2026 Q2 Portfolio Activity
In 2026 Q2, Opaleye Management Inc. maintained a portfolio of 67 distinct positions. The most significant new addition was IMMIX BIOPHARMA INC, now representing 2.19% of the total fund value. They heavily accumulated shares in DISC MEDICINE INC, increasing the position by 103.1%. Conversely, Opaleye Management Inc. completely exited their position in PERSPECTIVE THERAPEUTICS INC.
Position History
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Total Positions
67
Quarter
2026 Q2
Top Holding
LQDA (17.7%)
Top 10 Concentration
64.8%
Turnover Rate
23.4%
Sector HHI
0.18
Items per page:
Showing 1-50 of 67
Opaleye Management Inc. Full Holdings List — 2026 Q2
| Stock | History | Sector / Type | Port % | Prev % | Rank / Prev | Conviction | Change | % Change | Influence | Shares | Mkt Value | Avg Cost | Price Held | 1st Owned | Source | Source Date | Date Reported | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
LQDA
LIQUIDIA CORPOR...
|
Healthcare | 17.67% | 11.70% |
#1
1
Prev: #2
|
6.5 |
—
|
-97,500 | -3.8% |
P
S
|
2,447,500 | $195,139,175 | 2019 Q1 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
ETON
ETON PHARMACEUT...
|
Healthcare | 9.38% | 9.30% |
#2
1
Prev: #3
|
6.3 |
—
|
no change | no change |
P
S
|
2,860,000 | $103,532,000 | 2018 Q4 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
HROW
HARROW INC
|
Healthcare | 9.23% | 13.15% |
#3
2
Prev: #1
|
5.2 |
—
|
-432,230 | -15.3% |
P
S
|
2,400,000 | $101,928,000 | 2020 Q2 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
IRON
DISC MEDICINE I...
|
Healthcare | 5.66% | 3.55% |
#4
3
Prev: #7
|
5.8 |
—
|
434,000 | 103.1% |
P
S
|
855,000 | $62,534,700 | 2025 Q1 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
URGN
UROGEN PHARMA L...
|
Healthcare | 4.80% | 3.39% |
#5
3
Prev: #8
|
2.9 |
—
|
9,996 | 0.7% |
P
S
|
1,439,996 | $52,991,853 | 2022 Q2 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
APGE
APOGEE THERAPEU...
|
Healthcare | 4.69% | 4.32% |
#6
Prev: #6
|
2.9 |
—
|
no change | no change |
P
S
|
390,000 | $51,764,700 | 2025 Q3 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
MGTX
MEIRAGTX HLDGS ...
|
Healthcare | 4.34% | 2.42% |
#7
6
Prev: #13
|
4.7 |
—
|
1,426,741 | 67.2% |
P
S
|
3,550,000 | $47,960,500 | 2022 Q3 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
SLGL
SOL-GEL TECHNOL...
|
Healthcare | 3.36% | 5.22% |
#8
4
Prev: #4
|
2.3 |
—
|
no change | no change |
P
S
|
500,000 | $37,070,000 | 2025 Q3 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
RZLT
REZOLUTE INC
|
Healthcare | 2.97% | 2.53% |
#9
3
Prev: #12
|
2.2 |
—
|
no change | no change |
P
S
|
6,300,000 | $32,760,000 | 2024 Q3 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
TGTX
TG THERAPEUTICS...
|
Healthcare | 2.66% | 2.34% |
#10
4
Prev: #14
|
2.1 |
—
|
no change | no change |
P
S
|
535,000 | $29,392,900 | 2015 Q3 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
IMMX
IMMIX BIOPHARMA...
|
Healthcare | 2.19% | — |
#11
Prev: #—
|
4.4 |
—
|
2,345,000 | — |
NEW
|
2,345,000 | $24,176,950 | 2026 Q2 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
N/A
CRESCENT BIOPHA...
|
|
Unknown | 2.15% | 3.18% |
#12
3
Prev: #9
|
1.4 |
—
|
6,736 | 0.5% |
P
S
|
1,319,351 | $23,748,318 | — | 13F Filing | 2026-06-30 | 2026-08-14 | ||
|
STOK
STOKE THERAPEUT...
|
Healthcare | 2.07% | 3.00% |
#13
3
Prev: #10
|
1.8 |
—
|
no change | no change |
P
S
|
700,000 | $22,904,000 | 2024 Q4 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
ACOG
ALPHA COGNITION...
|
Healthcare | 1.89% | 1.85% |
#14
3
Prev: #17
|
2.8 |
—
|
333,517 | 13.0% |
P
S
|
2,895,467 | $20,905,272 | 2025 Q3 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
EWTX
EDGEWISE THERAP...
|
Healthcare | 1.84% | 2.07% |
#15
1
Prev: #16
|
1.7 |
—
|
no change | no change |
P
S
|
500,000 | $20,315,000 | 2022 Q1 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
RVMD
REVOLUTION MEDI...
|
Healthcare | 1.70% | 1.28% |
#16
6
Prev: #22
|
1.7 |
—
|
no change | no change |
P
S
|
100,000 | $18,728,000 | 2025 Q2 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
GLUE
MONTE ROSA THER...
|
Healthcare | 1.63% | — |
#17
Prev: #—
|
4.2 |
—
|
745,000 | — |
NEW
|
745,000 | $18,029,000 | 2026 Q2 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
ALMS
ALUMIS INC
|
Healthcare | 1.40% | 1.60% |
#18
1
Prev: #19
|
1.6 |
—
|
no change | no change |
P
S
|
550,000 | $15,477,000 | 2025 Q2 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
CDXS
CODEXIS INC
|
Healthcare | 1.39% | 1.46% |
#19
1
Prev: #20
|
1.6 |
—
|
no change | no change |
P
S
|
6,785,000 | $15,334,100 | 2014 Q1 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
REPL
REPLIMUNE GROUP...
|
Healthcare | 1.39% | — |
#20
Prev: #—
|
4.1 |
—
|
1,384,993 | — |
NEW
|
1,384,993 | $15,331,873 | 2026 Q2 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
XOMA
XOMA ROYALTY CO...
|
Healthcare | 1.30% | 1.24% |
#21
2
Prev: #23
|
2.5 |
—
|
38,374 | 12.8% |
P
S
|
338,374 | $14,380,895 | 2017 Q1 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
MBX
MBX BIOSCIENCES...
|
Healthcare | 1.30% | 1.02% |
#22
3
Prev: #25
|
1.5 |
—
|
no change | no change |
P
S
|
260,000 | $14,352,000 | 2025 Q1 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
RYTM
RHYTHM PHARMACE...
|
Healthcare | 1.23% | 4.65% |
#23
18
Prev: #5
|
1.0 |
—
|
-500 | -0.4% |
P
S
|
122,500 | $13,601,175 | 2017 Q4 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
EDIT
EDITAS MEDICINE...
|
Healthcare | 1.13% | 0.63% |
#24
7
Prev: #31
|
3.5 |
—
|
1,934,933 | 100.4% |
P
S
|
3,861,930 | $12,512,653 | 2026 Q1 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
PTGX
PROTAGONIST THE...
|
Healthcare | 1.11% | 1.39% |
#25
4
Prev: #21
|
1.4 |
—
|
no change | no change |
P
S
|
100,000 | $12,258,000 | 2020 Q4 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
CABA
CABALETTA BIO I...
|
Healthcare | 1.09% | 0.49% |
#26
11
Prev: #37
|
3.4 |
—
|
2,483,800 | 180.0% |
P
S
|
3,863,800 | $12,016,418 | 2025 Q3 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
QTTB
Q32 BIO INC
|
Healthcare | 1.07% | 1.06% |
#27
3
Prev: #24
|
0.4 |
—
|
-325,228 | -25.9% |
P
S
|
931,000 | $11,860,940 | 2025 Q4 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
ANNX
ANNEXON INC
|
Healthcare | 0.89% | 1.70% |
#28
10
Prev: #18
|
0.4 |
—
|
-617,310 | -26.5% |
P
S
|
1,714,451 | $9,789,515 | 2025 Q3 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
VSTM
VERASTEM INC
|
Healthcare | 0.62% | — |
#29
Prev: #—
|
3.7 |
—
|
1,800,000 | — |
NEW
|
1,800,000 | $6,876,000 | 2023 Q2 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
ZNTL
ZENTALIS PHARMA...
|
Healthcare | 0.62% | 0.44% |
#30
10
Prev: #40
|
1.2 |
—
|
no change | no change |
P
S
|
1,412,656 | $6,851,382 | 2022 Q4 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
RLMD
RELMADA THERAPE...
|
Healthcare | 0.59% | 0.86% |
#31
5
Prev: #26
|
1.2 |
—
|
no change | no change |
P
S
|
935,000 | $6,470,200 | 2023 Q3 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
OCUL
OCULAR THERAPEU...
|
Healthcare | 0.53% | 0.67% |
#32
3
Prev: #29
|
1.2 |
—
|
no change | no change |
P
S
|
600,000 | $5,892,000 | 2016 Q4 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
TRVI
TREVI THERAPEUT...
|
Healthcare | 0.52% | 0.54% |
#33
2
Prev: #35
|
0.7 |
—
|
-35,100 | -10.2% |
P
S
|
310,000 | $5,781,500 | 2022 Q4 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
BBOT
BRIDGEBIO ONCOL...
|
Healthcare | 0.48% | 0.06% |
#34
18
Prev: #52
|
3.2 |
—
|
646,718 | 1213.8% |
P
S
|
700,000 | $5,334,000 | 2026 Q1 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
LYEL
LYELL IMMUNOPHA...
|
Healthcare | 0.44% | 0.21% |
#35
11
Prev: #46
|
3.2 |
—
|
264,928 | 334.9% |
P
S
|
344,025 | $4,833,551 | 2024 Q1 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
IRD
OPUS GENETICS I...
|
Healthcare | 0.42% | 0.30% |
#36
7
Prev: #43
|
0.7 |
—
|
5,000 | 0.4% |
P
S
|
1,125,000 | $4,623,750 | 2025 Q1 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
FDMT
4D MOLECULAR TH...
|
Healthcare | 0.40% | 0.14% |
#37
12
Prev: #49
|
3.2 |
—
|
222,146 | 197.8% |
P
S
|
334,437 | $4,448,012 | 2021 Q4 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
NTLA
INTELLIA THERAP...
|
Healthcare | 0.38% | 0.41% |
#38
3
Prev: #41
|
0.7 |
—
|
5,000 | 2.0% |
P
S
|
250,000 | $4,230,000 | 2023 Q2 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
VYGR
VOYAGER THERAPE...
|
Healthcare | 0.38% | 0.58% |
#39
5
Prev: #34
|
0.7 |
—
|
35,000 | 3.0% |
P
S
|
1,185,000 | $4,147,500 | 2025 Q4 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
BDSX
BIODESIX INC
|
Healthcare | 0.37% | 0.45% |
#40
2
Prev: #38
|
0.1 |
—
|
-58,047 | -24.4% |
P
S
|
180,000 | $4,059,000 | 2023 Q3 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
RCKT
ROCKET PHARMACE...
|
Healthcare | 0.31% | 0.45% |
#41
2
Prev: #39
|
0.6 |
—
|
45,000 | 4.7% |
P
S
|
1,000,000 | $3,420,000 | 2025 Q4 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
JBIO
JADE BIOSCIENCE...
|
Healthcare | 0.29% | 0.79% |
#42
14
Prev: #28
|
0.1 |
—
|
-282,608 | -66.1% |
P
S
|
145,000 | $3,221,900 | 2025 Q4 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
SNWV
SANUWAVE HEALTH...
|
Healthcare | 0.28% | 2.23% |
#43
28
Prev: #15
|
0.1 |
—
|
-675,127 | -68.8% |
P
S
|
306,140 | $3,061,400 | 2025 Q1 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
FBIO
FORTRESS BIOTEC...
|
Healthcare | 0.25% | 0.38% |
#44
2
Prev: #42
|
0.6 |
—
|
-152,000 | -14.6% |
P
S
|
890,000 | $2,723,400 | 2025 Q4 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
DERM
JOURNEY MED COR...
|
Healthcare | 0.22% | 0.59% |
#45
12
Prev: #33
|
0.1 |
—
|
-610,000 | -63.5% |
P
S
|
350,000 | $2,478,000 | 2015 Q2 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
PHAT
PHATHOM PHARMAC...
|
Healthcare | 0.18% | — |
#46
Prev: #—
|
3.6 |
—
|
185,589 | — |
NEW
|
185,589 | $2,013,641 | 2022 Q4 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
INBX
INHIBRX BIOSCIE...
|
Healthcare | 0.17% | — |
#47
Prev: #—
|
3.6 |
—
|
20,291 | — |
NEW
|
20,291 | $1,922,572 | 2022 Q2 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
ENTA
ENANTA PHARMACE...
|
Healthcare | 0.17% | 0.21% |
#48
1
Prev: #47
|
1.1 |
—
|
no change | no change |
P
S
|
125,000 | $1,822,500 | 2016 Q4 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
COAG
HEMAB THERAPEUT...
|
Healthcare | 0.16% | — |
#49
Prev: #—
|
3.6 |
—
|
47,652 | — |
NEW
|
47,652 | $1,750,258 | 2026 Q2 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
TRAX
FIRST TRACKS BI...
|
Healthcare | 0.12% | — |
#50
Prev: #—
|
3.5 |
—
|
65,000 | — |
NEW
|
65,000 | $1,307,800 | 2026 Q2 | 13F Filing | 2026-06-30 | 2026-08-14 |
Showing 1-50 of 67 holdings