Stock Analysis
Data Source: SEC EDGAR 13F
Updated Hourly

Krystal Biotech Inc (KRYS)

361 + Investors. Track Smart Money conviction in KRYS. See who's accumulating, reducing, or initiating positions.

Current Price
-- USD
Analyst Target
-- (0 analysts)
Upside
0.00%
Net Flow Q/Q
↑ +31
Streak
3Q ▲
Buyers last Q
59%

Smart Money Signals — KRYS

Based on 364 hedge funds · latest filing: 2026 Q1 · updated quarterly

📈

Buying streak — 3 quarters in a row

last 6Q
For 3 consecutive quarters, more hedge funds added KRYS than sold it. That's a consistent pattern of professional buying — not a one-time trade. When institutions keep buying quarter after quarter, it usually means they see a multi-year opportunity, not just a short-term momentum flip.
🏔️

At the ownership peak (100% of max)

100% of all-time peak
364 hedge funds hold KRYS right now — the highest count in 3.0 years. When ownership is this concentrated, any bad news can trigger a chain reaction: one big fund sells, others follow. This is a classic 'crowded trade' — high popularity doesn't equal safety.
🚀

Fast accumulation — +23% more funds vs a year ago

fund count last 6Q
+69 new funds entered over the past year (+23% YoY). That's a rapid rush of institutional money. Fast accumulation often signals a major thesis — but it also means the stock could fall quickly if that thesis breaks.
🟡

Slight buying edge — 59% buying

213 buying148 selling
Last quarter: 213 funds bought or added vs 148 that reduced or exited. It's nearly a 50/50 split — some institutions are convinced, others are taking profits. This mixed picture is normal near price highs.
⚠️

Fewer new buyers each quarter (-12 vs last Q)

new funds entering per quarter
Funds opening this position for the first time: 43 → 45 → 86 → 74. Each quarter fewer new institutions are entering. This usually means most funds that wanted in are already in — the stock is well-known but the pool of potential new buyers is shrinking.
🔒

42% of holders stayed for 2+ years

■ 42% conviction (2yr+) ■ 25% medium ■ 32% new
154 out of 364 hedge funds have held KRYS for over 2 years without selling. Long-term investors are generally harder to shake out during market stress, creating a stable ownership base that limits the risk of sudden capitulation.
🚀

Acceleration phase — new buyers rushing in

63 → 43 → 45 → 86 → 74 new funds/Q
New funds entering each quarter: 43 → 45 → 86 → 74. The pace of institutional discovery is accelerating sharply. This is the 'hot idea' phase — the thesis is being passed from fund to fund. You are not late — the accumulation wave is still building.
🏛️

Veteran-anchored — 47% veterans vs 33% newcomers

■ 47% veterans ■ 20% 1-2yr ■ 33% new
Entry-cohort mix of 374 holders: 174 (47%) are 2+ year veterans, 76 entered 1–2 years ago, and 124 (33%) joined within the past year. A veteran-weighted cap table skews toward institutional memory over fresh momentum.
🏆

Elite ownership — 41% AUM from top-100 funds

41% from top-100 AUM funds
52 of 362 holders are among the 100 largest funds by AUM, controlling 41% of total institutional value in KRYS. When the biggest players dominate the cap table, it signifies deep institutional support — since mega-funds deploy the most rigorous due diligence and capital.
4.3
out of 10
Moderate Exit Risk
Exit risk score 4.3/10 — some crowding factors present, but no critical concentration. Watch ownership trend over the next 1–2 quarters for direction.

Methodology note: these Smart Money cards use consecutive 13F disclosure snapshots, not trade-by-trade execution data. "Buying", "selling", "new holders", and "trimmed" refer to quarter-over-quarter changes in reported holders, aggregate shares, or disclosed position values between filings. They are useful for ownership regime analysis and crowding, but they do not imply exact trade timing on the filing date.

Institutional Sentiment Summary — KRYS

In 2026 Q1, 213 hedge funds were net buyers of KRYS (74 opened a new position, 139 added to an existing one), while 148 reduced or exited (105 trimmed, 43 sold completely) — a 59% buyer ratio, indicating a slight buying edge. This marks 3 consecutive quarters of net institutional buying — a persistent conviction signal. 41% of total institutional value in KRYS is held by top-100 AUM funds, reflecting elite-tier ownership quality. Net fund flow last quarter: +31 funds (more new holders than closures). Total institutional holders: 364.

Hedge Fund Ownership: KRYS

How many hedge funds hold KRYS — quarterly history vs. share price
Quarterly hedge fund ownership of KRYS vs. share price

Market Analysis: KRYS

Analyst Price Targets

Avg. Price Target
--

Analyst Recommendations

Stock Performance

Real-time

Company Profile: KRYS

-- --

Institutional ownership data sourced from SEC EDGAR Form 13F-HR filings.

Is It Too Late to Buy Krystal Biotech Inc (KRYS) Based on Hedge Fund 13F Filings?

Signal Freshness measures how much KRYS has moved relative to its sector benchmark (XLV) since the 2026 Q1 13F filing. A stock that has barely outrun its sector is still a relatively fresh entry point — the fund's thesis has not yet been priced in by the broader market.

Since Quarter End March 31, 2026 · 75d ago
KRYS
+23.1%
XLV
+4.9%

KRYS outperformed XLV by +18.2% since March 31, 2026.

Since 13F Filing Date May 15, 2026 · 30d ago
KRYS
+3.8%
XLV
+6.0%

Since the filing became public, KRYS outperformed XLV by -2.2% .

Interpretation: The stock is tracking its sector benchmark closely. The signal remains fresh and the entry point is still near the fund's implied reference. Learn more →

Smart Money Signal ?
Limited Smart Money Interest

No strong consensus or elite conviction detected among institutional holders.

28 top-rated funds 5 high-conviction
Consensus
6.3
/ 10
breadth
×
Elite
4.2
/ 10
conviction
Hedge Fund Positioning: KRYS
361 + Investors

Track Smart Money conviction in KRYS. See who's accumulating, reducing, or initiating positions.

Metric All 13F Filers (2026 Q1) Prior (2025 Q4) Change
Funds Holding 361 333 8.41%
13F Shares 29M 29M -0.44%
Total Value $7.14B $6.94B 2.92%
New Positions 73 86 -13
Increased Positions 139 107 +32
Closed Positions 45 33 +12
Reduced Positions 99 107 -8
Total Calls 6 6 -
Total Puts 6 4 50.0%
PUT/CALL Ratio 1.0 0.67 Neutral

Statistics: KRYS

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Enterprise Value/EBITDA --
Beta (5Y Monthly) --
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Short % of Float --

Financial Highlights

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Institutional Holders (2026 Q1)

361 + investors

Explore institutional interest and hedge fund ownership dynamics. Analyze portfolio weights, new positions, and conviction trends in KRYS. Verified SEC 13F-HR filings.

QUARTER:
Top 25 KRYS holders by conviction (% of portfolio weight) — 2026 Q1 · Source: SEC Form 13F
# Investor % of Portfolio Shares Mkt Value
1 Act Capital Management, LLC 12.28% 60,477 $15.6M
2 Soleus Capital Management, L.P. 12.06% 1,153,087 $297.9M
3 Redmile Group, LLC 11.52% 673,505 $174.0M
4 S Squared Technology, LLC 8.43% 86,215 $22.3M
5 Avoro Capital Advisors LLC 7.34% 2,888,888 $746.3M
6 Evolutionary Tree Capital Management, LLC 5.98% 12,314 $3.2M
7 Palisades Investment Partners, LLC 4.60% 45,405 $11.7M
8 Frazier Life Sciences Management, L.P. 3.20% 481,307 $124.3M
9 Bellevue Group AG 2.96% 481,785 $124.5M
10 Biondo Investment Advisors, LLC 2.39% 72,045 $18.6M
11 Atle Fund Management AB 2.19% 37,579 $6.8M
12 Elmind Capital, LP 1.61% 22,000 $5.7M
13 Hood River Capital Management LLC 1.60% 619,586 $160.1M
14 Braidwell LP 1.57% 182,425 $47.1M
15 Lisanti Capital Growth, LLC 1.21% 18,515 $4.8M
16 Tetragon Partners GP Ltd 0.99% 19,668 $5.1M
17 Bridge City Capital, LLC 0.86% 12,045 $3.1M
18 Hanseatic Management Services Inc 0.74% 2,997 $774K
19 Privium Fund Management B.V. 0.60% 11,170 $2.9M
20 Quantum Private Wealth, LLC 0.57% 7,181 $1.9M
21 Cim, LLC 0.56% 14,990 $3.9M
22 Rhenman & Partners Asset Management AB 0.53% 16,675 $4.3M
23 AlphaCentric Advisors LLC 0.49% 1,918 $495K
24 Informed Momentum Co LLC 0.49% 16,483 $4.3M
25 Torray Investment Partners LLC 0.46% 12,032 $3.1M
Investor Ownership
History 		% of Portfolio Prev % Rank Conviction Avg Buy Price 13F Score™ 3Y / 7Y Sell Timing Shares Mkt Value Change Change % Source Quarter Filed

Frequently Asked Questions — Krystal Biotech Inc (KRYS)

What does the Smart Money Trend signal show for KRYS?

Buying streak — 3 quarters in a row: For 3 consecutive quarters, more hedge funds added KRYS than sold it. That's a consistent pattern of professional buying — not a one-time trade. When institutions keep buying quarter after quarter, it usually means they see a multi-year opportunity, not just a short-term momentum flip.

What is the institutional breadth score for KRYS?

Slight buying edge — 59% buying: Last quarter: 213 funds bought or added vs 148 that reduced or exited. It's nearly a 50/50 split — some institutions are convinced, others are taking profits. This mixed picture is normal near price highs.

What is the fund quality score for KRYS holders?

Elite ownership — 41% AUM from top-100 funds: 52 of 362 holders are among the 100 largest funds by AUM, controlling 41% of total institutional value in KRYS. When the biggest players dominate the cap table, it signifies deep institutional support — since mega-funds deploy the most rigorous due diligence and capital.

How long have hedge funds held KRYS?

42% of holders stayed for 2+ years: 154 out of 364 hedge funds have held KRYS for over 2 years without selling. Long-term investors are generally harder to shake out during market stress, creating a stable ownership base that limits the risk of sudden capitulation.

Is it too late to buy Krystal Biotech Inc (KRYS) following the 2026 Q1 hedge fund 13F filings?

As of today, KRYS has moved +3.8% since the 2026 Q1 13F filing date (May 15, 2026), compared to +6.0% for the XLV sector ETF — an outperformance of -2.2%. Since the quarter end (March 31, 2026), KRYS has gained +23.1% vs +4.9% for XLV. The stock is tracking its sector benchmark closely. The signal remains fresh and the entry point is still near the fund's implied reference.

Where does this institutional ownership data come from?

All holdings data is sourced from SEC Form 13F filings, which institutional investment managers with over $100 million in assets are required to submit quarterly. Data is parsed directly from SEC EDGAR.

Disclaimer: The information on this page is for informational purposes only and does not constitute investment advice, a recommendation, or an offer to buy or sell any security. Institutional holdings data is sourced from SEC Form 13F filings and reflects positions as of the filing date. Past performance of any fund or portfolio is not indicative of future results. 13Foresight is not a registered investment adviser. Always conduct your own due diligence before making investment decisions.

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