ORBIMED ADVISORS LLC

All Holdings — 2025 Q4

Portfolio Concentration Analytics: 7.6
Risk-based ENB:
Total Positions
133
Quarter
2025 Q4
Top Holding
EWTX (7.9%)
Top 10 Concentration
40.4%
Turnover Rate
23.4%
Sector HHI
0.18
Items per page:
1-25 of 133
Stock History Sector / Type Port % Prev % Rank / Prev Conviction Change % Change Influence Shares Mkt Value Avg Cost Price Held 1st Owned Source Source Date Date Reported
EWTX
EDGEWISE THERAP...
Healthcare 7.86% 5.92% #1
Prev: #1
3.1 no change no change
P
S
15,518,492 $385,091,379 2021 Q1 13F Filing 2025-12-31 2026-02-14 (Est.)
LLY
ELI LILLY & CO
Healthcare 6.61% 5.40% #2 1
Prev: #3
2.6 no change no change
P
S
301,200 $323,693,616 2001 Q2 13F Filing 2025-12-31 2026-02-14 (Est.)
BSX
BOSTON SCIENTIF...
Healthcare 4.71% 5.57% #3 1
Prev: #2
1.9 -10,000 -0.4%
P
S
2,419,300 $230,680,255 2006 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
SVA
SINOVAC BIOTECH...
Unknown 3.77% 4.33% #4
Prev: #4
1.5 no change no change
P
S
2,718,735 $184,466,170 2011 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
EW
EDWARDS LIFESCI...
Healthcare 3.21% 3.08% #5 3
Prev: #8
3.3 158,900 9.4%
P
S
1,842,900 $157,107,225 2011 Q1 13F Filing 2025-12-31 2026-02-14 (Est.)
UPB
UPSTREAM BIO IN...
Healthcare 3.16% 2.52% #6 6
Prev: #12
1.3 no change no change
P
S
5,693,589 $154,580,941 2024 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
ISRG
INTUITIVE SURGI...
Healthcare 3.04% 3.02% #7 2
Prev: #9
1.2 -23,800 -8.3%
P
S
263,400 $149,179,224 2010 Q2 13F Filing 2025-12-31 2026-02-14 (Est.)
SION
SIONNA THERAPEU...
Healthcare 2.99% 2.56% #8 3
Prev: #11
1.2 -143,304 -3.9%
P
S
3,561,655 $146,526,487 2025 Q1 13F Filing 2025-12-31 2026-02-14 (Est.)
MBX
MBX BIOSCIENCES...
Healthcare 2.53% 1.65% #9 8
Prev: #17
1.0 -67,684 -1.7%
P
S
3,935,203 $124,116,303 2024 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
ARGX
ARGENX SE
Healthcare 2.51% 2.99% #10
Prev: #10
1.0 -26,300 -15.3%
P
S
146,000 $122,778,700 2017 Q2 13F Filing 2025-12-31 2026-02-14 (Est.)
ELVN
ENLIVEN THERAPE...
Healthcare 2.50% 3.83% #11 6
Prev: #5
1.0 no change no change
P
S
7,959,538 $122,576,885 2023 Q1 13F Filing 2025-12-31 2026-02-14 (Est.)
ALNY
ALNYLAM PHARMAC...
Healthcare 2.34% 3.23% #12 6
Prev: #6
1.0 -12,800 -4.2%
P
S
288,800 $114,841,320 2010 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
SYK
STRYKER CORPORA...
Healthcare 2.33% 3.12% #13 6
Prev: #7
1.0 -34,200 -9.5%
P
S
325,000 $114,227,750 2006 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
SPRY
ARS PHARMACEUTI...
Healthcare 1.97% 1.96% #14 1
Prev: #15
0.8 no change no change
P
S
8,288,510 $96,561,142 2020 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
TERN
TERNS PHARMACEU...
Healthcare 1.78% 1.33% #15 6
Prev: #21
0.9 -5,409,671 -71.5%
P
S
2,153,300 $86,993,320 2021 Q1 13F Filing 2025-12-31 2026-02-14 (Est.)
IRON
DISC MEDICINE I...
Healthcare 1.73% 2.20% #16 3
Prev: #13
0.8 -347,470 -24.6%
P
S
1,067,550 $84,774,146 2022 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
CAI
CARIS LIFE SCIE...
Healthcare 1.72% 2.16% #17 3
Prev: #14
2.7 81,153 2.7%
P
S
3,116,011 $84,069,977 2025 Q2 13F Filing 2025-12-31 2026-02-14 (Est.)
NTRA
NATERA INC
Healthcare 1.71% 1.62% #18 1
Prev: #19
0.7 -63,500 -14.8%
P
S
365,800 $83,801,122 2015 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
CMPX
COMPASS THERAPE...
Healthcare 1.67% 1.25% #19 6
Prev: #25
0.7 no change no change
P
S
15,219,994 $81,731,368 2021 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
GPCR
STRUCTURE THERA...
Healthcare 1.65% 0.75% #20 20
Prev: #40
2.7 22,503 2.0%
P
S
1,161,803 $80,803,399 2024 Q2 13F Filing 2025-12-31 2026-02-14 (Est.)
DHR
DANAHER CORPORA...
Healthcare 1.40% 1.23% #21 7
Prev: #28
2.6 36,700 13.9%
P
S
299,800 $68,630,216 2019 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
CGON
CG ONCOLOGY INC
Healthcare 1.29% 1.63% #22 4
Prev: #18
0.6 -210,300 -12.2%
P
S
1,516,550 $62,967,156 2024 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
APLS
APELLIS PHARMAC...
Healthcare 1.25% 1.24% #23 4
Prev: #27
2.5 106,500 4.6%
P
S
2,429,868 $61,038,284 2018 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
AVBP
ARRIVENT BIOPHA...
Healthcare 1.24% 1.31% #24 2
Prev: #22
0.5 no change no change
P
S
3,027,328 $60,909,839 2024 Q1 13F Filing 2025-12-31 2026-02-14 (Est.)
CI
THE CIGNA GROUP
Healthcare 1.15% 1.10% #25 6
Prev: #31
2.5 42,200 25.9%
P
S
205,000 $56,422,150 2009 Q2 13F Filing 2025-12-31 2026-02-14 (Est.)
SIBN
SI-BONE INC
Healthcare 0.00% 0.89%
Sold All 😨
(Was: #37)
0.3 -2,578,979 -100.0%
CLOSED
$— 2018 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
SCPH
SCPHARMACEUTICA...
Unknown 0.00% 0.81%
Sold All 😨
(Was: #38)
0.3 -6,059,528 -100.0%
CLOSED
$— 2017 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
ITGR
INTEGER HLDGS C...
Healthcare 0.00% 0.70%
Sold All 😨
(Was: #42)
0.3 -290,000 -100.0%
CLOSED
$— 2024 Q2 13F Filing 2025-12-31 2026-02-14 (Est.)
AKRO
AKERO THERAPEUT...
Healthcare 0.00% 0.59%
Sold All 😨
(Was: #49)
0.3 -526,200 -100.0%
CLOSED
$— 2023 Q2 13F Filing 2025-12-31 2026-02-14 (Est.)
ABT
ABBOTT LABS
CALL
CALL Option 0.00% 0.47%
Sold All 😨
(Was: #53)
0.3 -150,000 -100.0%
CLOSED
$— 2007 Q2 13F Filing 2025-12-31 2026-02-14 (Est.)
BSX
BOSTON SCIENTIF...
CALL
CALL Option 0.00% 0.46%
Sold All 😨
(Was: #54)
0.3 -200,000 -100.0%
CLOSED
$— 2006 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
PFE
PFIZER INC
CALL
CALL Option 0.00% 0.30%
Sold All 😨
(Was: #67)
0.3 -500,000 -100.0%
CLOSED
$— 2001 Q2 13F Filing 2025-12-31 2026-02-14 (Est.)
AZN
ASTRAZENECA PLC
CALL
CALL Option 0.00% 0.27%
Sold All 😨
(Was: #71)
0.3 -150,000 -100.0%
CLOSED
$— 2014 Q1 13F Filing 2025-12-31 2026-02-14 (Est.)
AMLX
AMYLYX PHARMACE...
Healthcare 0.00% 0.24%
Sold All 😨
(Was: #74)
0.3 -750,600 -100.0%
CLOSED
$— 2023 Q1 13F Filing 2025-12-31 2026-02-14 (Est.)
VSTM
VERASTEM INC
Healthcare 0.00% 0.18%
Sold All 😨
(Was: #78)
0.3 -887,561 -100.0%
CLOSED
$— 2023 Q2 13F Filing 2025-12-31 2026-02-14 (Est.)
MIST
MILESTONE PHARM...
Healthcare 0.00% 0.15%
Sold All 😨
(Was: #82)
0.3 -3,221,828 -100.0%
CLOSED
$— 2019 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
APLS
APELLIS PHARMAC...
CALL
CALL Option 0.00% 0.13%
Sold All 😨
(Was: #84)
0.3 -250,000 -100.0%
CLOSED
$— 2018 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
BTSG
BRIGHTSPRING HE...
CALL
CALL Option 0.00% 0.10%
Sold All 😨
(Was: #89)
0.3 -150,000 -100.0%
CLOSED
$— 2025 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
CRNX
CRINETICS PHARM...
PUT
PUT Option 0.00% 0.10%
Sold All 😨
(Was: #91)
0.3 -100,000 -100.0%
CLOSED
$— 2018 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
IMTX
IMMATICS N.V
Healthcare 0.00% 0.09%
Sold All 😨
(Was: #93)
0.3 -466,601 -100.0%
CLOSED
$— 2023 Q1 13F Filing 2025-12-31 2026-02-14 (Est.)
SRRK
SCHOLAR ROCK HL...
CALL
CALL Option 0.00% 0.09%
Sold All 😨
(Was: #94)
0.3 -100,000 -100.0%
CLOSED
$— 2022 Q2 13F Filing 2025-12-31 2026-02-14 (Est.)
TGTX
TG THERAPEUTICS...
CALL
CALL Option 0.00% 0.08%
Sold All 😨
(Was: #95)
0.3 -100,000 -100.0%
CLOSED
$— 2023 Q2 13F Filing 2025-12-31 2026-02-14 (Est.)
N/A
CELCUITY INC
Bond/Debt 0.00% 0.06%
Sold All 😨
(Was: #97)
0.3 -2,000,000 -100.0%
CLOSED
$— 13F Filing 2025-12-31 2026-02-14 (Est.)
ATAI
ATAI LIFE SCIEN...
Healthcare 0.00% 0.04%
Sold All 😨
(Was: #99)
0.3 -347,000 -100.0%
CLOSED
$— 2025 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
KRRO
KORRO BIO INC
Healthcare 0.00% 0.04%
Sold All 😨
(Was: #100)
0.3 -32,400 -100.0%
CLOSED
$— 2024 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
MURA
MURAL ONCOLOGY ...
Healthcare 0.00% 0.03%
Sold All 😨
(Was: #101)
0.3 -588,800 -100.0%
CLOSED
$— 2025 Q2 13F Filing 2025-12-31 2026-02-14 (Est.)
LYEL
LYELL IMMUNOPHA...
Healthcare 0.00% 0.02%
Sold All 😨
(Was: #104)
0.3 -51,727 -100.0%
CLOSED
$— 2024 Q1 13F Filing 2025-12-31 2026-02-14 (Est.)
KZR
KEZAR LIFE SCIE...
Healthcare 0.00% 0.02%
Sold All 😨
(Was: #105)
0.3 -192,700 -100.0%
CLOSED
$— 2021 Q2 13F Filing 2025-12-31 2026-02-14 (Est.)
XERS
XERIS BIOPHARMA...
Healthcare 0.00% 0.02%
Sold All 😨
(Was: #106)
0.3 -80,420 -100.0%
CLOSED
$— 2024 Q1 13F Filing 2025-12-31 2026-02-14 (Est.)
PASG
PASSAGE BIO INC
Healthcare 0.00% 0.01%
Sold All 😨
(Was: #107)
0.3 -59,046 -100.0%
CLOSED
$— 2020 Q1 13F Filing 2025-12-31 2026-02-14 (Est.)
DHAI
DIH HLDG US INC
Healthcare 0.00% 0.01%
Sold All 😨
(Was: #108)
0.3 -1,915,000 -100.0%
CLOSED
$— 2025 Q1 13F Filing 2025-12-31 2026-02-14 (Est.)
Showing 1-25 of 133 holdings

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