AI Portfolio Summary
In 2025 Q4, EcoR1 Capital, LLC maintained a portfolio of 41 distinct positions. The most significant new addition to the portfolio was CG ONCOLOGY INC, which now represents 1.45% of the total fund value. They heavily accumulated shares in CENTESSA PHARMACEUTI, increasing their position by 466.4%. Conversely, EcoR1 Capital, LLC completely exited their position in COMPASS PATHWAYS PLC.
Total Positions
41
Quarter
2025 Q4
Top Holding
ZYME (27.4%)
Top 10 Concentration
84.6%
Turnover Rate
23.4%
Sector HHI
0.18
Items per page:
Showing 1-41 of 41
| Stock | History | Sector / Type | Port % | Prev % | Rank / Prev | Conviction | Change | % Change | Influence | Shares | Mkt Value | Avg Cost | Price Held | 1st Owned | Source | Source Date | Date Reported |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
ZYME
ZYMEWORKS INC
|
Healthcare | 27.44% | 18.83% |
#1
Prev: #1
|
7.0 | no change | no change |
P
S
|
22,970,388 | $604,810,316 | 2022 Q4 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
ANAB
ANAPTYSBIO INC
|
Healthcare | 17.33% | 11.58% |
#2
Prev: #2
|
6.5 | no change | no change |
P
S
|
7,880,094 | $382,026,957 | 2019 Q4 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
JAZZ
JAZZ PHARMACEUT...
|
Healthcare | 13.16% | 10.79% |
#3
1
Prev: #4
|
6.0 | no change | no change |
P
S
|
1,706,469 | $290,099,730 | 2023 Q2 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
CRNX
CRINETICS PHARM...
|
Healthcare | 9.06% | 8.57% |
#4
1
Prev: #5
|
5.1 | no change | no change |
P
S
|
4,288,120 | $199,611,986 | 2020 Q1 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
CNTA
CENTESSA PHARMA...
|
Healthcare | 3.53% | 0.64% |
#5
17
Prev: #22
|
4.9 | 2,565,000 | 466.4% |
P
S
|
3,115,000 | $77,906,150 | 2021 Q2 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
CRSP
CRISPR THERAPEU...
|
Healthcare | 3.31% | 4.32% |
#6
Prev: #6
|
2.3 | no change | no change |
P
S
|
1,389,276 | $72,853,633 | 2018 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
MBX
MBX BIOSCIENCES...
|
Healthcare | 3.04% | 1.78% |
#7
7
Prev: #14
|
2.2 | no change | no change |
P
S
|
2,123,604 | $66,978,470 | 2024 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
IMNM
IMMUNOME INC
|
Healthcare | 2.78% | 2.29% |
#8
4
Prev: #12
|
1.1 | -1,223,825 | -30.0% |
P
S
|
2,855,590 | $61,338,073 | 2023 Q4 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
ORIC
ORIC PHARMACEUT...
|
Healthcare | 2.50% | 3.87% |
#9
1
Prev: #8
|
2.0 | no change | no change |
P
S
|
6,728,116 | $55,035,989 | 2020 Q2 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
GLPG
GALAPAGOS NV
|
Healthcare | 2.47% | 2.77% |
#10
1
Prev: #11
|
2.0 | no change | no change |
P
S
|
1,667,119 | $54,514,791 | 2015 Q4 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
XNCR
XENCOR INC
|
Healthcare | 2.26% | 3.46% |
#11
1
Prev: #10
|
0.9 | -2,893,655 | -47.1% |
P
S
|
3,251,112 | $49,774,525 | 2016 Q2 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
BBOT
BRIDGEBIO ONCOL...
|
Healthcare | 1.60% | 1.57% |
#12
5
Prev: #17
|
1.6 | no change | no change |
P
S
|
2,823,126 | $35,345,538 | 2025 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
ETON
ETON PHARMACEUT...
|
Healthcare | 1.56% | 2.12% |
#13
Prev: #13
|
1.6 | no change | no change |
P
S
|
2,030,544 | $34,336,499 | 2024 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
CGON
CG ONCOLOGY INC
|
Healthcare | 1.45% | — |
#14
Prev: #—
|
4.1 | 772,000 | no change |
NEW
|
772,000 | $32,053,440 | 2025 Q4 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
ZBIO
ZENAS BIOPHARMA...
|
Healthcare | 1.30% | — |
#15
Prev: #—
|
4.0 | 789,500 | no change |
NEW
|
789,500 | $28,666,745 | 2025 Q4 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
NGNE
NEUROGENE INC
|
Healthcare | 1.19% | 1.06% |
#16
2
Prev: #18
|
1.5 | no change | no change |
P
S
|
1,271,342 | $26,189,645 | 2023 Q4 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
GPCR
STRUCTURE THERA...
|
Healthcare | 1.06% | — |
#17
Prev: #—
|
3.9 | 334,380 | no change |
NEW
|
334,380 | $23,256,129 | 2025 Q4 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
PCVX
VAXCYTE INC
|
Healthcare | 0.94% | — |
#18
Prev: #—
|
3.9 | 450,000 | no change |
NEW
|
450,000 | $20,763,000 | 2021 Q4 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
AQST
AQUESTIVE THERA...
|
Healthcare | 0.77% | 0.70% |
#19
1
Prev: #20
|
1.3 | no change | no change |
P
S
|
2,625,000 | $16,957,500 | 2025 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
VYGR
VOYAGER THERAPE...
|
Healthcare | 0.71% | 0.15% |
#20
8
Prev: #28
|
3.3 | 3,332,544 | 497.2% |
P
S
|
4,002,847 | $15,731,189 | 2021 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
CGON
CALL
CG ONCOLOGY INC
|
CALL Option | 0.55% | — |
#21
Prev: #—
|
3.7 | 292,800 | no change |
NEW
|
292,800 | $12,157,056 | 2025 Q4 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
ATRA
ATARA BIOTHERAP...
|
Healthcare | 0.47% | 0.39% |
#22
2
Prev: #24
|
1.2 | no change | no change |
P
S
|
573,183 | $10,368,880 | 2024 Q2 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
MNKD
MANNKIND CORP
|
Healthcare | 0.43% | — |
#23
Prev: #—
|
3.7 | 1,660,000 | no change |
NEW
|
1,660,000 | $9,412,200 | 2025 Q4 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
NUVB/WS
NUVATION BIO IN...
|
Unknown | 0.39% | 0.17% |
#24
3
Prev: #27
|
1.2 | no change | no change |
P
S
|
963,333 | $8,631,464 | 2021 Q1 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
EOLS
EVOLUS INC
|
Healthcare | 0.20% | — |
#25
Prev: #—
|
3.6 | 675,000 | no change |
NEW
|
675,000 | $4,488,750 | 2019 Q4 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
IBIO
IBIO INC
|
Healthcare | 0.20% | — |
#26
Prev: #—
|
3.6 | 2,228,000 | no change |
NEW
|
2,228,000 | $4,300,040 | 2025 Q4 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
MREO
MEREO BIOPHARMA...
|
Healthcare | 0.15% | — |
#27
Prev: #—
|
3.6 | 7,856,466 | no change |
NEW
|
7,856,466 | $3,273,789 | 2025 Q4 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
CAMP
CAMP4 THERAPEUT...
|
Healthcare | 0.09% | — |
#28
Prev: #—
|
3.5 | 325,000 | no change |
NEW
|
325,000 | $1,992,250 | 2025 Q4 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
XNCR
CALL
XENCOR INC
|
CALL Option | 0.05% | — |
#29
Prev: #—
|
3.5 | 67,500 | no change |
NEW
|
67,500 | $1,033,425 | 2016 Q2 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
SRZNW
SURROZEN INC
|
Unknown | 0.00% | 0.04% |
#30
Prev: #30
|
0.0 | -62,221 | -93.3% |
P
S
|
4,444 | $100,434 | 2021 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
CMPS
COMPASS PATHWAY...
|
Healthcare | 0.00% | 0.07% |
Sold All 😨
(Was: #29) |
0.0 | -265,137 | -100.0% |
CLOSED
|
— | $— | 2025 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
PEPG
PEPGEN INC
|
Healthcare | 0.00% | 0.18% |
Sold All 😨
(Was: #26) |
0.0 | -800,000 | -100.0% |
CLOSED
|
— | $— | 2025 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
KURA
KURA ONCOLOGY I...
|
Healthcare | 0.00% | 0.37% |
Sold All 😨
(Was: #25) |
0.0 | -872,500 | -100.0% |
CLOSED
|
— | $— | 2015 Q4 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
PRME
PRIME MEDICINE ...
|
Healthcare | 0.00% | 0.41% |
Sold All 😨
(Was: #23) |
0.0 | -1,543,326 | -100.0% |
CLOSED
|
— | $— | 2022 Q4 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
MTSR
METSERA INC
|
Healthcare | 0.00% | 0.68% |
Sold All 😨
(Was: #21) |
0.0 | -271,529 | -100.0% |
CLOSED
|
— | $— | 2025 Q1 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
ALKS
ALKERMES PLC
|
Healthcare | 0.00% | 0.72% |
Sold All 😨
(Was: #19) |
0.0 | -500,000 | -100.0% |
CLOSED
|
— | $— | 2025 Q2 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
RNA
AVIDITY BIOSCIE...
|
Healthcare | 0.00% | 1.60% |
Sold All 😨
(Was: #16) |
0.0 | -765,000 | -100.0% |
CLOSED
|
— | $— | 2020 Q2 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
MDGL
MADRIGAL PHARMA...
|
Healthcare | 0.00% | 1.65% |
Sold All 😨
(Was: #15) |
0.0 | -75,000 | -100.0% |
CLOSED
|
— | $— | 2017 Q4 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
APLS
APELLIS PHARMAC...
|
Healthcare | 0.00% | 3.74% |
Sold All 😨
(Was: #9) |
0.0 | -3,447,156 | -100.0% |
CLOSED
|
— | $— | 2017 Q4 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
TNGX
TANGO THERAPEUT...
|
Healthcare | 0.00% | 4.29% |
Sold All 😨
(Was: #7) |
0.0 | -10,630,736 | -100.0% |
CLOSED
|
— | $— | 2021 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
QURE
UNIQURE NV
|
Healthcare | 0.00% | 11.17% |
Sold All 😨
(Was: #3) |
0.0 | -3,988,971 | -100.0% |
CLOSED
|
— | $— | 2024 Q4 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) |
Showing 1-41 of 41 holdings