Stock Analysis
Data Source: SEC EDGAR 13F
Updated Hourly

UPSTREAM BIO INC COM (UPB)

133 + Investors. Track Smart Money conviction in UPB. See who's accumulating, reducing, or initiating positions.

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Current Price
-- USD
Analyst Target
-- (0 analysts)
Upside
0.00%
Net Flow Q/Q
↑ +34
Streak
5Q ▲
Buyers last Q
66%

Smart Money Signals — UPB

Based on 130 hedge funds · latest filing: 2025 Q4 · updated quarterly

📈

Buying streak — 5 quarters in a row

last 6Q
For 5 consecutive quarters, more hedge funds added UPB than sold it. That's a consistent pattern of professional buying — not a one-time trade. When institutions keep buying quarter after quarter, it usually means they see a multi-year opportunity, not just a short-term momentum flip.
🏔️

At the ownership peak (100% of max)

100% of all-time peak
130 hedge funds hold UPB right now — the highest count in 3.0 years. When ownership is this concentrated, any bad news can trigger a chain reaction: one big fund sells, others follow. This is a classic 'crowded trade' — high popularity doesn't equal safety.
🚀

Fast accumulation — +94% more funds vs a year ago

fund count last 6Q
+63 new funds entered over the past year (+94% YoY). That's a rapid rush of institutional money. Fast accumulation often signals a major thesis — but it also means the stock could fall quickly if that thesis breaks.
🟢

More buyers than sellers — 66% buying

85 buying44 selling
Last quarter: 85 funds were net buyers (44 opened a brand new position + 41 added to an existing one). Only 44 were sellers (34 trimmed + 10 sold completely). A clear majority buying is a strong confirmation signal.
📈

More new buyers each quarter (+19 vs last Q)

new funds entering per quarter
Funds opening a new UPB position: 26 → 14 → 25 → 44. A growing influx of new institutional buyers means the asset is still gathering momentum — the consensus hasn't fully saturated yet.
🔄

Mostly new holders — 47% entered in last year

2% conviction (2yr+) 51% medium 47% new
Only 3 funds (2%) have held >2 years. The majority of current holders are relatively new to the position. New holders tend to sell faster when prices drop — a shallow conviction base that could amplify any sell-off.
💰

Value +65% but shares only +14% — price-driven

Value
+64%
Shares
+14%
Last quarter: the total dollar value of institutional holdings rose +65%, but actual share count only changed +14%. The gap is explained by the stock's price rising — not new buying. Strong value growth with weak share growth means the rally is price momentum, not fresh institutional demand.
🚀

Acceleration phase — new buyers rushing in

67 → 26 → 14 → 25 → 44 new funds/Q
New funds entering each quarter: 26 → 14 → 25 → 44. The pace of institutional discovery is accelerating sharply. This is the 'hot idea' phase — the thesis is being passed from fund to fund. You are not late — the accumulation wave is still building.
🌱

Early stage — 93% of holders entered in last year

7% veterans 0% 1-2yr 93% new
Of 133 current holders: 124 (93%) entered in the past year, only 9 (7%) are 2+ year veterans. This is an early-phase institutional idea — still being discovered. High upside potential if the thesis plays out, but thin conviction base.
🏆

Elite ownership — 43% AUM from top-100 funds

43% from top-100 AUM funds
29 of 130 holders are among the 100 largest funds by AUM, controlling 43% of total institutional value in UPB. When the biggest players dominate the cap table, it signifies deep institutional support — since mega-funds deploy the most rigorous due diligence and capital.
5.2
out of 10
Moderate Exit Risk
Exit risk score 5.2/10 — some crowding factors present, but no critical concentration. Watch ownership trend over the next 1–2 quarters for direction.

Methodology note: these Smart Money cards use consecutive 13F disclosure snapshots, not trade-by-trade execution data. "Buying", "selling", "new holders", and "trimmed" refer to quarter-over-quarter changes in reported holders, aggregate shares, or disclosed position values between filings. They are useful for ownership regime analysis and crowding, but they do not imply exact trade timing on the filing date.

Hedge Fund Ownership: UPB

How many hedge funds hold UPB — quarterly history vs. share price
Quarterly hedge fund ownership of UPB vs. share price

Market Analysis: UPB

Analyst Price Targets

Avg. Price Target
--

Analyst Recommendations

Stock Performance

Real-time

Company Profile: UPB

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Institutional ownership data sourced from SEC EDGAR Form 13F-HR filings.

Smart Money Signal ?
Limited Smart Money Interest

No strong consensus or elite conviction detected among institutional holders.

30 top-rated funds 5 high-conviction
Consensus
6.5
/ 10
breadth
×
Elite
3.8
/ 10
conviction
Hedge Fund Positioning: UPB
2026 Q1 Stats Unlock in 11 days 133 + Investors

Track Smart Money conviction in UPB. See who's accumulating, reducing, or initiating positions.

Metric All 13F Filers (2025 Q4) Prior (2025 Q3) Change
Funds Holding 133 99 34.34%
13F Shares 51M 45M 14.2%
Total Value $1.39B $844M 64.83%
New Positions 46 28 +18
Increased Positions 41 37 +4
Closed Positions 12 11 +1
Reduced Positions 37 22 +15
Total Calls 2 6 -66.67%
Total Puts 2 1 100.0%
PUT/CALL Ratio 1.0 0.17 Neutral

Statistics: UPB

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Valuation Measures Data as of: --

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PEG Ratio (5yr expected) --
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Price/Book (mrq) --
Enterprise Value/Revenue --
Enterprise Value/EBITDA --
Beta (5Y Monthly) --
Short Ratio (Days to Cover) --
Short % of Float --

Financial Highlights

Profitability
Profit Margin --
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Income Statement & Cash Flow
Revenue (ttm) --
Net Income Avi to Common (ttm) --
Diluted EPS (ttm) --
Total Cash (mrq) --
Total Debt/Equity (mrq) --
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Institutional Holders (2026 Q1)

133 + investors

Explore institutional interest and hedge fund ownership dynamics. Analyze portfolio weights, new positions, and conviction trends in UPB. Verified SEC 13F-HR filings.

Top 25 institutional holders of UPB — 2025 Q4 · Source: SEC Form 13F
# Investor % of Portfolio Shares Mkt Value
1 Y-Intercept (Hong Kong) Ltd 0.17% 1,000,631 $9.0M
2 SEB Asset Management AB 0.03% 878,473 $7.9M
3 GSA CAPITAL PARTNERS LLP 0.02% 39,232
4 Simplify Asset Management Inc. 0.01% 77,793 $700K
5 Pictet Asset Management Holding SA 0.01% 733,431 $6.6M
6 China Universal Asset Management Co., Ltd. 0.01% 9,590 $86K
7 Bleakley Financial Group, LLC 0.00% 28,864 $260K
8 HSBC HOLDINGS PLC 0.00% 640,326 $5.8M
9 ALPS ADVISORS INC 0.00% 43,992 $396K
10 Police & Firemen's Retirement System of New Jersey 0.00% 9,456 $85K
11 Torren Management, LLC 0.00% 162 $1K
12 Versant Capital Management, Inc 0.00% 762 $7K
13 NISA INVESTMENT ADVISORS, LLC 0.00% 19,558 $176K
14 DEUTSCHE BANK AG\ 0.00% 180,889 $1.6M
15 VANGUARD FIDUCIARY TRUST CO 0.00% 224,157 $2.0M
16 VANGUARD CAPITAL MANAGEMENT LLC 0.00% 1,873,574 $16.9M
17 STRS OHIO 0.00% 9,800 $88K
18 VANGUARD PORTFOLIO MANAGEMENT LLC 0.00% 727,711 $6.5M
19 UBS Group AG 0.00% 231,254 $2.1M
20 GAMMA Investing LLC 0.00% 715 $6K
21 Swiss National Bank 0.00% 48,100 $433K
22 KLP KAPITALFORVALTNING AS 0.00% 5,900 $53K
23 Sterling Capital Management LLC 0.00% 1,094 $10K
24 GF FUND MANAGEMENT CO. LTD. 0.00% 1,203 $11K
25 N.E.W. Advisory Services LLC 0.00% 120 $1K
Investor Ownership
History
% of Portfolio Prev % Rank Conviction Avg Buy Price 13F Score™ 3Y / 7Y Sell Timing Shares Mkt Value Change Change % Source Quarter Filed

Frequently Asked Questions — UPSTREAM BIO INC COM (UPB)

What does the Smart Money Trend signal show for UPB?

Buying streak — 5 quarters in a row: For 5 consecutive quarters, more hedge funds added UPB than sold it. That's a consistent pattern of professional buying — not a one-time trade. When institutions keep buying quarter after quarter, it usually means they see a multi-year opportunity, not just a short-term momentum flip.

What is the institutional breadth score for UPB?

More buyers than sellers — 66% buying: Last quarter: 85 funds were net buyers (44 opened a brand new position + 41 added to an existing one). Only 44 were sellers (34 trimmed + 10 sold completely). A clear majority buying is a strong confirmation signal.

What is the fund quality score for UPB holders?

Elite ownership — 43% AUM from top-100 funds: 29 of 130 holders are among the 100 largest funds by AUM, controlling 43% of total institutional value in UPB. When the biggest players dominate the cap table, it signifies deep institutional support — since mega-funds deploy the most rigorous due diligence and capital.

How long have hedge funds held UPB?

Mostly new holders — 47% entered in last year: Only 3 funds (2%) have held >2 years. The majority of current holders are relatively new to the position. New holders tend to sell faster when prices drop — a shallow conviction base that could amplify any sell-off.

Where does this institutional ownership data come from?

All holdings data is sourced from SEC Form 13F filings, which institutional investment managers with over $100 million in assets are required to submit quarterly. Data is parsed directly from SEC EDGAR.

Disclaimer: The information on this page is for informational purposes only and does not constitute investment advice, a recommendation, or an offer to buy or sell any security. Institutional holdings data is sourced from SEC Form 13F filings and reflects positions as of the filing date. Past performance of any fund or portfolio is not indicative of future results. 13Foresight is not a registered investment adviser. Always conduct your own due diligence before making investment decisions.