Stock Analysis
Data Source: SEC EDGAR 13F
Updated Hourly

ZYMEWORKS INC (ZYME)

210 + Investors. Track Smart Money conviction in ZYME. See who's accumulating, reducing, or initiating positions.

Current Price
-- USD
Analyst Target
-- (0 analysts)
Upside
0.00%
Net Flow Q/Q
↑ +24
Streak
2Q ▲
Buyers last Q
58%

Smart Money Signals — ZYME

Based on 200 hedge funds · latest filing: 2025 Q4 · updated quarterly

📈

Buying streak — 2 quarters in a row

last 6Q
For 2 consecutive quarters, more hedge funds added ZYME than sold it. That's a consistent pattern of professional buying — not a one-time trade. When institutions keep buying quarter after quarter, it usually means they see a multi-year opportunity, not just a short-term momentum flip.
🏔️

At the ownership peak (100% of max)

100% of all-time peak
200 hedge funds hold ZYME right now — the highest count in 3.0 years. When ownership is this concentrated, any bad news can trigger a chain reaction: one big fund sells, others follow. This is a classic 'crowded trade' — high popularity doesn't equal safety.
📶

Steady growth — +20% more funds vs a year ago

fund count last 6Q
+34 new funds entered over the past year (+20% YoY). Gradual, steady growth in institutional ownership is generally a healthy signal — not a speculative rush, but consistent conviction.
🟡

Slight buying edge — 58% buying

118 buying85 selling
Last quarter: 118 funds bought or added vs 85 that reduced or exited. It's nearly a 50/50 split — some institutions are convinced, others are taking profits. This mixed picture is normal near price highs.
📈

More new buyers each quarter (+21 vs last Q)

new funds entering per quarter
Funds opening a new ZYME position: 34 → 27 → 25 → 46. A growing influx of new institutional buyers means the asset is still gathering momentum — the consensus hasn't fully saturated yet.
🔒

46% of holders stayed for 2+ years

■ 46% conviction (2yr+) ■ 30% medium ■ 24% new
92 out of 200 hedge funds have held ZYME for over 2 years without selling. Long-term investors are generally harder to shake out during market stress, creating a stable ownership base that limits the risk of sudden capitulation.
💰

Price up while funds trimmed (+50% value, -3% shares)

Value
+49%
Shares
-2%
Last quarter: total value of institutional ZYME holdings rose +50% even though funds reduced share count by 3%. The stock price increased enough to offset the selling. Institutions are quietly trimming into price strength — watch for rotation.
📈

Growing discovery — still being found

29 → 34 → 27 → 25 → 46 new funds/Q
New funds entering each quarter: 34 → 27 → 25 → 46. A growing number of institutions are discovering ZYME each quarter. The narrative is still spreading — leaving room for ongoing capital accumulation.
🏛️

Deep conviction — 50% of holders stayed 2+ years

■ 50% veterans ■ 17% 1-2yr ■ 33% new
Of 210 current holders: 105 (50%) have held for over 2 years without selling. These are not momentum buyers — they have lived through drawdowns and stayed. A large veteran base acts as a stabilizing force during selloffs.
📋

Smaller funds dominant — 19% AUM from top-100

19% from top-100 AUM funds
37 of 200 holders rank in the top 100 by AUM, but together hold only 19% of total institutional value. The stock is held primarily by smaller and mid-sized funds.
3.8
out of 10
Low Exit Risk
Exit risk score 3.8/10 — low institutional crowding. Ownership is below peak levels, holder base is relatively sticky, and buying momentum is positive.

Methodology note: these Smart Money cards use consecutive 13F disclosure snapshots, not trade-by-trade execution data. "Buying", "selling", "new holders", and "trimmed" refer to quarter-over-quarter changes in reported holders, aggregate shares, or disclosed position values between filings. They are useful for ownership regime analysis and crowding, but they do not imply exact trade timing on the filing date.

Hedge Fund Ownership: ZYME

How many hedge funds hold ZYME — quarterly history vs. share price
Quarterly hedge fund ownership of ZYME vs. share price

Market Analysis: ZYME

Analyst Price Targets

Avg. Price Target
--

Analyst Recommendations

Stock Performance

Real-time

Company Profile: ZYME

-- --
Smart Money Signal ?
Broad Consensus, Selective Conviction

Many quality funds hold this stock, but top-tier positions remain relatively small.

41 top-rated funds 1 high-conviction
Consensus
7.0
/ 10
breadth
×
Elite
1.9
/ 10
conviction
Hedge Fund Positioning: ZYME
2026 Q1 Stats Unlock in 17 days 210 + Investors

Track Smart Money conviction in ZYME. See who's accumulating, reducing, or initiating positions.

Metric All 13F Filers (2025 Q4) Prior (2025 Q3) Change
Funds Holding 210 182 15.38%
13F Shares 72M 74M -2.91%
Total Value $1.90B $1.27B 49.78%
New Positions 48 27 +21
Increased Positions 85 65 +20
Closed Positions 22 23 -1
Reduced Positions 68 69 -1
Total Calls 6 5 20.0%
Total Puts 6 2 200.0%
PUT/CALL Ratio 1.0 0.4 Neutral

Statistics: ZYME

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Valuation Measures Data as of: --

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PEG Ratio (5yr expected) --
Price/Sales (ttm) --
Price/Book (mrq) --
Enterprise Value/Revenue --
Enterprise Value/EBITDA --
Beta (5Y Monthly) --
Short Ratio (Days to Cover) --
Short % of Float --

Financial Highlights

Profitability
Profit Margin --
Return on Assets (ttm) --
Return on Equity (ttm) --
Income Statement & Cash Flow
Revenue (ttm) --
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Total Cash (mrq) --
Total Debt/Equity (mrq) --
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Institutional Holders (2026 Q1)

210 + investors

Explore institutional interest and hedge fund ownership dynamics. Analyze portfolio weights, new positions, and conviction trends in ZYME. Verified SEC 13F-HR filings.

Top 25 institutional holders of ZYME — 2025 Q4 · Source: SEC Form 13F
# Investor % of Portfolio Shares Mkt Value
1 Capricorn Fund Managers Ltd 3.93% 1,007,210 $25.2M
2 PSP Research LLC 0.18% 10,000 $250K
3 TEMA ETFS LLC 0.18% 104,931 $2.6M
4 North Growth Management Ltd. 0.17% 46,000 $1K
5 KORNITZER CAPITAL MANAGEMENT INC /KS 0.05% 88,800 $2.2M
6 SBI Okasan Asset Management Co.Ltd. 0.03% 32,000 $775K
7 JAMES INVESTMENT RESEARCH, INC. 0.03% 10,925 $274K
8 Assenagon Asset Management S.A. 0.03% 727,986 $18.2M
9 Abacus Wealth Partners, LLC 0.03% 11,669 $292K
10 China Universal Asset Management Co., Ltd. 0.03% 13,280 $333K
11 JOURNEY STRATEGIC WEALTH LLC 0.02% 29,050 $727K
12 AlphaQuest LLC 0.01% 8,313 $219K
13 RITHOLTZ WEALTH MANAGEMENT 0.01% 24,243 $607K
14 Global Wealth Strategies & Associates 0.01% 1,635 $41K
15 Marex Group plc 0.01% 40,000 $340K
16 STRS OHIO 0.00% 30,100 $754K
17 Police & Firemen's Retirement System of New Jersey 0.00% 13,702 $343K
18 Arizona State Retirement System 0.00% 10,277 $257K
19 GAMMA Investing LLC 0.00% 1,097 $27K
20 NBC SECURITIES, INC. 0.00% 623 $16K
21 COMMONWEALTH EQUITY SERVICES, LLC 0.00% 26,031 $652K
22 KLP KAPITALFORVALTNING AS 0.00% 8,000 $200K
23 Janney Montgomery Scott LLC 0.00% 11,487 —
24 GF FUND MANAGEMENT CO. LTD. 0.00% 1,681 $42K
25 HSBC HOLDINGS PLC 0.00% 37,777 $940K
Investor Ownership
History 		% of Portfolio Prev % Rank Conviction Avg Buy Price 13F Score™ 3Y / 7Y Sell Timing Shares Mkt Value Change Change % Source Quarter Filed

Frequently Asked Questions — ZYMEWORKS INC (ZYME)

What does the Smart Money Trend signal show for ZYME?

Buying streak — 2 quarters in a row: For 2 consecutive quarters, more hedge funds added ZYME than sold it. That's a consistent pattern of professional buying — not a one-time trade. When institutions keep buying quarter after quarter, it usually means they see a multi-year opportunity, not just a short-term momentum flip.

What is the institutional breadth score for ZYME?

Slight buying edge — 58% buying: Last quarter: 118 funds bought or added vs 85 that reduced or exited. It's nearly a 50/50 split — some institutions are convinced, others are taking profits. This mixed picture is normal near price highs.

What is the fund quality score for ZYME holders?

Smaller funds dominant — 19% AUM from top-100: 37 of 200 holders rank in the top 100 by AUM, but together hold only 19% of total institutional value. The stock is held primarily by smaller and mid-sized funds.

How long have hedge funds held ZYME?

46% of holders stayed for 2+ years: 92 out of 200 hedge funds have held ZYME for over 2 years without selling. Long-term investors are generally harder to shake out during market stress, creating a stable ownership base that limits the risk of sudden capitulation.

Where does this institutional ownership data come from?

All holdings data is sourced from SEC Form 13F filings, which institutional investment managers with over $100 million in assets are required to submit quarterly. Data is parsed directly from SEC EDGAR.

Disclaimer: The information on this page is for informational purposes only and does not constitute investment advice, a recommendation, or an offer to buy or sell any security. Institutional holdings data is sourced from SEC Form 13F filings and reflects positions as of the filing date. Past performance of any fund or portfolio is not indicative of future results. 13Foresight is not a registered investment adviser. Always conduct your own due diligence before making investment decisions.