TCG Crossover Management, LLC

All Holdings — 2025 Q4

AI Portfolio Summary
In 2025 Q4, TCG Crossover Management, LLC maintained a portfolio of 48 distinct positions. The most significant new addition to the portfolio was MONTE ROSA THERAPEUT, which now represents 2.40% of the total fund value. They heavily accumulated shares in TANGO THERAPEUTICS I, increasing their position by 49.5%. Conversely, TCG Crossover Management, LLC completely exited their position in PEPGEN INC.
PCA Score Concentration Risk
Risk ENB
Total Positions
48
Quarter
2025 Q4
Top Holding
ABVX (31.7%)
Top 10 Concentration
64.3%
Turnover Rate
23.4%
Sector HHI
0.18
Items per page:
Showing 1-48 of 48
Stock History Sector / Type Port % Prev % Rank / Prev Conviction Change % Change Influence Shares Mkt Value Avg Cost Price Held 1st Owned Source Source Date Date Reported
ABVX
ABIVAX SA AMERI...
Healthcare 31.74% 29.70% #1
Prev: #1
7.0 no change no change
P
S
7,111,596 $959,034,279
$25.80 +418.5%
$134.85 -0.8%
2023 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
COGT
COGENT BIOSCIEN...
Healthcare 6.90% 4.80% #2 1
Prev: #3
4.8 -930,000 -13.7%
P
S
5,868,162 $208,437,114
$9.40 +269.4%
$35.52 -2.2%
2021 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
CGON
CG ONCOLOGY INC
Healthcare 5.04% 7.27% #3 1
Prev: #2
4.0 no change no change
P
S
3,670,206 $152,386,953
$43.56 -4.1%
$41.52 +0.7%
2024 Q1 13F Filing 2025-12-31 2026-02-14 (Est.)
TNGX
TANGO THERAPEUT...
Healthcare 3.74% 3.53% #4 2
Prev: #6
4.5 4,225,898 49.5%
P
S
12,762,094 $113,072,153 2022 Q1 13F Filing 2025-12-31 2026-02-14 (Est.)
CNTA
CENTESSA PHARMA...
Healthcare 3.55% 3.74% #5
Prev: #5
4.4 1,150,000 36.7%
P
S
4,286,480 $107,204,865 2023 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
DYN
DYNE THERAPEUTI...
Healthcare 2.99% 2.87% #6 4
Prev: #10
2.2 no change no change
P
S
4,615,144 $90,272,217 2023 Q1 13F Filing 2025-12-31 2026-02-14 (Est.)
RAPT
RAPT THERAPEUTI...
Healthcare 2.89% 2.08% #7 8
Prev: #15
4.2 946,133 57.8%
P
S
2,582,408 $87,466,159 2024 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
TYRA
TYRA BIOSCIENCE...
Healthcare 2.52% 1.99% #8 8
Prev: #16
2.0 no change no change
P
S
2,898,103 $76,191,128 2021 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
AMLX
AMYLYX PHARMACE...
Healthcare 2.50% 4.17% #9 5
Prev: #4
2.0 no change no change
P
S
6,243,812 $75,425,249 2024 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
SVRA
SAVARA INC
Healthcare 2.47% 2.17% #10 4
Prev: #14
2.0 no change no change
P
S
12,362,205 $74,544,096 2023 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
GLUE
MONTE ROSA THER...
Healthcare 2.40% #11
Prev: #—
4.5 4,622,151 no change
NEW
4,622,151 $72,475,328 2025 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
OCUL
OCULAR THERAPEU...
Healthcare 2.31% 3.52% #12 5
Prev: #7
1.4 -377,001 -6.2%
P
S
5,740,231 $69,686,404 2024 Q1 13F Filing 2025-12-31 2026-02-14 (Est.)
DNTH
DIANTHUS THERAP...
Healthcare 2.29% 3.25% #13 5
Prev: #8
1.9 no change no change
P
S
1,676,624 $69,093,675 2024 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
EYPT
EYEPOINT PHARMA...
Healthcare 2.16% 2.50% #14 2
Prev: #12
1.9 no change no change
P
S
3,572,335 $65,266,560 2024 Q2 13F Filing 2025-12-31 2026-02-14 (Est.)
GPCR
STRUCTURE THERA...
Healthcare 2.12% 1.46% #15 5
Prev: #20
1.3 -142,143 -13.4%
P
S
920,857 $64,045,604 2023 Q1 13F Filing 2025-12-31 2026-02-14 (Est.)
SYRE
SPYRE THERAPEUT...
Healthcare 2.06% 0.91% #16 11
Prev: #27
3.8 800,000 72.7%
P
S
1,900,582 $62,263,066 2025 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
FULC
FULCRUM THERAPE...
Healthcare 1.97% 2.38% #17 4
Prev: #13
1.8 no change no change
P
S
5,250,000 $59,377,500 2024 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
LQDA
LIQUIDIA TECHNO...
Healthcare 1.95% 1.91% #18
Prev: #18
1.8 no change no change
P
S
1,710,084 $58,980,797 2025 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
BHVN
BIOHAVEN LTD
Healthcare 1.73% #19
Prev: #—
4.2 4,631,317 no change
NEW
4,631,317 $52,287,569 2025 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
IMVT
IMMUNOVANT INC
Healthcare 1.40% #20
Prev: #—
4.1 1,660,933 no change
NEW
1,660,933 $42,220,917 2022 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
KOD
KODIAK SCIENCES...
Healthcare 1.34% 0.92% #21 5
Prev: #26
3.0 300,000 26.2%
P
S
1,445,538 $40,417,243 2023 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
ADCT
ADC THERAPEUTIC...
Healthcare 1.33% 0.27% #22 15
Prev: #37
3.5 10,000,000 719.3%
P
S
11,390,175 $40,207,318 2025 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
LBRX
LB PHARMACEUTIC...
Healthcare 1.29% 1.36% #23 1
Prev: #22
1.0 -1 -0.0%
P
S
1,745,015 $38,844,034 2025 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
XNCR
XENCOR INC
Healthcare 1.24% 1.41% #24 3
Prev: #21
1.5 no change no change
P
S
2,452,138 $37,542,233 2024 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
RVMD
REVOLUTION MEDI...
Healthcare 1.15% 1.00% #25 2
Prev: #23
1.5 no change no change
P
S
436,473 $34,765,074 2025 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
AGIO
AGIOS PHARMACEU...
Healthcare 1.06% 2.82% #26 15
Prev: #11
0.9 -248,200 -17.4%
P
S
1,181,841 $32,169,712 2025 Q2 13F Filing 2025-12-31 2026-02-14 (Est.)
ARVN
ARVINAS HOLDING...
Healthcare 1.05% 0.68% #27 3
Prev: #30
3.4 1,048,851 64.8%
P
S
2,666,216 $31,621,322 2025 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
RLAY
RELAY THERAPEUT...
Healthcare 0.90% 0.46% #28 6
Prev: #34
3.4 1,409,835 77.9%
P
S
3,220,186 $27,242,774 2025 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
JANX
JANUX THERAPEUT...
Healthcare 0.82% #29
Prev: #—
3.8 1,789,617 no change
NEW
1,789,617 $24,696,715 2025 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
TRDA
ENTRADA THERAPE...
Healthcare 0.71% 0.17% #30 9
Prev: #39
3.3 1,503,437 257.0%
P
S
2,088,392 $21,468,670 2021 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
MBX
MBX BIOSCIENCES...
Healthcare 0.68% 0.56% #31 1
Prev: #32
1.3 no change no change
P
S
650,000 $20,501,000 2024 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
UPB
UPSTREAM BIO IN...
Healthcare 0.67% 1.96% #32 15
Prev: #17
0.3 -1,373,217 -64.9%
P
S
743,886 $20,196,505 2024 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
SLN
SILENCE THERAPE...
Healthcare 0.61% 0.77% #33 5
Prev: #28
1.2 no change no change
P
S
3,033,560 $18,444,045 2022 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
URGN
UROGEN PHARMA L...
Healthcare 0.56% 0.70% #34 5
Prev: #29
1.2 no change no change
P
S
717,347 $16,800,267 2025 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
ALEC
ALECTOR INC
Healthcare 0.52% #35
Prev: #—
3.7 10,000,000 no change
NEW
10,000,000 $15,600,000 2025 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
MNPR
MONOPAR THERAPE...
Healthcare 0.31% 0.61% #36 5
Prev: #31
0.6 -11,085 -7.2%
P
S
141,915 $9,267,050 2025 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
AVTX
AVALO THERAPEUT...
Healthcare 0.29% 0.30% #37 1
Prev: #36
1.1 no change no change
P
S
483,000 $8,771,280 2024 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
MAZE
MAZE THERAPEUTI...
Healthcare 0.24% #38
Prev: #—
3.6 173,816 no change
NEW
173,816 $7,201,197 2025 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
MIRM
MIRUM PHARMACEU...
Healthcare 0.16% #39
Prev: #—
3.6 62,049 no change
NEW
62,049 $4,901,251 2025 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
LONA
Athira Pharma, ...
Healthcare 0.11% #40
Prev: #—
3.5 464,398 no change
NEW
464,398 $3,348,507 2025 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
KRRO
KORRO BIO INC
Healthcare 0.11% 0.98% #41 16
Prev: #25
1.0 no change no change
P
S
416,301 $3,334,571 2025 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
VTYX
VENTYX BIOSCIEN...
Healthcare 0.09% 0.05% #42 2
Prev: #40
1.0 no change no change
P
S
316,195 $2,855,241 2022 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
VTGN
VISTAGEN THERAP...
Healthcare 0.06% 0.47% #43 10
Prev: #33
1.0 no change no change
P
S
2,676,580 $1,771,628 2023 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
PEPG
PEPGEN INC
Healthcare 0.00% 0.27%
Sold All 😨
(Was: #38)
0.0 -1,200,000 -100.0%
CLOSED
$— 2025 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
ADVM
ADVERUM BIOTECH...
Healthcare 0.00% 0.37%
Sold All 😨
(Was: #35)
0.0 -1,668,174 -100.0%
CLOSED
$— 2024 Q1 13F Filing 2025-12-31 2026-02-14 (Est.)
ATXS
ASTRIA THERAPEU...
Healthcare 0.00% 0.99%
Sold All 😨
(Was: #24)
0.0 -2,761,861 -100.0%
CLOSED
$— 2024 Q1 13F Filing 2025-12-31 2026-02-14 (Est.)
IRON
DISC MEDICINE I...
Healthcare 0.00% 1.51%
Sold All 😨
(Was: #19)
0.0 -465,257 -100.0%
CLOSED
$— 2024 Q2 13F Filing 2025-12-31 2026-02-14 (Est.)
TRML
TOURMALINE BIO ...
Unknown 0.00% 3.09%
Sold All 😨
(Was: #9)
0.0 -1,311,783 -100.0%
CLOSED
$— 2023 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
Showing 1-48 of 48 holdings

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