Stock Analysis
Data Source: SEC EDGAR 13F
Updated Hourly

Zymeworks Inc (ZYME)

213 + Investors. Track Smart Money conviction in ZYME. See who's accumulating, reducing, or initiating positions.

Current Price
-- USD
Analyst Target
-- (0 analysts)
Upside
0.00%
Net Flow Q/Q
↑ +8
Streak
3Q ▲
Buyers last Q
56%

Smart Money Signals — ZYME

Based on 214 hedge funds · latest filing: 2026 Q1 · updated quarterly

📈

Buying streak — 3 quarters in a row

last 6Q
For 3 consecutive quarters, more hedge funds added ZYME than sold it. That's a consistent pattern of professional buying — not a one-time trade. When institutions keep buying quarter after quarter, it usually means they see a multi-year opportunity, not just a short-term momentum flip.
🏔️

At the ownership peak (100% of max)

100% of all-time peak
214 hedge funds hold ZYME right now — the highest count in 3.0 years. When ownership is this concentrated, any bad news can trigger a chain reaction: one big fund sells, others follow. This is a classic 'crowded trade' — high popularity doesn't equal safety.
📶

Steady growth — +16% more funds vs a year ago

fund count last 6Q
+29 new funds entered over the past year (+16% YoY). Gradual, steady growth in institutional ownership is generally a healthy signal — not a speculative rush, but consistent conviction.
🟡

Slight buying edge — 56% buying

119 buying94 selling
Last quarter: 119 funds bought or added vs 94 that reduced or exited. It's nearly a 50/50 split — some institutions are convinced, others are taking profits. This mixed picture is normal near price highs.
⚠️

Fewer new buyers each quarter (-6 vs last Q)

new funds entering per quarter
Funds opening this position for the first time: 28 → 25 → 46 → 40. Each quarter fewer new institutions are entering. This usually means most funds that wanted in are already in — the stock is well-known but the pool of potential new buyers is shrinking.
🔒

44% of holders stayed for 2+ years

■ 44% conviction (2yr+) ■ 28% medium ■ 29% new
94 out of 214 hedge funds have held ZYME for over 2 years without selling. Long-term investors are generally harder to shake out during market stress, creating a stable ownership base that limits the risk of sudden capitulation.
🚀

Acceleration phase — new buyers rushing in

34 → 28 → 25 → 46 → 40 new funds/Q
New funds entering each quarter: 28 → 25 → 46 → 40. The pace of institutional discovery is accelerating sharply. This is the 'hot idea' phase — the thesis is being passed from fund to fund. You are not late — the accumulation wave is still building.
🏛️

Veteran-anchored — 53% veterans vs 31% newcomers

■ 53% veterans ■ 16% 1-2yr ■ 31% new
Entry-cohort mix of 221 holders: 117 (53%) are 2+ year veterans, 35 entered 1–2 years ago, and 69 (31%) joined within the past year. A veteran-weighted cap table skews toward institutional memory over fresh momentum.
📋

Smaller funds dominant — 18% AUM from top-100

18% from top-100 AUM funds
50 of 211 holders rank in the top 100 by AUM, but together hold only 18% of total institutional value. The stock is held primarily by smaller and mid-sized funds.
4.0
out of 10
Moderate Exit Risk
Exit risk score 4.0/10 — some crowding factors present, but no critical concentration. Watch ownership trend over the next 1–2 quarters for direction.

Methodology note: these Smart Money cards use consecutive 13F disclosure snapshots, not trade-by-trade execution data. "Buying", "selling", "new holders", and "trimmed" refer to quarter-over-quarter changes in reported holders, aggregate shares, or disclosed position values between filings. They are useful for ownership regime analysis and crowding, but they do not imply exact trade timing on the filing date.

Institutional Sentiment Summary — ZYME

In 2026 Q1, 119 hedge funds were net buyers of ZYME (40 opened a new position, 79 added to an existing one), while 94 reduced or exited (62 trimmed, 32 sold completely) — a 56% buyer ratio, indicating a slight buying edge. This marks 3 consecutive quarters of net institutional buying — a persistent conviction signal. Net fund flow last quarter: +8 funds (more new holders than closures). Total institutional holders: 214.

Hedge Fund Ownership: ZYME

How many hedge funds hold ZYME — quarterly history vs. share price
Quarterly hedge fund ownership of ZYME vs. share price

Market Analysis: ZYME

Analyst Price Targets

Avg. Price Target
--

Analyst Recommendations

Stock Performance

Real-time

Company Profile: ZYME

-- --

Institutional ownership data sourced from SEC EDGAR Form 13F-HR filings.

Is It Too Late to Buy Zymeworks Inc (ZYME) Based on Hedge Fund 13F Filings?

Signal Freshness measures how much ZYME has moved relative to its sector benchmark (XLV) since the 2026 Q1 13F filing. A stock that has barely outrun its sector is still a relatively fresh entry point — the fund's thesis has not yet been priced in by the broader market.

Since Quarter End March 31, 2026 · 79d ago
ZYME
-10.2%
XLV
+2.1%

ZYME outperformed XLV by -12.3% since March 31, 2026.

Since 13F Filing Date May 15, 2026 · 34d ago
ZYME
-6.0%
XLV
+3.2%

Since the filing became public, ZYME outperformed XLV by -9.2% .

Interpretation: The stock is tracking its sector benchmark closely. The signal remains fresh and the entry point is still near the fund's implied reference. Learn more →

Smart Money Signal ?
Limited Smart Money Interest

No strong consensus or elite conviction detected among institutional holders.

26 top-rated funds 0 high-conviction
Consensus
6.2
/ 10
breadth
×
Elite
1.8
/ 10
conviction
Hedge Fund Positioning: ZYME
213 + Investors

Track Smart Money conviction in ZYME. See who's accumulating, reducing, or initiating positions.

Metric All 13F Filers (2026 Q1) Prior (2025 Q4) Change
Funds Holding 213 206 3.4%
13F Shares 71M 72M -2.07%
Total Value $1.77B $1.90B -7.05%
New Positions 39 46 -7
Increased Positions 75 73 +2
Closed Positions 32 22 +10
Reduced Positions 61 62 -1
Total Calls 6 6 -
Total Puts 4 6 -33.33%
PUT/CALL Ratio 0.67 1.0 Bullish

Statistics: ZYME

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Enterprise Value/EBITDA --
Beta (5Y Monthly) --
Short Ratio (Days to Cover) --
Short % of Float --

Financial Highlights

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Institutional Holders (2026 Q1)

213 + investors

Explore institutional interest and hedge fund ownership dynamics. Analyze portfolio weights, new positions, and conviction trends in ZYME. Verified SEC 13F-HR filings.

QUARTER:
Top 25 ZYME holders by conviction (% of portfolio weight) — 2026 Q1 · Source: SEC Form 13F
# Investor % of Portfolio Shares Mkt Value
1 EcoR1 Capital, LLC 24.41% 22,970,388 $575.2M
2 Capricorn Fund Managers Ltd 3.93% 1,007,210 $25.2M
3 Bvf Inc/Il 2.98% 3,734,142 $93.5M
4 Verdad Advisers, LP 2.33% 82,698 $2.1M
5 Prosight Management, LP 2.21% 539,049 $13.5M
6 Nextech Invest, Ltd. 1.96% 1,113,946 $27.9M
7 Rubric Capital Management LP 1.86% 7,000,000 $175.3M
8 Perceptive Advisors LLC 1.72% 3,510,078 $87.9M
9 MPM BioImpact LLC 1.09% 565,249 $14.2M
10 Redmile Group, LLC 0.82% 491,654 $12.3M
11 Platinum Investment Management Ltd 0.66% 105,184 $2.6M
12 Diadema Partners LP 0.61% 142,132 $3.6M
13 Persistent Asset Partners Ltd 0.34% 35,935 $900K
14 Granahan Investment Management, LLC 0.30% 250,773 $6.3M
15 Oxford Asset Management LLP 0.30% 27,812 $696K
16 Manatuck Hill Partners, LLC 0.27% 40,000 $1.0M
17 SummitTX Capital, L.P. 0.25% 321,427 $8.0M
18 HighVista Strategies LLC 0.24% 34,085 $853K
19 Hillsdale Investment Management Inc. 0.24% 345,622 $8.7M
20 PSP Research LLC 0.18% 10,000 $250K
21 Tema Etfs LLC 0.18% 104,931 $2.6M
22 Duncan Williams Asset Management, LLC 0.15% 22,095 $553K
23 Ewing Morris & Co. Investment Partners Ltd. 0.12% 10,850 $272K
24 DLD Asset Management, LP 0.12% 53,000 $1.3M
25 Kennedy Capital Management LLC 0.08% 148,226 $3.7M
Investor Ownership
History 		% of Portfolio Prev % Rank Conviction Avg Buy Price 13F Score™ 3Y / 7Y Sell Timing Shares Mkt Value Change Change % Source Quarter Filed

Frequently Asked Questions — Zymeworks Inc (ZYME)

What does the Smart Money Trend signal show for ZYME?

Buying streak — 3 quarters in a row: For 3 consecutive quarters, more hedge funds added ZYME than sold it. That's a consistent pattern of professional buying — not a one-time trade. When institutions keep buying quarter after quarter, it usually means they see a multi-year opportunity, not just a short-term momentum flip.

What is the institutional breadth score for ZYME?

Slight buying edge — 56% buying: Last quarter: 119 funds bought or added vs 94 that reduced or exited. It's nearly a 50/50 split — some institutions are convinced, others are taking profits. This mixed picture is normal near price highs.

What is the fund quality score for ZYME holders?

Smaller funds dominant — 18% AUM from top-100: 50 of 211 holders rank in the top 100 by AUM, but together hold only 18% of total institutional value. The stock is held primarily by smaller and mid-sized funds.

How long have hedge funds held ZYME?

44% of holders stayed for 2+ years: 94 out of 214 hedge funds have held ZYME for over 2 years without selling. Long-term investors are generally harder to shake out during market stress, creating a stable ownership base that limits the risk of sudden capitulation.

Is it too late to buy Zymeworks Inc (ZYME) following the 2026 Q1 hedge fund 13F filings?

As of today, ZYME has moved -6.0% since the 2026 Q1 13F filing date (May 15, 2026), compared to +3.2% for the XLV sector ETF — an outperformance of -9.2%. Since the quarter end (March 31, 2026), ZYME has gained -10.2% vs +2.1% for XLV. The stock is tracking its sector benchmark closely. The signal remains fresh and the entry point is still near the fund's implied reference.

Where does this institutional ownership data come from?

All holdings data is sourced from SEC Form 13F filings, which institutional investment managers with over $100 million in assets are required to submit quarterly. Data is parsed directly from SEC EDGAR.

Disclaimer: The information on this page is for informational purposes only and does not constitute investment advice, a recommendation, or an offer to buy or sell any security. Institutional holdings data is sourced from SEC Form 13F filings and reflects positions as of the filing date. Past performance of any fund or portfolio is not indicative of future results. 13Foresight is not a registered investment adviser. Always conduct your own due diligence before making investment decisions.

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