PERCEPTIVE ADVISORS LLC

All Holdings — 2025 Q4

AI Portfolio Summary
In 2025 Q4, PERCEPTIVE ADVISORS LLC maintained a portfolio of 131 distinct positions. The most significant new addition to the portfolio was SPDR SERIES TRUST, which now represents 2.39% of the total fund value. They heavily accumulated shares in PRAXIS PRECISION MED, increasing their position by 27.6%. Conversely, PERCEPTIVE ADVISORS LLC completely exited their position in RHYTHM PHARMACEUTICA.
PCA Score Concentration Risk
Risk ENB
Total Positions
131
Quarter
2025 Q4
Top Holding
PRAX (10.5%)
Top 10 Concentration
41.8%
Turnover Rate
23.4%
Sector HHI
0.18
Items per page:
Showing 1-50 of 131
Stock History Sector / Type Port % Prev % Rank / Prev Conviction Change % Change Influence Shares Mkt Value Avg Cost Price Held 1st Owned Source Source Date Date Reported
PRAX
PRAXIS PRECISIO...
Healthcare 10.49% 2.39% #1 12
Prev: #13
8.5 431,432 27.6%
P
S
1,995,986 $588,296,914 2024 Q1 13F Filing 2025-12-31 2026-02-14 (Est.)
CELC
CELCUITY INC
Healthcare 5.62% 4.22% #2 2
Prev: #4
5.7 203,881 6.9%
P
S
3,160,200 $315,198,348 2023 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
RYTM
RHYTHM PHARMACE...
Healthcare 4.86% 8.33% #3 2
Prev: #1
2.9 -416,558,578 -99.4%
P
S
2,546,391 $272,565,693 2017 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
ASND
ASCENDIS PHARMA...
Healthcare 4.11% 6.25% #4 2
Prev: #2
2.6 -7,080 -0.7%
P
S
1,081,421 $230,602,214 2015 Q1 13F Filing 2025-12-31 2026-02-14 (Est.)
APGE
APOGEE THERAPEU...
Healthcare 3.14% 1.55% #5 18
Prev: #23
4.8 978,662 72.4%
P
S
2,330,651 $175,917,537 2023 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
ROIV
ROIVANT SCIENCE...
Healthcare 3.09% 3.22% #6 2
Prev: #8
3.2 617,000 8.4%
P
S
7,985,461 $173,284,504 2022 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
NUVL
NUVALENT INC
Healthcare 2.99% 3.90% #7 2
Prev: #5
3.2 102,769 6.6%
P
S
1,665,105 $167,492,912 2021 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
TVTX
TRAVERE THERAPE...
Healthcare 2.91% 2.62% #8 3
Prev: #11
3.2 483,565 12.7%
P
S
4,278,180 $163,469,258 2020 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
XBI
SPDR SERIES TRU...
PUT
PUT Option 2.39% #9
Prev: #—
4.5 1,100,000 no change
NEW
1,100,000 $134,123,000 2015 Q2 13F Filing 2025-12-31 2026-02-14 (Est.)
EXAS
EXACT SCIENCES ...
Healthcare 2.17% 0.74% #10 29
Prev: #39
3.9 735,000 157.9%
P
S
1,200,487 $121,921,460 2010 Q1 13F Filing 2025-12-31 2026-02-14 (Est.)
PTGX
PROTAGONIST THE...
Healthcare 2.10% 1.98% #11 6
Prev: #17
3.3 320,291 31.1%
P
S
1,350,425 $117,946,120 2020 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
INBX
INHIBRX BIOSCIE...
Healthcare 2.05% 1.29% #12 15
Prev: #27
2.8 125,000 9.4%
P
S
1,452,707 $114,763,853 2021 Q2 13F Filing 2025-12-31 2026-02-14 (Est.)
EWTX
EDGEWISE THERAP...
Healthcare 1.97% 1.78% #13 6
Prev: #19
2.8 662,080 17.4%
P
S
4,457,974 $110,624,625 2023 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
IMTX
IMMATICS N.V
Healthcare 1.94% 2.31% #14
Prev: #14
2.8 1,000,000 10.7%
P
S
10,383,456 $109,026,288 2020 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
SYRE
SPYRE THERAPEUT...
Healthcare 1.79% 0.60% #15 30
Prev: #45
3.7 1,839,780 149.6%
P
S
3,069,225 $100,547,811 2023 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
AMLX
AMYLYX PHARMACE...
Healthcare 1.78% 3.51% #16 9
Prev: #7
1.2 -667,483 -7.5%
P
S
8,284,882 $100,081,375 2022 Q1 13F Filing 2025-12-31 2026-02-14 (Est.)
ACLX
ARCELLX INC
Healthcare 1.70% 5.85% #17 14
Prev: #3
0.7 -1,002,282 -40.6%
P
S
1,466,071 $95,587,829 2022 Q2 13F Filing 2025-12-31 2026-02-14 (Est.)
VRDN
VIRIDIAN THERAP...
Healthcare 1.69% 0.91% #18 15
Prev: #33
3.7 1,580,303 108.1%
P
S
3,042,703 $94,688,917 2021 Q2 13F Filing 2025-12-31 2026-02-14 (Est.)
BSX
BOSTON SCIENTIF...
Healthcare 1.66% 0.87% #19 16
Prev: #35
3.7 669,000 215.8%
P
S
979,000 $93,347,650 2004 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
FOLD
AMICUS THERAPEU...
Healthcare 1.62% 1.45% #20 5
Prev: #25
1.6 no change no change
P
S
6,370,851 $90,720,918 2007 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
ZYME
ZYMEWORKS INC
Healthcare 1.53% 1.03% #21 8
Prev: #29
3.6 1,171,187 56.0%
P
S
3,261,850 $85,884,511 2022 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
ATXS
ASTRIA THERAPEU...
Healthcare 1.51% 1.36% #22 4
Prev: #26
1.6 no change no change
P
S
6,485,420 $84,894,147 2021 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
MGTX
MEIRAGTX HLDGS ...
Healthcare 1.46% 3.00% #23 14
Prev: #9
1.1 -2,300,000 -18.2%
P
S
10,326,103 $82,092,519 2018 Q2 13F Filing 2025-12-31 2026-02-14 (Est.)
AORT
ARTIVION INC
Healthcare 1.40% 2.47% #24 12
Prev: #12
1.1 -297,710 -14.7%
P
S
1,722,290 $78,553,647 2016 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
CNTA
CENTESSA PHARMA...
Healthcare 1.30% 2.17% #25 10
Prev: #15
1.0 -183,268 -5.9%
P
S
2,917,634 $72,970,026 2024 Q1 13F Filing 2025-12-31 2026-02-14 (Est.)
DYN
DYNE THERAPEUTI...
Healthcare 1.21% 0.20% #26 42
Prev: #68
3.5 2,938,500 543.7%
P
S
3,478,944 $68,048,145 2020 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
NRIX
NURIX THERAPEUT...
Healthcare 1.20% 0.38% #27 24
Prev: #51
3.5 2,139,728 151.1%
P
S
3,555,877 $67,454,987 2024 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
SLDB
SOLID BIOSCIENC...
Healthcare 1.19% 2.11% #28 12
Prev: #16
1.5 no change no change
P
S
11,833,539 $66,741,160 2022 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
BLTE
BELITE BIO INC
Healthcare 1.18% 0.11% #29 46
Prev: #75
3.5 364,451 732.0%
P
S
414,239 $66,261,670 2025 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
ABVX
ABIVAX SA
Healthcare 1.10% 0.95% #30 2
Prev: #32
2.4 69,735 17.9%
P
S
458,343 $61,809,845 2025 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
IVVD
INVIVYD INC
Healthcare 0.96% #31
Prev: #—
3.9 21,785,166 no change
NEW
21,785,166 $53,809,360 2025 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
ENGN
ENGENE HOLDINGS...
Healthcare 0.94% 0.41% #32 17
Prev: #49
3.4 3,771,840 179.8%
P
S
5,869,076 $52,997,756 2024 Q1 13F Filing 2025-12-31 2026-02-14 (Est.)
RGEN
REPLIGEN CORP
Healthcare 0.92% 1.04% #33 5
Prev: #28
2.4 45,113 16.7%
P
S
315,541 $51,704,548 2002 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
IMVT
IMMUNOVANT INC
Healthcare 0.90% 0.74% #34 4
Prev: #38
2.9 407,000 25.6%
P
S
1,994,890 $50,710,104 2020 Q2 13F Filing 2025-12-31 2026-02-14 (Est.)
ISRG
INTUITIVE SURGI...
Healthcare 0.89% 0.67% #35 7
Prev: #42
3.4 35,800 68.7%
P
S
87,919 $49,793,805 2005 Q1 13F Filing 2025-12-31 2026-02-14 (Est.)
SION
SIONNA THERAPEU...
Healthcare 0.86% 1.00% #36 6
Prev: #30
1.3 no change no change
P
S
1,179,098 $48,508,092 2025 Q1 13F Filing 2025-12-31 2026-02-14 (Est.)
NBIX
NEUROCRINE BIOS...
Healthcare 0.84% 1.82% #37 19
Prev: #18
0.3 -119,000 -26.4%
P
S
331,050 $46,952,821 2006 Q1 13F Filing 2025-12-31 2026-02-14 (Est.)
DHR
DANAHER CORPORA...
Healthcare 0.82% #38
Prev: #—
3.8 200,000 no change
NEW
200,000 $45,784,000 2015 Q2 13F Filing 2025-12-31 2026-02-14 (Est.)
ORKA
ORUKA THERAPEUT...
Healthcare 0.80% 0.70% #39 2
Prev: #41
2.3 208,480 16.4%
P
S
1,476,501 $44,752,745 2024 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
CTMX
CYTOMX THERAPEU...
Healthcare 0.74% 0.89% #40 6
Prev: #34
1.3 no change no change
P
S
9,680,185 $41,237,588 2015 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
OMDA
OMADA HEALTH IN...
Healthcare 0.67% 1.53% #41 17
Prev: #24
1.3 no change no change
P
S
2,396,330 $37,814,087 2025 Q2 13F Filing 2025-12-31 2026-02-14 (Est.)
CDTX
CIDARA THERAPEU...
Healthcare 0.65% #42
Prev: #—
3.8 165,131 no change
NEW
165,131 $36,475,787 2025 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
IRON
DISC MEDICINE I...
Healthcare 0.64% #43
Prev: #—
3.8 450,743 no change
NEW
450,743 $35,793,502 2023 Q2 13F Filing 2025-12-31 2026-02-14 (Est.)
DRUG
BRIGHT MINDS BI...
Healthcare 0.62% 0.79% #44 7
Prev: #37
1.2 no change no change
P
S
449,290 $35,062,592 2024 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
PEN
PENUMBRA INC
Healthcare 0.61% 1.61% #45 24
Prev: #21
0.2 -110,018 -49.9%
P
S
110,529 $34,364,571 2018 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
ANRO
ALTO NEUROSCIEN...
Healthcare 0.57% 0.02% #46 42
Prev: #88
3.2 1,629,027 1048.5%
P
S
1,784,393 $31,762,195 2025 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
CAI
CARIS LIFE SCIE...
Healthcare 0.55% 0.96% #47 16
Prev: #31
0.7 38,043 3.5%
P
S
1,136,206 $30,654,838 2025 Q2 13F Filing 2025-12-31 2026-02-14 (Est.)
JAZZ
JAZZ PHARMACEUT...
Healthcare 0.52% #48
Prev: #—
3.7 170,000 no change
NEW
170,000 $28,900,000 2012 Q2 13F Filing 2025-12-31 2026-02-14 (Est.)
PALI
PALISADE BIO IN...
Healthcare 0.50% #49
Prev: #—
3.7 12,050,000 no change
NEW
12,050,000 $28,317,500 2025 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
RAPT
RAPT THERAPEUTI...
Healthcare 0.50% 0.14% #50 23
Prev: #73
3.2 642,000 349.1%
P
S
825,890 $27,972,894 2020 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
Showing 1-50 of 131 holdings

Unlock Full PERCEPTIVE ADVISORS LLC Analysis

PRO subscribers get access to all historical quarters, Excel/CSV exports, Portfolio Concentration Analytics (PCA), and Risk-Based ENB.

Full Historical Quarters
Excel & CSV Export
PCA & Risk-Based ENB
Auto Cost Basis
Position Change Alerts
Price-Held Analytics