breaks.
🟢

More buyers than sellers — 66% buying

100 buying51 selling
Last quarter: 100 funds were net buyers (50 opened a brand new position + 50 added to an existing one). Only 51 were sellers (32 trimmed + 19 sold completely). A clear majority buying is a strong confirmation signal.
📈

More new buyers each quarter (+24 vs last Q)

new funds entering per quarter
Funds opening a new SEPN position: 10 → 45 → 26 → 50. A growing influx of new institutional buyers means the asset is still gathering momentum — the consensus hasn't fully saturated yet.
🔄

Mostly new holders — 51% entered in last year

■ 5% conviction (2yr+) ■ 45% medium ■ 51% new
Only 7 funds (5%) have held >2 years. The majority of current holders are relatively new to the position. New holders tend to sell faster when prices drop — a shallow conviction base that could amplify any sell-off.
💰

Value +49% but shares only +7% — price-driven

Value
+49%
Shares
+7%
Last quarter: the total dollar value of institutional holdings rose +49%, but actual share count only changed +7%. The gap is explained by the stock's price rising — not new buying. Strong value growth with weak share growth means the rally is price momentum, not fresh institutional demand.
📈

Growing discovery — still being found

25 → 10 → 45 → 26 → 50 new funds/Q
New funds entering each quarter: 10 → 45 → 26 → 50. A growing number of institutions are discovering SEPN each quarter. The narrative is still spreading — leaving room for ongoing capital accumulation.
🌱

Early stage — 59% of holders entered in last year

■ 4% veterans ■ 37% 1-2yr ■ 59% new
Of 161 current holders: 95 (59%) entered in the past year, only 6 (4%) are 2+ year veterans. This is an early-phase institutional idea — still being discovered. High upside potential if the thesis plays out, but thin conviction base.
✅

Strong quality — 20% AUM from major funds

20% from top-100 AUM funds
43 of 151 holders rank in the top 100 by AUM, accounting for 20% of total institutional value held. A meaningful share of the ownership value comes from the most well-resourced institutions.
5.1
out of 10
Moderate Exit Risk
Exit risk score 5.1/10 — some crowding factors present, but no critical concentration. Watch ownership trend over the next 1–2 quarters for direction.

Methodology note: these Smart Money cards use consecutive 13F disclosure snapshots, not trade-by-trade execution data. "Buying", "selling", "new holders", and "trimmed" refer to quarter-over-quarter changes in reported holders, aggregate shares, or disclosed position values between filings. They are useful for ownership regime analysis and crowding, but they do not imply exact trade timing on the filing date.

Institutional Sentiment Summary — SEPN

In 2026 Q2, 100 hedge funds were net buyers of SEPN (50 opened a new position, 50 added to an existing one), while 51 reduced or exited (32 trimmed, 19 sold completely) — a 66% buyer ratio, indicating clear institutional accumulation. 20% of total institutional value in SEPN is held by top-100 AUM funds, reflecting strong institutional quality. Net fund flow last quarter: +31 funds (more new holders than closures). Total institutional holders: 154.

Hedge Fund Ownership: SEPN

How many hedge funds hold SEPN — quarterly history vs. share price
Quarterly hedge fund ownership of SEPN vs. share price

Market Analysis: SEPN

Analyst Price Targets

Avg. Price Target
--

Analyst Recommendations

Stock Performance

Real-time

Company Profile: SEPN

-- --

Institutional ownership data sourced from SEC EDGAR Form 13F-HR filings.

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Smart Money Signal ?
Limited Smart Money Interest

No strong consensus or elite conviction detected among institutional holders.

6 top-rated funds 5 high-conviction
Consensus
3.7
/ 10
breadth
×
Elite
3.6
/ 10
conviction
Hedge Fund Positioning: SEPN
149 + Investors

Track Smart Money conviction in SEPN. See who's accumulating, reducing, or initiating positions.

Metric All 13F Filers (2026 Q2) Prior (2026 Q1) Change
Funds Holding 149 123 21.14%
13F Shares 49M 46M 6.34%
Total Value $1.63B $1.10B 48.25%
New Positions 49 26 +23
Increased Positions 49 42 +7
Closed Positions 20 27 -7
Reduced Positions 31 31 -
Total Calls 5 1 400.0%
Total Puts 5 0 100%
PUT/CALL Ratio 1.0 0.0 Neutral

Statistics: SEPN

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Short % of Float --

Financial Highlights

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Institutional Holders (2026 Q2)

149 + investors

Explore institutional interest and hedge fund ownership dynamics. Analyze portfolio weights, new positions, and conviction trends in SEPN. Verified SEC 13F-HR filings.

QUARTER:
Top 25 SEPN holders by conviction (% of portfolio weight) — 2026 Q2 · Source: SEC Form 13F
# Investor % of Portfolio Shares Mkt Value
1 Trv GP VI, LLC 60.72% 4,211,659 $141.0M
2 Trv GP V, LLC 41.78% 6,215,591 $208.2M
3 Samsara BioCapital, LLC 8.66% 3,149,128 $105.5M
4 Kalehua Capital Management LLC 4.67% 194,544 $6.5M
5 Catalio Capital Management, LP 3.37% 536,152 $18.0M
6 Ra Capital Management, L.P. 2.04% 6,995,858 $234.3M
7 First Light Asset Management, LLC 1.96% 963,260 $32.3M
8 ADAR1 Capital Management, LLC 1.44% 940,747 $31.5M
9 Siren, L.L.C. 1.29% 1,900,000 $63.6M
10 Casdin Capital, LLC 0.93% 553,268 $18.5M
11 Driehaus Capital Management LLC 0.86% 4,433,058 $148.5M
12 Hussman Strategic Advisors, INC. 0.49% 63,000 $2.1M
13 Verdad Advisers, LP 0.42% 12,970 $434K
14 Elmind Capital, LP 0.42% 49,444 $1.7M
15 Avoro Capital Advisors LLC 0.40% 1,337,500 $44.8M
16 Soleus Capital Management, L.P. 0.32% 275,000 $9.2M
17 Diadema Partners LP 0.25% 59,700 $2.0M
18 HighVista Strategies LLC 0.22% 29,337 $982K
19 Rangeley Capital, LLC 0.22% 7,200 $241K
20 Longaeva Partners L.P. 0.22% 298,171 $10.0M
21 Algert Global LLC 0.16% 397,487 $13.3M
22 Fox Run Management, L.L.C. 0.12% 22,038 $738K
23 Chung Wu Investment Group, LLC 0.11% 4,800 $161K
24 Sofinnova Investments, Inc. 0.08% 47,506 $1.6M
25 Virtus Investment Advisers, LLC 0.07% 9,102 $305K
Investor Ownership
History 		% of Portfolio Prev % Rank Conviction Avg Buy Price 13F Score™ 3Y / 7Y Sell Timing Shares Mkt Value Change Change % Source Quarter Filed

Frequently Asked Questions — Septerna Inc (SEPN)

What does the Smart Money Trend signal show for SEPN?

Buying streak — 1 quarter in a row: For 1 consecutive quarter, more hedge funds added SEPN than sold it. That's a consistent pattern of professional buying — not a one-time trade. When institutions keep buying quarter after quarter, it usually means they see a multi-year opportunity, not just a short-term momentum flip.

What is the institutional breadth score for SEPN?

More buyers than sellers — 66% buying: Last quarter: 100 funds were net buyers (50 opened a brand new position + 50 added to an existing one). Only 51 were sellers (32 trimmed + 19 sold completely). A clear majority buying is a strong confirmation signal.

What is the fund quality score for SEPN holders?

Strong quality — 20% AUM from major funds: 43 of 151 holders rank in the top 100 by AUM, accounting for 20% of total institutional value held. A meaningful share of the ownership value comes from the most well-resourced institutions.

How long have hedge funds held SEPN?

Mostly new holders — 51% entered in last year: Only 7 funds (5%) have held >2 years. The majority of current holders are relatively new to the position. New holders tend to sell faster when prices drop — a shallow conviction base that could amplify any sell-off.

Where does this institutional ownership data come from?

All holdings data is sourced from SEC Form 13F filings, which institutional investment managers with over $100 million in assets are required to submit quarterly. Data is parsed directly from SEC EDGAR.

Disclaimer: The information on this page is for informational purposes only and does not constitute investment advice, a recommendation, or an offer to buy or sell any security. Institutional holdings data is sourced from SEC Form 13F filings and reflects positions as of the filing date. Past performance of any fund or portfolio is not indicative of future results. 13Foresight is not a registered investment adviser. Always conduct your own due diligence before making investment decisions.

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