Stock Analysis
Data Source: SEC EDGAR 13F
Updated Hourly

Upstream Bio Inc (UPB)

136 + Investors. Track Smart Money conviction in UPB. See who's accumulating, reducing, or initiating positions.

Current Price
-- USD
Analyst Target
-- (0 analysts)
Upside
0.00%
Net Flow Q/Q
↑ +6
Streak
6Q ▲
Buyers last Q
55%

Smart Money Signals — UPB

Based on 138 hedge funds · latest filing: 2026 Q1 · updated quarterly

📈

Buying streak — 6 quarters in a row

last 6Q
For 6 consecutive quarters, more hedge funds added UPB than sold it. That's a consistent pattern of professional buying — not a one-time trade. When institutions keep buying quarter after quarter, it usually means they see a multi-year opportunity, not just a short-term momentum flip.
🏔️

At the ownership peak (100% of max)

100% of all-time peak
138 hedge funds hold UPB right now — the highest count in 3.0 years. When ownership is this concentrated, any bad news can trigger a chain reaction: one big fund sells, others follow. This is a classic 'crowded trade' — high popularity doesn't equal safety.
🚀

Fast accumulation — +77% more funds vs a year ago

fund count last 6Q
+60 new funds entered over the past year (+77% YoY). That's a rapid rush of institutional money. Fast accumulation often signals a major thesis — but it also means the stock could fall quickly if that thesis breaks.
🟡

Slight buying edge — 55% buying

93 buying75 selling
Last quarter: 93 funds bought or added vs 75 that reduced or exited. It's nearly a 50/50 split — some institutions are convinced, others are taking profits. This mixed picture is normal near price highs.
➡️

Steady new buyers — ~46 new funds per quarter

new funds entering per quarter
Funds opening this position for the first time: 14 → 25 → 46 → 46. A stable flow of new institutional buyers suggests ongoing interest without signs of either acceleration or slowdown.
🔄

Mostly new holders — 50% entered in last year

■ 3% conviction (2yr+) ■ 47% medium ■ 50% new
Only 4 funds (3%) have held >2 years. The majority of current holders are relatively new to the position. New holders tend to sell faster when prices drop — a shallow conviction base that could amplify any sell-off.
💎

Buying through price weakness — shares -13%, value -71%

Value
-71%
Shares
-13%
Last quarter: funds added -13% more shares while total portfolio value only changed -71%. Institutions were buying while the price was falling — a high-conviction accumulation signal. They're deliberately loading up on the dip.
🚀

Acceleration phase — new buyers rushing in

26 → 14 → 25 → 46 → 46 new funds/Q
New funds entering each quarter: 14 → 25 → 46 → 46. The pace of institutional discovery is accelerating sharply. This is the 'hot idea' phase — the thesis is being passed from fund to fund. You are not late — the accumulation wave is still building.
🌱

Early stage — 65% of holders entered in last year

■ 6% veterans ■ 29% 1-2yr ■ 65% new
Of 142 current holders: 93 (65%) entered in the past year, only 8 (6%) are 2+ year veterans. This is an early-phase institutional idea — still being discovered. High upside potential if the thesis plays out, but thin conviction base.
✅

Strong quality — 35% AUM from major funds

35% from top-100 AUM funds
35 of 136 holders rank in the top 100 by AUM, accounting for 35% of total institutional value held. A meaningful share of the ownership value comes from the most well-resourced institutions.
5.4
out of 10
Moderate Exit Risk
Exit risk score 5.4/10 — some crowding factors present, but no critical concentration. Watch ownership trend over the next 1–2 quarters for direction.

Methodology note: these Smart Money cards use consecutive 13F disclosure snapshots, not trade-by-trade execution data. "Buying", "selling", "new holders", and "trimmed" refer to quarter-over-quarter changes in reported holders, aggregate shares, or disclosed position values between filings. They are useful for ownership regime analysis and crowding, but they do not imply exact trade timing on the filing date.

Institutional Sentiment Summary — UPB

In 2026 Q1, 93 hedge funds were net buyers of UPB (46 opened a new position, 47 added to an existing one), while 75 reduced or exited (35 trimmed, 40 sold completely) — a 55% buyer ratio, indicating a slight buying edge. This marks 6 consecutive quarters of net institutional buying — a persistent conviction signal. 35% of total institutional value in UPB is held by top-100 AUM funds, reflecting strong institutional quality. Net fund flow last quarter: +6 funds (more new holders than closures). Total institutional holders: 138.

Hedge Fund Ownership: UPB

How many hedge funds hold UPB — quarterly history vs. share price
Quarterly hedge fund ownership of UPB vs. share price

Market Analysis: UPB

Analyst Price Targets

Avg. Price Target
--

Analyst Recommendations

Stock Performance

Real-time

Company Profile: UPB

-- --

Institutional ownership data sourced from SEC EDGAR Form 13F-HR filings.

Is It Too Late to Buy Upstream Bio Inc (UPB) Based on Hedge Fund 13F Filings?

Signal Freshness measures how much UPB has moved relative to its sector benchmark (XLV) since the 2026 Q1 13F filing. A stock that has barely outrun its sector is still a relatively fresh entry point — the fund's thesis has not yet been priced in by the broader market.

Since Quarter End March 31, 2026 · 86d ago
UPB
-28.9%
XLV
+6.8%

UPB outperformed XLV by -35.7% since March 31, 2026.

Since 13F Filing Date May 15, 2026 · 41d ago
UPB
-29.6%
XLV
+7.9%

Since the filing became public, UPB outperformed XLV by -37.5% .

Interpretation: The stock is tracking its sector benchmark closely. The signal remains fresh and the entry point is still near the fund's implied reference. Learn more →

Smart Money Signal ?
Limited Smart Money Interest

No strong consensus or elite conviction detected among institutional holders.

16 top-rated funds 2 high-conviction
Consensus
5.3
/ 10
breadth
×
Elite
2.3
/ 10
conviction
Hedge Fund Positioning: UPB
136 + Investors

Track Smart Money conviction in UPB. See who's accumulating, reducing, or initiating positions.

Metric All 13F Filers (2026 Q1) Prior (2025 Q4) Change
Funds Holding 136 132 3.03%
13F Shares 45M 51M -13.07%
Total Value $401M $1.39B -71.17%
New Positions 44 46 -2
Increased Positions 46 41 +5
Closed Positions 40 10 +30
Reduced Positions 35 34 +1
Total Calls 3 2 50.0%
Total Puts 3 2 50.0%
PUT/CALL Ratio 1.0 1.0 Neutral

Statistics: UPB

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Valuation Measures Data as of: --

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PEG Ratio (5yr expected) --
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Price/Book (mrq) --
Enterprise Value/Revenue --
Enterprise Value/EBITDA --
Beta (5Y Monthly) --
Short Ratio (Days to Cover) --
Short % of Float --

Financial Highlights

Profitability
Profit Margin --
Return on Assets (ttm) --
Return on Equity (ttm) --
Income Statement & Cash Flow
Revenue (ttm) --
Net Income Avi to Common (ttm) --
Diluted EPS (ttm) --
Total Cash (mrq) --
Total Debt/Equity (mrq) --
Levered Free Cash Flow (ttm) --

Institutional Holders (2026 Q1)

136 + investors

Explore institutional interest and hedge fund ownership dynamics. Analyze portfolio weights, new positions, and conviction trends in UPB. Verified SEC 13F-HR filings.

QUARTER:
Top 25 UPB holders by conviction (% of portfolio weight) — 2026 Q1 · Source: SEC Form 13F
# Investor % of Portfolio Shares Mkt Value
1 Enavate Sciences GP, LLC 6.30% 2,459,703 $22.1M
2 Decheng Capital LLC 3.71% 2,724,868 $24.5M
3 Propel Bio Management, LLC 1.95% 341,779 $3.1M
4 Orbimed Advisors LLC 1.02% 5,693,589 $51.2M
5 Parkman Healthcare Partners LLC 0.73% 786,783 $7.1M
6 Bain Capital Life Sciences Investors, LLC 0.70% 867,211 $7.8M
7 Samsara BioCapital, LLC 0.64% 736,047 $6.6M
8 Sphera Funds Management LTD. 0.51% 358,000 $3.2M
9 Prosight Management, LP 0.36% 241,123 $2.2M
10 EntryPoint Capital, LLC 0.19% 73,568 $662K
11 Boxer Capital Management, LLC 0.18% 150,000 $1.4M
12 Y-Intercept (Hong Kong) Ltd 0.17% 1,000,631 $9.0M
13 Nantahala Capital Management, LLC 0.13% 400,000 $3.6M
14 Stonepine Capital Management, LLC 0.13% 35,000 $315K
15 Altshuler Shaham Ltd 0.06% 380,061 $3.4M
16 TCG Crossover Management, LLC 0.05% 181,063 $1.6M
17 Jump Financial, LLC 0.04% 319,400 $2.9M
18 SEB Asset Management AB 0.03% 878,473 $7.9M
19 Diadema Partners LP 0.03% 21,609 $194K
20 XTX Topco Ltd 0.03% 209,277 $1.9M
21 Axq Capital, LP 0.03% 27,503 $248K
22 Woodline Partners LP 0.03% 831,481 $7.5M
23 Virtus Investment Advisers, LLC 0.02% 10,046 $90K
24 ADAR1 Capital Management, LLC 0.02% 35,000 $315K
25 Persistent Asset Partners Ltd 0.02% 5,495 $49K
Investor Ownership
History 		% of Portfolio Prev % Rank Conviction Avg Buy Price 13F Score™ 3Y / 7Y Sell Timing Shares Mkt Value Change Change % Source Quarter Filed

Frequently Asked Questions — Upstream Bio Inc (UPB)

What does the Smart Money Trend signal show for UPB?

Buying streak — 6 quarters in a row: For 6 consecutive quarters, more hedge funds added UPB than sold it. That's a consistent pattern of professional buying — not a one-time trade. When institutions keep buying quarter after quarter, it usually means they see a multi-year opportunity, not just a short-term momentum flip.

What is the institutional breadth score for UPB?

Slight buying edge — 55% buying: Last quarter: 93 funds bought or added vs 75 that reduced or exited. It's nearly a 50/50 split — some institutions are convinced, others are taking profits. This mixed picture is normal near price highs.

What is the fund quality score for UPB holders?

Strong quality — 35% AUM from major funds: 35 of 136 holders rank in the top 100 by AUM, accounting for 35% of total institutional value held. A meaningful share of the ownership value comes from the most well-resourced institutions.

How long have hedge funds held UPB?

Mostly new holders — 50% entered in last year: Only 4 funds (3%) have held >2 years. The majority of current holders are relatively new to the position. New holders tend to sell faster when prices drop — a shallow conviction base that could amplify any sell-off.

Is it too late to buy Upstream Bio Inc (UPB) following the 2026 Q1 hedge fund 13F filings?

As of today, UPB has moved -29.6% since the 2026 Q1 13F filing date (May 15, 2026), compared to +7.9% for the XLV sector ETF — an outperformance of -37.5%. Since the quarter end (March 31, 2026), UPB has gained -28.9% vs +6.8% for XLV. The stock is tracking its sector benchmark closely. The signal remains fresh and the entry point is still near the fund's implied reference.

Where does this institutional ownership data come from?

All holdings data is sourced from SEC Form 13F filings, which institutional investment managers with over $100 million in assets are required to submit quarterly. Data is parsed directly from SEC EDGAR.

Disclaimer: The information on this page is for informational purposes only and does not constitute investment advice, a recommendation, or an offer to buy or sell any security. Institutional holdings data is sourced from SEC Form 13F filings and reflects positions as of the filing date. Past performance of any fund or portfolio is not indicative of future results. 13Foresight is not a registered investment adviser. Always conduct your own due diligence before making investment decisions.

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