RTW INVESTMENTS, LP — 13F Holdings

2026 Q1  ·  99 Positions

2026 Q1 Portfolio Activity

In 2026 Q1, RTW INVESTMENTS, LP maintained a portfolio of 99 distinct positions. The most significant new addition was WAYSTAR HLDG CORP, now representing 0.39% of the total fund value. They heavily accumulated shares in CG ONCOLOGY INC, increasing the position by 247.1%. Conversely, RTW INVESTMENTS, LP completely exited their position in PENUMBRA INC.
Position History hover any row below to update
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RTW INVESTMENTS, LP New York, NY Hedge Fund AUM $10,050M
PCA Score Concentration Risk
Risk ENB
Total Positions
99
Quarter
2026 Q1
Top Holding
MDGL (10.4%)
Top 10 Concentration
50.0%
Turnover Rate
23.4%
Sector HHI
0.18
Items per page:
Showing 1-50 of 99

RTW INVESTMENTS, LP Full Holdings List — 2026 Q1

Stock History Sector / Type Port % Prev % Rank / Prev Conviction
Freshness
Change % Change Influence Shares Mkt Value Avg Cost Price Held 1st Owned Source Source Date Date Reported
MDGL
MADRIGAL PHARMA...
Healthcare 10.38% 11.63% #1
Prev: #1
7.0
no change no change
P
S
1,993,687 $1,043,635,334
$258.33 +88.5%
$523.47 -7.0%
2023 Q2 13F Filing 2026-03-31 2026-05-15
INSM
INSMED INC
Healthcare 7.88% 8.44% #2
Prev: #2
5.2
1 0.0%
P
S
4,842,880 $791,907,738 2023 Q2 13F Filing 2026-03-31 2026-05-15
PTGX
PROTAGONIST THE...
Healthcare 5.31% 4.43% #3 2
Prev: #5
4.1
no change no change
P
S
5,059,053 $533,224,186 2019 Q3 13F Filing 2026-03-31 2026-05-15
PTCT
PTC THERAPEUTIC...
Healthcare 5.25% 5.89% #4 1
Prev: #3
3.6
no change no change
P
S
7,746,415 $527,763,254 2016 Q4 13F Filing 2026-03-31 2026-05-15
ARGX
ARGENX SE
Healthcare 5.16% 5.67% #5 1
Prev: #4
4.6
35,949 5.3%
P
S
709,446 $518,072,942 2017 Q2 13F Filing 2026-03-31 2026-05-15
CGON
CG ONCOLOGY INC
Healthcare 4.70% 0.84% #6 28
Prev: #34
4.9
4,972,681 247.1%
P
S
6,984,808 $472,731,805 2024 Q1 13F Filing 2026-03-31 2026-05-15
CELC
CELCUITY INC
Healthcare 3.45% 0.55% #7 40
Prev: #47
4.4
2,489,461 452.5%
P
S
3,039,621 $346,942,341 2025 Q4 13F Filing 2026-03-31 2026-05-15
TNGX
TANGO THERAPEUT...
Healthcare 2.77% 0.13% #8 59
Prev: #67
4.1
11,809,392 791.9%
P
S
13,300,620 $278,248,970 2021 Q3 13F Filing 2026-03-31 2026-05-15
ERAS
ERASCA INC
Healthcare 2.60% 0.01% #9 81
Prev: #90
4.0
16,010,524 10917.4%
P
S
16,157,175 $261,423,092 2025 Q4 13F Filing 2026-03-31 2026-05-15
NTRA
NATERA INC
Healthcare 2.49% 3.44% #10 4
Prev: #6
1.5
-250,000 -16.7%
P
S
1,250,000 $249,987,500 2015 Q3 13F Filing 2026-03-31 2026-05-15
RDNT
RADNET INC
Healthcare 2.38% 2.81% #11 4
Prev: #7
3.0
346,500 8.8%
P
S
4,285,000 $239,488,650 2023 Q4 13F Filing 2026-03-31 2026-05-15
TARS
TARSUS PHARMACE...
Healthcare 2.34% 2.74% #12 4
Prev: #8
1.4
10,705 0.3%
P
S
3,346,025 $234,723,654 2020 Q4 13F Filing 2026-03-31 2026-05-15
APGE
APOGEE THERAPEU...
Healthcare 2.33% 2.05% #13 1
Prev: #12
1.4
70,000 2.6%
P
S
2,782,097 $234,169,104 2023 Q3 13F Filing 2026-03-31 2026-05-15
SYRE
SPYRE THERAPEUT...
Healthcare 2.09% 1.37% #14 9
Prev: #23
1.8
no change no change
P
S
4,171,996 $210,435,478 2023 Q4 13F Filing 2026-03-31 2026-05-15
COGT
COGENT BIOSCIEN...
Healthcare 2.09% 2.70% #15 6
Prev: #9
0.8
-2,133,566 -28.1%
P
S
5,458,675 $210,104,401 2025 Q3 13F Filing 2026-03-31 2026-05-15
IRTC
IRHYTHM HOLDING...
Healthcare 1.96% 2.10% #16 5
Prev: #11
3.3
486,510 41.2%
P
S
1,668,500 $196,916,370 2025 Q4 13F Filing 2026-03-31 2026-05-15
STOK
STOKE THERAPEUT...
Healthcare 1.82% 1.76% #17 1
Prev: #16
1.2
76,669 1.4%
P
S
5,623,525 $183,101,974 2019 Q2 13F Filing 2026-03-31 2026-05-15
CYTK
CYTOKINETICS IN...
Healthcare 1.78% 1.73% #18
Prev: #18
1.7
no change no change
P
S
2,721,158 $179,351,524 2020 Q3 13F Filing 2026-03-31 2026-05-15
ACAD
ACADIA PHARMACE...
Healthcare 1.58% 1.91% #19 5
Prev: #14
1.6
no change no change
P
S
7,144,524 $159,037,104 2022 Q2 13F Filing 2026-03-31 2026-05-15
ESTA
ESTABLISHMENT L...
Healthcare 1.50% 1.89% #20 5
Prev: #15
1.1
66,864 2.6%
P
S
2,655,695 $150,790,362 2018 Q3 13F Filing 2026-03-31 2026-05-15
APLS
APELLIS PHARMAC...
Healthcare 1.48% 1.93% #21 8
Prev: #13
0.6
-3,981,719 -51.9%
P
S
3,685,045 $148,249,360 2021 Q4 13F Filing 2026-03-31 2026-05-15
IMCR
IMMUNOCORE HLDG...
Healthcare 1.46% 1.69% #22 3
Prev: #19
1.6
no change no change
P
S
4,869,798 $146,824,410 2021 Q1 13F Filing 2026-03-31 2026-05-15
RGEN
REPLIGEN CORP
Healthcare 1.41% 1.75% #23 6
Prev: #17
2.6
142,000 13.3%
P
S
1,206,000 $142,090,920 2025 Q4 13F Filing 2026-03-31 2026-05-15
NBIX
NEUROCRINE BIOS...
Healthcare 1.39% 1.51% #24 2
Prev: #22
1.6
no change no change
P
S
1,062,072 $139,917,365 2025 Q2 13F Filing 2026-03-31 2026-05-15
GH
GUARDANT HEALTH...
Healthcare 1.36% 1.52% #25 4
Prev: #21
1.5
no change no change
P
S
1,481,033 $136,803,018 2020 Q3 13F Filing 2026-03-31 2026-05-15
IMTX
IMMATICS N.V
Healthcare 1.26% 1.20% #26 1
Prev: #25
2.5
1,435,986 12.6%
P
S
12,869,340 $126,634,306 2020 Q3 13F Filing 2026-03-31 2026-05-15
ZLAB
ZAI LAB LTD
Healthcare 1.23% 1.23% #27 3
Prev: #24
1.0
-385,000 -5.5%
P
S
6,574,032 $123,657,542 2024 Q4 13F Filing 2026-03-31 2026-05-15
BLTE
BELITE BIO INC
Healthcare 1.13% 1.15% #28 2
Prev: #26
1.5
no change no change
P
S
715,332 $114,052,534 2025 Q3 13F Filing 2026-03-31 2026-05-15
ISRG
INTUITIVE SURGI...
Healthcare 1.01% 0.57% #29 16
Prev: #45
3.4
118,772 117.3%
P
S
220,000 $101,417,800 2023 Q2 13F Filing 2026-03-31 2026-05-15
ORKA
ORUKA THERAPEUT...
Healthcare 1.00% 0.62% #30 12
Prev: #42
1.4
no change no change
P
S
2,058,148 $100,952,159 2024 Q3 13F Filing 2026-03-31 2026-05-15
GHRS
GH RESEARCH PLC
Healthcare 0.83% 0.75% #31 7
Prev: #38
1.3
no change no change
P
S
5,933,815 $83,429,439 2021 Q2 13F Filing 2026-03-31 2026-05-15
XNCR
XENCOR INC
Healthcare 0.81% 1.04% #32 4
Prev: #28
1.3
no change no change
P
S
6,777,461 $81,736,180 2024 Q3 13F Filing 2026-03-31 2026-05-15
URGN
UROGEN PHARMA L...
Healthcare 0.81% 1.07% #33 6
Prev: #27
1.3
no change no change
P
S
4,543,895 $81,699,232 2021 Q3 13F Filing 2026-03-31 2026-05-15
CNTA
CENTESSA PHARMA...
Healthcare 0.81% 0.45% #34 16
Prev: #50
2.3
263,338 14.7%
P
S
2,054,175 $81,591,831 2024 Q3 13F Filing 2026-03-31 2026-05-15
IMVT
IMMUNOVANT INC
Healthcare 0.79% 0.81% #35 1
Prev: #36
0.8
-1 -0.0%
P
S
3,177,849 $78,937,769 2019 Q4 13F Filing 2026-03-31 2026-05-15
RARE
ULTRAGENYX PHAR...
Healthcare 0.76% 0.69% #36 4
Prev: #40
2.8
648,656 21.6%
P
S
3,648,795 $76,442,255 2021 Q4 13F Filing 2026-03-31 2026-05-15
HNGE
HINGE HEALTH IN...
Healthcare 0.74% 0.16% #37 26
Prev: #63
3.3
1,576,500 446.0%
P
S
1,930,000 $74,420,800 2025 Q4 13F Filing 2026-03-31 2026-05-15
CSTL
CASTLE BIOSCIEN...
Healthcare 0.67% 0.82% #38 3
Prev: #35
2.8
643,098 30.4%
P
S
2,758,335 $67,717,124 2019 Q3 13F Filing 2026-03-31 2026-05-15
RCKT
ROCKET PHARMACE...
Healthcare 0.63% 0.62% #39 4
Prev: #43
1.3
no change no change
P
S
17,687,772 $63,322,224 2018 Q1 13F Filing 2026-03-31 2026-05-15
TSHA
TAYSHA GENE THE...
Healthcare 0.61% 0.90% #40 10
Prev: #30
0.7
-2,718,049 -16.6%
P
S
13,680,248 $61,150,709 2023 Q3 13F Filing 2026-03-31 2026-05-15
ALKS
ALKERMES PLC
Healthcare 0.59% 0.47% #41 8
Prev: #49
1.2
no change no change
P
S
1,672,356 $59,134,508 2023 Q3 13F Filing 2026-03-31 2026-05-15
CMPS
COMPASS PATHWAY...
Healthcare 0.59% 0.61% #42 2
Prev: #44
2.7
1,875,000 21.4%
P
S
10,632,390 $58,797,117 2024 Q4 13F Filing 2026-03-31 2026-05-15
KOD
KODIAK SCIENCES...
Healthcare 0.56% 0.42% #43 8
Prev: #51
0.7
1 0.0%
P
S
1,487,934 $56,720,044 2025 Q4 13F Filing 2026-03-31 2026-05-15
REPL
REPLIMUNE GROUP...
Healthcare 0.56% 0.70% #44 5
Prev: #39
0.7
216,564 3.0%
P
S
7,356,916 $56,280,407 2024 Q2 13F Filing 2026-03-31 2026-05-15
CRNX
CRINETICS PHARM...
Healthcare 0.52% 0.63% #45 4
Prev: #41
2.2
100,000 7.4%
P
S
1,451,326 $52,712,160 2025 Q2 13F Filing 2026-03-31 2026-05-15
QURE
UNIQURE NV
Healthcare 0.42% 0.89% #46 14
Prev: #32
0.2
-1,125,106 -30.3%
P
S
2,586,356 $42,286,921 2017 Q4 13F Filing 2026-03-31 2026-05-15
WAY
WAYSTAR HLDG CO...
Healthcare 0.39% #47
Prev: #—
3.7
1,630,000
NEW
1,630,000 $39,299,300 2026 Q1 13F Filing 2026-03-31 2026-05-15
ARWR
ARROWHEAD PHARM...
Healthcare 0.37% 0.39% #48 5
Prev: #53
0.6
966 0.2%
P
S
585,682 $36,722,261 2014 Q4 13F Filing 2026-03-31 2026-05-15
OBIO
ORCHESTRA BIOME...
Healthcare 0.35% 0.35% #49 6
Prev: #55
1.1
no change no change
P
S
8,306,063 $35,300,768 2023 Q1 13F Filing 2026-03-31 2026-05-15
VSTM
VERASTEM INC
Healthcare 0.35% 0.51% #50 2
Prev: #48
1.1
no change no change
P
S
6,576,306 $34,854,422 2025 Q1 13F Filing 2026-03-31 2026-05-15
Showing 1-50 of 99 holdings

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