2026 Q1 Portfolio Activity
In 2026 Q1, Paradigm Biocapital Advisors LP maintained a portfolio of 40 distinct positions. The most significant new addition was INSMED INC, now representing 4.19% of the total fund value. They heavily accumulated shares in TERNS PHARMACEUTICALS INC, increasing the position by 173.5%. Conversely, Paradigm Biocapital Advisors LP completely exited their position in SPDR SERIES TRUST.
Position History
hover any row below to update
Loading…
Total Positions
40
Quarter
2026 Q1
Top Holding
ACLX (13.5%)
Top 10 Concentration
67.6%
Turnover Rate
23.4%
Sector HHI
0.18
Items per page:
Showing 1-40 of 40
Paradigm Biocapital Advisors LP Full Holdings List — 2026 Q1
| Stock | History | Sector / Type | Port % | Prev % | Rank / Prev | Conviction | Change | % Change | Influence | Shares | Mkt Value | Avg Cost | Price Held | 1st Owned | Source | Source Date | Date Reported | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
ACLX
ARCELLX INC
|
Healthcare | 13.55% | 9.53% |
#1
2
Prev: #3
|
6.5 |
—
|
50,000 | 0.9% |
P
S
|
5,774,016 | $662,972,517 |
$58.75
+95.9%
|
2022 Q4 | 13F Filing | 2026-03-31 | 2026-05-15 | ||
|
RVMD
REVOLUTION MEDI...
|
Healthcare | 13.23% | 13.51% |
#2
Prev: #2
|
6.0 |
—
|
11,300 | 0.2% |
P
S
|
6,655,703 | $647,267,117 |
$39.68
+276.1%
|
2024 Q1 | 13F Filing | 2026-03-31 | 2026-05-15 | ||
|
NUVL
NUVALENT INC
|
Healthcare | 11.15% | 13.53% |
#3
2
Prev: #1
|
5.5 |
—
|
55,000 | 1.0% |
P
S
|
5,324,433 | $545,488,161 |
$67.58
+82.4%
|
2023 Q2 | 13F Filing | 2026-03-31 | 2026-05-15 | ||
|
PCVX
VAXCYTE INC
|
Healthcare | 5.69% | 4.79% |
#4
4
Prev: #8
|
4.8 |
—
|
725,000 | 17.8% |
P
S
|
4,793,020 | $278,522,392 | 2024 Q1 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
EWTX
EDGEWISE THERAP...
|
Healthcare | 4.74% | 4.14% |
#5
6
Prev: #11
|
4.4 |
—
|
823,828 | 12.6% |
P
S
|
7,365,038 | $231,998,697 | 2024 Q1 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
GMAB
GENMAB A/S
|
Healthcare | 4.37% | 5.53% |
#6
2
Prev: #4
|
3.7 |
—
|
928,002 | 13.2% |
P
S
|
7,967,836 | $213,777,040 | 2025 Q3 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
INSM
INSMED INC
|
Healthcare | 4.19% | — |
#7
Prev: #—
|
5.2 |
—
|
1,254,488 | — |
NEW
|
1,254,488 | $205,133,878 | 2021 Q4 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
TARS
TARSUS PHARMACE...
|
Healthcare | 3.67% | 5.35% |
#8
3
Prev: #5
|
2.5 |
—
|
no change | no change |
P
S
|
2,562,154 | $179,735,103 | 2023 Q4 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
BLTE
BELITE BIO INC
|
Healthcare | 3.63% | — |
#9
Prev: #—
|
5.0 |
—
|
1,114,784 | — |
NEW
|
1,114,784 | $177,741,161 | 2026 Q1 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
ERAS
ERASCA INC
|
Healthcare | 3.44% | 1.34% |
#10
7
Prev: #17
|
1.4 |
—
|
-3,766,393 | -26.6% |
P
S
|
10,392,702 | $168,153,918 | 2024 Q2 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
CNTA
CENTESSA PHARMA...
|
Healthcare | 2.90% | — |
#11
Prev: #—
|
4.7 |
—
|
3,574,048 | — |
NEW
|
3,574,048 | $141,961,187 | 2026 Q1 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
OLMA
OLEMA PHARMACEU...
|
Healthcare | 2.44% | 4.81% |
#12
5
Prev: #7
|
3.0 |
—
|
476,404 | 6.3% |
P
S
|
8,020,576 | $119,586,788 | 2023 Q1 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
TERN
TERNS PHARMACEU...
|
Healthcare | 2.39% | 0.84% |
#13
11
Prev: #24
|
4.0 |
—
|
1,406,213 | 173.5% |
P
S
|
2,216,499 | $116,853,827 | 2025 Q4 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
ORKA
ORUKA THERAPEUT...
|
Healthcare | 2.33% | 1.32% |
#14
5
Prev: #19
|
3.4 |
—
|
610,000 | 35.7% |
P
S
|
2,320,316 | $113,811,500 | 2024 Q3 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
APGE
APOGEE THERAPEU...
|
Healthcare | 2.32% | 2.16% |
#15
Prev: #15
|
3.4 |
—
|
225,000 | 20.0% |
P
S
|
1,348,243 | $113,481,613 | 2024 Q1 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
SYRE
SPYRE THERAPEUT...
|
Healthcare | 2.02% | 1.23% |
#16
4
Prev: #20
|
3.3 |
—
|
490,000 | 33.4% |
P
S
|
1,957,266 | $98,724,497 | 2024 Q3 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
CYTK
CYTOKINETICS IN...
|
Healthcare | 1.99% | — |
#17
Prev: #—
|
4.3 |
—
|
1,480,857 | — |
NEW
|
1,480,857 | $97,603,285 | 2025 Q1 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
ABVX
ABIVAX SA
|
Healthcare | 1.76% | 4.88% |
#18
12
Prev: #6
|
0.7 |
—
|
-645,000 | -45.5% |
P
S
|
772,473 | $86,014,869 | 2025 Q3 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
TNGX
TANGO THERAPEUT...
|
Healthcare | 1.71% | — |
#19
Prev: #—
|
4.2 |
—
|
4,009,679 | — |
NEW
|
4,009,679 | $83,882,485 | 2025 Q3 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
MAZE
MAZE THERAPEUTI...
|
Healthcare | 1.67% | — |
#20
Prev: #—
|
4.2 |
—
|
2,744,399 | — |
NEW
|
2,744,399 | $81,920,310 | 2026 Q1 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
TYRA
TYRA BIOSCIENCE...
|
Healthcare | 1.61% | — |
#21
Prev: #—
|
4.1 |
—
|
2,054,991 | — |
NEW
|
2,054,991 | $78,706,155 | 2026 Q1 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
VRDN
VIRIDIAN THERAP...
|
Healthcare | 1.26% | 1.15% |
#22
Prev: #22
|
3.5 |
—
|
1,705,791 | 118.2% |
P
S
|
3,148,893 | $61,592,347 | 2021 Q4 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
SRRK
SCHOLAR ROCK HL...
|
Healthcare | 1.23% | 3.44% |
#23
11
Prev: #12
|
0.5 |
—
|
-1,836,077 | -60.0% |
P
S
|
1,226,080 | $60,274,093 | 2024 Q4 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
MIRM
MIRUM PHARMACEU...
|
Healthcare | 1.18% | — |
#24
Prev: #—
|
4.0 |
—
|
625,000 | — |
NEW
|
625,000 | $57,737,500 | 2026 Q1 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
EYPT
EYEPOINT INC
|
Healthcare | 0.83% | 1.72% |
#25
9
Prev: #16
|
0.8 |
—
|
-549,038 | -14.9% |
P
S
|
3,142,437 | $40,506,013 | 2025 Q3 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
LXEO
LEXEO THERAPEUT...
|
Healthcare | 0.73% | 1.21% |
#26
5
Prev: #21
|
2.8 |
—
|
1,420,936 | 29.8% |
P
S
|
6,184,134 | $35,496,929 | 2025 Q4 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
N/A
VERADERMICS INC
|
|
Unknown | 0.68% | — |
#27
Prev: #—
|
3.8 |
—
|
525,000 | — |
NEW
|
525,000 | $33,153,750 | — | 13F Filing | 2026-03-31 | 2026-05-15 | ||
|
VOR
VOR BIOPHARMA I...
|
Healthcare | 0.64% | 0.58% |
#28
2
Prev: #26
|
1.3 |
—
|
no change | no change |
P
S
|
1,750,000 | $31,220,000 | 2021 Q4 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
URGN
UROGEN PHARMA L...
|
Healthcare | 0.63% | 2.67% |
#29
16
Prev: #13
|
0.3 |
—
|
-2,769,699 | -61.9% |
P
S
|
1,703,949 | $30,637,003 | 2025 Q3 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
GPCR
STRUCTURE THERA...
|
Healthcare | 0.54% | — |
#30
Prev: #—
|
3.7 |
—
|
545,287 | — |
NEW
|
545,287 | $26,282,833 | 2025 Q3 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
IVA
INVENTIVA SA
|
Healthcare | 0.45% | 0.47% |
#31
2
Prev: #29
|
1.2 |
—
|
no change | no change |
P
S
|
4,000,000 | $22,200,000 | 2025 Q4 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
ORIC
ORIC PHARMACEUT...
|
Healthcare | 0.44% | 0.50% |
#32
4
Prev: #28
|
0.2 |
—
|
-700,000 | -29.2% |
P
S
|
1,701,217 | $21,554,419 | 2025 Q4 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
ASMB
ASSEMBLY BIOSCI...
|
Healthcare | 0.38% | 0.58% |
#33
6
Prev: #27
|
1.2 |
—
|
no change | no change |
P
S
|
665,251 | $18,460,715 | 2025 Q4 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
BBOT
BRIDGEBIO ONCOL...
|
Healthcare | 0.16% | 0.72% |
#34
9
Prev: #25
|
0.1 |
—
|
-1,393,536 | -61.6% |
P
S
|
868,213 | $7,770,506 | 2025 Q3 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
KLRS
KALARIS THERAPE...
|
Healthcare | 0.08% | 0.15% |
#35
5
Prev: #30
|
1.0 |
—
|
no change | no change |
P
S
|
700,000 | $4,039,000 | 2025 Q4 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
OCUL
OCULAR THERAPEU...
|
Healthcare | 0.00% | 0.91% |
Sold All 😨
(Was: #23) |
0.0 |
—
|
-2,935,284 | -100.0% |
CLOSED
|
— | $— | 2025 Q1 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
BBIO
BRIDGEBIO PHARM...
|
Healthcare | 0.00% | 1.34% |
Sold All 😨
(Was: #18) |
0.0 |
—
|
-684,277 | -100.0% |
CLOSED
|
— | $— | 2024 Q2 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
CRNX
CRINETICS PHARM...
|
Healthcare | 0.00% | 2.63% |
Sold All 😨
(Was: #14) |
0.0 |
—
|
-2,210,774 | -100.0% |
CLOSED
|
— | $— | 2022 Q3 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
CDTX
CIDARA THERAPEU...
|
Unknown | 0.00% | 4.28% |
Sold All 😨
(Was: #10) |
0.0 |
—
|
-759,565 | -100.0% |
CLOSED
|
— | $— | 2025 Q3 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
XBI
PUT
SPDR SERIES TRU...
|
PUT Option | 0.00% | 4.67% |
Sold All 😨
(Was: #9) |
0.0 |
—
|
-1,500,000 | -100.0% |
CLOSED
|
— | $— | 2025 Q3 | 13F Filing | 2026-03-31 | 2026-05-15 |
Showing 1-40 of 40 holdings