Upstream Bio Inc (UPB) Hedge Fund Ownership (Q2 2026)

Upstream Bio Inc (UPB)

144 + Investors. Track Smart Money conviction in UPB. See who's accumulating, reducing, or initiating positions.

Smart Money Signals — UPB

Based on 146 hedge funds · latest filing: 2026 Q2 · updated quarterly

📈

Buying streak — 7 quarters in a row

last 6Q

For 7 consecutive quarters, more hedge funds added UPB than sold it. That's a consistent pattern of professional buying — not a one-time trade. When institutions keep buying quarter after quarter, it usually means they see a multi-year opportunity, not just a short-term momentum flip.

🏔️

At the ownership peak (100% of max)

100% of all-time peak

146 hedge funds hold UPB right now — the highest count in 3.0 years. When ownership is this concentrated, any bad news can trigger a chain reaction: one big fund sells, others follow. This is a classic 'crowded trade' — high popularity doesn't equal safety.

🚀

Fast accumulation — +78% more funds vs a year ago

fund count last 6Q

+64 new funds entered over the past year (+78% YoY). That's a rapid rush of institutional money. Fast accumulation often signals a major thesis — but it also means the stock could fall quickly if that thesis breaks.

🟢

More buyers than sellers — 63% buying

102 buying59 selling

Last quarter: 102 funds were net buyers (37 opened a brand new position + 65 added to an existing one). Only 59 were sellers (29 trimmed + 30 sold completely). A clear majority buying is a strong confirmation signal.

⚠️

Fewer new buyers each quarter (-9 vs last Q)

new funds entering per quarter

Funds opening this position for the first time: 26 → 46 → 46 → 37. Each quarter fewer new institutions are entering. This usually means most funds that wanted in are already in — the stock is well-known but the pool of potential new buyers is shrinking.

🔄

Mostly new holders — 50% entered in last year

■ 4% conviction (2yr+) ■ 46% medium ■ 50% new

Only 6 funds (4%) have held >2 years. The majority of current holders are relatively new to the position. New holders tend to sell faster when prices drop — a shallow conviction base that could amplify any sell-off.

💎

Buying through price weakness — shares +10%, value -15%

Value

-15%

+10%

Last quarter: funds added +10% more shares while total portfolio value only changed -15%. Institutions were buying while the price was falling — a high-conviction accumulation signal. They're deliberately loading up on the dip.

📈

Growing discovery — still being found

14 → 26 → 46 → 46 → 37 new funds/Q

New funds entering each quarter: 26 → 46 → 46 → 37. A growing number of institutions are discovering UPB each quarter. The narrative is still spreading — leaving room for ongoing capital accumulation.

📊

Mixed cohorts — 6% veterans, 54% new entrants

■ 6% veterans ■ 39% 1-2yr ■ 54% new

Of 147 current holders: 9 (6%) held 2+ years, 58 held 1–2 years, 80 (54%) entered in the past year. Balanced distribution — some institutional memory, some recent momentum buyers.

🏆

Elite ownership — 51% AUM from top-100 funds

51% from top-100 AUM funds

42 of 144 holders are among the 100 largest funds by AUM, controlling 51% of total institutional value in UPB. When the biggest players dominate the cap table, it signifies deep institutional support — since mega-funds deploy the most rigorous due diligence and capital.

5.0

out of 10

Moderate Exit Risk

Exit risk score 5.0/10 — some crowding factors present, but no critical concentration. Watch ownership trend over the next 1–2 quarters for direction.

Methodology note: these Smart Money cards use consecutive 13F disclosure snapshots, not trade-by-trade execution data. "Buying", "selling", "new holders", and "trimmed" refer to quarter-over-quarter changes in reported holders, aggregate shares, or disclosed position values between filings. They are useful for ownership regime analysis and crowding, but they do not imply exact trade timing on the filing date.

Metric	All 13F Filers (2026 Q2)	Prior (2026 Q1)	Change
Funds Holding	144	139	3.6%
13F Shares	50M	46M	10.28%
Total Value	$346M	$407M	-15.1%
New Positions	37	46	-9
Increased Positions	65	46	+19
Closed Positions	30	40	-10
Reduced Positions	28	36	-8
Total Calls	3	3	-
Total Puts	0	3	-100.0%
PUT/CALL Ratio	0.0	1.0	Bullish

Metric

All 13F Filers (2026 Q2)

Prior (2026 Q1)

Change

Funds Holding

144

139

3.6%

13F Shares

50M

46M

10.28%

Total Value

$346M

$407M

-15.1%

New Positions

-9

Increased Positions

+19

Closed Positions

-10

Reduced Positions

-8

Total Calls

Total Puts

-100.0%

PUT/CALL Ratio

0.0

1.0

Bullish

Institutional Holders (2026 Q2)

144 + investors

Explore institutional interest and hedge fund ownership dynamics. Analyze portfolio weights, new positions, and conviction trends in UPB. Verified SEC 13F-HR filings.

QUARTER:

FILTER:All New Added To Reduced No Change | Overweight >5%

Top 25 UPB holders by conviction (% of portfolio weight) — 2026 Q2 · Source: SEC Form 13F
#	Investor	% of Portfolio	Shares	Mkt Value
1	Enavate Sciences GP, LLC	4.93%	2,459,703	$17.0M
2	Decheng Capital LLC	2.58%	2,724,868	$18.9M
3	Propel Bio Management, LLC	1.27%	350,389	$2.4M
4	Orbimed Advisors LLC	0.73%	5,693,589	$39.4M
5	Parkman Healthcare Partners LLC	0.66%	935,247	$6.5M
6	nVerses Capital, LLC	0.26%	24,029	$166K
7	Bain Capital Life Sciences Investors, LLC	0.25%	600,949	$4.2M
8	Samsara BioCapital, LLC	0.20%	353,717	$2.4M
9	Sphera Funds Management LTD.	0.20%	219,700	$1.5M
10	Verdad Advisers, LP	0.14%	21,810	$151K
11	Stonepine Capital Management, LLC	0.11%	33,432	$231K
12	Y-Intercept (Hong Kong) Ltd	0.09%	693,555	$4.8M
13	Virtus Investment Advisers, LLC	0.09%	53,638	$371K
14	Boxer Capital Management, LLC	0.08%	150,000	$1.0M
15	Voleon Capital Management LP	0.04%	285,234	$2.0M
16	Altshuler Shaham Ltd	0.03%	380,061	$2.6M
17	SEB Asset Management AB	0.02%	878,473	$6.1M
18	XTX Topco Ltd	0.02%	242,346	$1.7M
19	Axq Capital, LP	0.02%	27,068	$187K
20	Trexquant Investment LP	0.02%	466,430	$3.2M
21	Woodline Partners LP	0.02%	831,481	$5.8M
22	Diadema Partners LP	0.02%	19,093	$132K
23	Walleye Capital LLC	0.01%	498,490	$3.4M
24	Persistent Asset Partners Ltd	0.01%	4,855	$34K
25	Algert Global LLC	0.01%	118,630	$821K

Investor	Ownership History	% of Portfolio	Prev %	Rank	Conviction	Avg Buy Price	13F Score™ 3Y / 7Y	Sell Timing	Shares	Mkt Value	Change	Change %	Source	Quarter	Filed

Frequently Asked Questions — Upstream Bio Inc (UPB)

What does the Smart Money Trend signal show for UPB?

Buying streak — 7 quarters in a row: For 7 consecutive quarters, more hedge funds added UPB than sold it. That's a consistent pattern of professional buying — not a one-time trade. When institutions keep buying quarter after quarter, it usually means they see a multi-year opportunity, not just a short-term momentum flip.

What is the institutional breadth score for UPB?

More buyers than sellers — 63% buying: Last quarter: 102 funds were net buyers (37 opened a brand new position + 65 added to an existing one). Only 59 were sellers (29 trimmed + 30 sold completely). A clear majority buying is a strong confirmation signal.

What is the fund quality score for UPB holders?

Elite ownership — 51% AUM from top-100 funds: 42 of 144 holders are among the 100 largest funds by AUM, controlling 51% of total institutional value in UPB. When the biggest players dominate the cap table, it signifies deep institutional support — since mega-funds deploy the most rigorous due diligence and capital.

How long have hedge funds held UPB?

Mostly new holders — 50% entered in last year: Only 6 funds (4%) have held >2 years. The majority of current holders are relatively new to the position. New holders tend to sell faster when prices drop — a shallow conviction base that could amplify any sell-off.

Where does this institutional ownership data come from?

All holdings data is sourced from SEC Form 13F filings, which institutional investment managers with over $100 million in assets are required to submit quarterly. Data is parsed directly from SEC EDGAR.

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Upstream Bio Inc (UPB)

Smart Money Signals — UPB

Buying streak — 7 quarters in a row

At the ownership peak (100% of max)

Fast accumulation — +78% more funds vs a year ago

More buyers than sellers — 63% buying

Fewer new buyers each quarter (-9 vs last Q)

Mostly new holders — 50% entered in last year

Buying through price weakness — shares +10%, value -15%

Growing discovery — still being found

Mixed cohorts — 6% veterans, 54% new entrants

Elite ownership — 51% AUM from top-100 funds

Institutional Sentiment Summary — UPB

Hedge Fund Ownership: UPB

Market Analysis: UPB

Analyst Price Targets

Analyst Recommendations

Stock Performance

Company Profile: UPB

Hedge Fund Positioning: UPB

Statistics: UPB

Valuation Measures Data as of: --

Financial Highlights

Institutional Holders (2026 Q2)

Frequently Asked Questions — Upstream Bio Inc (UPB)

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