AI Portfolio Summary
In 2025 Q4, Opaleye Management Inc. maintained a portfolio of 64 distinct positions. The most significant new addition to the portfolio was CRESCENT BIOPHARMA I, which now represents 1.84% of the total fund value. They heavily accumulated shares in APOGEE THERAPEUTICS , increasing their position by 6.9%. Conversely, Opaleye Management Inc. completely exited their position in IMMUNOME INC.
Total Positions
64
Quarter
2025 Q4
Top Holding
HROW (25.2%)
Top 10 Concentration
65.5%
Turnover Rate
23.4%
Sector HHI
0.18
Items per page:
1-25 of 64
| Stock | History | Sector / Type | Port % | Prev % | Rank / Prev | Conviction | Change | % Change | Influence | Shares | Mkt Value | Avg Cost | Price Held | 1st Owned | Source | Source Date | Date Reported |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
HROW
HARROW HEALTH I...
|
Healthcare | 25.24% | 26.60% |
#1
Prev: #1
|
10.0 | no change | no change |
P
S
|
3,905,000 | $191,345,000 | 2020 Q2 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
LQDA
LIQUIDIA CORPOR...
|
Healthcare | 11.21% | 8.41% |
#2
1
Prev: #3
|
4.5 | -180,000 | -6.9% |
P
S
|
2,435,000 | $84,981,500 | 2019 Q1 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
ETON
ETON PHARMACEUT...
|
Healthcare | 6.38% | 8.79% |
#3
1
Prev: #2
|
2.6 | no change | no change |
P
S
|
2,860,000 | $48,362,600 | 2018 Q4 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
RYTM
RHYTHM PHARMACE...
|
Healthcare | 4.66% | 6.59% |
#4
Prev: #4
|
1.9 | -131,700 | -28.5% |
P
S
|
330,000 | $35,323,200 | 2017 Q4 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
APGE
APOGEE THERAPEU...
|
Healthcare | 3.87% | 2.04% |
#5
7
Prev: #12
|
3.6 | 25,000 | 6.9% |
P
S
|
388,257 | $29,305,638 | 2025 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
SNWV
SANUWAVE HEALTH...
|
Healthcare | 3.86% | 5.19% |
#6
Prev: #6
|
3.5 | 1,267 | 0.1% |
P
S
|
981,267 | $29,281,007 | 2025 Q1 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
STOK
STOKE THERAPEUT...
|
Healthcare | 2.91% | 2.27% |
#7
4
Prev: #11
|
3.2 | 12,983 | 1.9% |
P
S
|
695,000 | $22,059,300 | 2024 Q4 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
OCUL
OCULAR THERAPEU...
|
Healthcare | 2.55% | 2.64% |
#8
1
Prev: #9
|
1.0 | no change | no change |
P
S
|
1,595,000 | $19,363,300 | 2016 Q4 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
SLGL
SOL GEL TECHNOL...
|
Healthcare | 2.52% | 0.84% |
#9
16
Prev: #25
|
3.3 | 248,904 | 121.5% |
P
S
|
453,739 | $19,120,561 | 2025 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
CGON
CG ONCOLOGY INC
|
Healthcare | 2.25% | 2.33% |
#10
Prev: #10
|
0.9 | no change | no change |
P
S
|
410,000 | $17,023,200 | 2025 Q1 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
TGTX
TG THERAPEUTICS...
|
Healthcare | 2.10% | 2.73% |
#11
3
Prev: #8
|
0.8 | no change | no change |
P
S
|
535,000 | $15,948,350 | 2015 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
IRON
DISC MEDICINE I...
|
Healthcare | 2.10% | 1.81% |
#12
2
Prev: #14
|
2.8 | 6,227 | 3.2% |
P
S
|
200,000 | $15,882,000 | 2025 Q1 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
RZLT
REZOLUTE INC
|
Healthcare | 1.96% | 1.20% |
#13
5
Prev: #18
|
3.1 | 5,383,714 | 595.9% |
P
S
|
6,287,156 | $14,837,688 | 2024 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
N/A
CRESCENT BIOPHA...
|
—
|
Unknown | 1.84% | — |
#14
Prev: #—
|
2.7 | 1,178,300 | no change |
NEW
|
1,178,300 | $13,974,638 | — | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | ||
|
ALKS
ALKERMES PLC
|
Healthcare | 1.81% | 1.91% |
#15
2
Prev: #13
|
2.8 | 40,000 | 8.9% |
P
S
|
490,000 | $13,710,200 | 2025 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
ACOG
ALPHA COGNITION...
|
Healthcare | 1.78% | 0.11% |
#16
23
Prev: #39
|
3.0 | 1,955,642 | 1698.5% |
P
S
|
2,070,784 | $13,460,096 | 2025 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
ANNX
ANNEXON INC
|
Healthcare | 1.72% | 1.12% |
#17
4
Prev: #21
|
0.7 | no change | no change |
P
S
|
2,600,000 | $13,052,000 | 2025 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
EWTX
EDGEWISE THERAP...
|
Healthcare | 1.64% | 1.15% |
#18
2
Prev: #20
|
0.7 | no change | no change |
P
S
|
500,000 | $12,407,500 | 2022 Q1 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
CDXS
CODEXIS INC
|
Healthcare | 1.46% | 4.41% |
#19
12
Prev: #7
|
0.7 | -6,005,262 | -46.9% |
P
S
|
6,789,738 | $11,067,273 | 2014 Q1 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
PTGX
PROTAGONIST THE...
|
Healthcare | 1.21% | 0.99% |
#20
3
Prev: #23
|
0.5 | no change | no change |
P
S
|
105,000 | $9,170,700 | 2020 Q4 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
GOSS
GOSSAMER BIO IN...
|
Healthcare | 1.11% | 1.01% |
#21
1
Prev: #22
|
0.4 | -5,000 | -0.2% |
P
S
|
2,720,000 | $8,432,000 | 2023 Q2 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
MBX
MBX BIOSCIENCES...
|
Healthcare | 1.08% | 0.63% |
#22
8
Prev: #30
|
2.4 | 7,000 | 2.8% |
P
S
|
260,000 | $8,200,400 | 2025 Q1 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
RVMD
REVOLUTION MEDI...
|
Healthcare | 1.05% | 0.66% |
#23
5
Prev: #28
|
0.4 | no change | no change |
P
S
|
100,000 | $7,965,000 | 2025 Q2 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
XOMA
XOMA CORP DEL
|
Healthcare | 1.03% | 1.39% |
#24
7
Prev: #17
|
2.5 | 37,503 | 14.7% |
P
S
|
292,590 | $7,779,968 | 2017 Q1 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
DERM
JOURNEY MEDICAL...
|
Healthcare | 0.99% | 0.98% |
#25
1
Prev: #24
|
2.4 | 3,936 | 0.4% |
P
S
|
975,000 | $7,517,250 | 2015 Q2 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
IMNM
IMMUNOME INC
|
Healthcare | 0.00% | 5.27% |
Sold All 😨
(Was: #5) |
0.3 | -3,185,000 | -100.0% |
CLOSED
|
— | $— | 2024 Q2 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
SRPT
SAREPTA THERAPE...
|
Healthcare | 0.00% | 1.59% |
Sold All 😨
(Was: #15) |
0.3 | -585,000 | -100.0% |
CLOSED
|
— | $— | 2025 Q2 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
LRMR
LARIMAR THERAPE...
|
Healthcare | 0.00% | 1.49% |
Sold All 😨
(Was: #16) |
0.3 | -3,720,867 | -100.0% |
CLOSED
|
— | $— | 2021 Q2 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
ARVN
ARVINAS INC
|
Healthcare | 0.00% | 1.19% |
Sold All 😨
(Was: #19) |
0.3 | -987,818 | -100.0% |
CLOSED
|
— | $— | 2019 Q2 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
TMCI
TREACE MEDICAL ...
|
Healthcare | 0.00% | 0.67% |
Sold All 😨
(Was: #27) |
0.3 | -702,245 | -100.0% |
CLOSED
|
— | $— | 2025 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
N/A
KARYOPHARM THER...
|
—
|
Bond/Debt | 0.00% | 0.65% |
Sold All 😨
(Was: #29) |
0.3 | -6,000,000 | -100.0% |
CLOSED
|
— | $— | — | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | ||
|
ADCT
ADC Therapeutic...
|
Healthcare | 0.00% | 0.39% |
Sold All 😨
(Was: #32) |
0.3 | -682,529 | -100.0% |
CLOSED
|
— | $— | 2025 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
SYRE
SPYRE THERAPEUT...
|
Healthcare | 0.00% | 0.15% |
Sold All 😨
(Was: #37) |
0.3 | -65,000 | -100.0% |
CLOSED
|
— | $— | 2025 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
PEPG
PEPGEN INC
|
Healthcare | 0.00% | 0.05% |
Sold All 😨
(Was: #41) |
0.3 | -75,000 | -100.0% |
CLOSED
|
— | $— | 2024 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
IBIO
IBIO INC
|
Healthcare | 0.00% | 0.04% |
Sold All 😨
(Was: #42) |
0.3 | -375,000 | -100.0% |
CLOSED
|
— | $— | 2024 Q1 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) |
Showing 1-25 of 64 holdings