Anaptysbio Inc (ANAB): Hedge Fund Ownership & Smart Money Signals (Q1 2026)

Q: Is it too late to buy Anaptysbio Inc (ANAB) following the 2026 Q1 hedge fund 13F filings?

As of today, ANAB has moved -8.8% since the 2026 Q1 13F filing date (May 15, 2026), compared to +3.2% for the XLV sector ETF — an outperformance of -12.0%. Since the quarter end (March 31, 2026), ANAB gained +55.8% vs +2.1% for XLV. The stock is tracking its sector benchmark closely. The signal remains fresh and the entry point is still near the fund's implied reference.

Anaptysbio Inc (ANAB)

202 + Investors. Track Smart Money conviction in ANAB. See who's accumulating, reducing, or initiating positions.

Smart Money Signals — ANAB

Based on 204 hedge funds · latest filing: 2026 Q1 · updated quarterly

📈

Buying streak — 3 quarters in a row

last 6Q

For 3 consecutive quarters, more hedge funds added ANAB than sold it. That's a consistent pattern of professional buying — not a one-time trade. When institutions keep buying quarter after quarter, it usually means they see a multi-year opportunity, not just a short-term momentum flip.

🏔️

At the ownership peak (100% of max)

100% of all-time peak

204 hedge funds hold ANAB right now — the highest count in 3.0 years. When ownership is this concentrated, any bad news can trigger a chain reaction: one big fund sells, others follow. This is a classic 'crowded trade' — high popularity doesn't equal safety.

🚀

Fast accumulation — +35% more funds vs a year ago

fund count last 6Q

+53 new funds entered over the past year (+35% YoY). That's a rapid rush of institutional money. Fast accumulation often signals a major thesis — but it also means the stock could fall quickly if that thesis breaks.

🟡

Slight buying edge — 53% buying

105 buying94 selling

Last quarter: 105 funds bought or added vs 94 that reduced or exited. It's nearly a 50/50 split — some institutions are convinced, others are taking profits. This mixed picture is normal near price highs.

📈

More new buyers each quarter (+14 vs last Q)

new funds entering per quarter

Funds opening a new ANAB position: 28 → 34 → 35 → 49. A growing influx of new institutional buyers means the asset is still gathering momentum — the consensus hasn't fully saturated yet.

🔒

52% of holders stayed for 2+ years

■ 52% conviction (2yr+) ■ 26% medium ■ 22% new

106 out of 204 hedge funds have held ANAB for over 2 years without selling. Long-term investors are generally harder to shake out during market stress, creating a stable ownership base that limits the risk of sudden capitulation.

📈

Growing discovery — still being found

42 → 28 → 34 → 35 → 49 new funds/Q

New funds entering each quarter: 28 → 34 → 35 → 49. A growing number of institutions are discovering ANAB each quarter. The narrative is still spreading — leaving room for ongoing capital accumulation.

🏛️

Veteran-anchored — 63% veterans vs 25% newcomers

■ 63% veterans ■ 12% 1-2yr ■ 25% new

Entry-cohort mix of 208 holders: 131 (63%) are 2+ year veterans, 26 entered 1–2 years ago, and 51 (25%) joined within the past year. A veteran-weighted cap table skews toward institutional memory over fresh momentum.

✅

Strong quality — 26% AUM from major funds

26% from top-100 AUM funds

41 of 204 holders rank in the top 100 by AUM, accounting for 26% of total institutional value held. A meaningful share of the ownership value comes from the most well-resourced institutions.

4.0

out of 10

Moderate Exit Risk

Exit risk score 4.0/10 — some crowding factors present, but no critical concentration. Watch ownership trend over the next 1–2 quarters for direction.

Methodology note: these Smart Money cards use consecutive 13F disclosure snapshots, not trade-by-trade execution data. "Buying", "selling", "new holders", and "trimmed" refer to quarter-over-quarter changes in reported holders, aggregate shares, or disclosed position values between filings. They are useful for ownership regime analysis and crowding, but they do not imply exact trade timing on the filing date.

Metric	All 13F Filers (2026 Q1)	Prior (2025 Q4)	Change
Funds Holding	202	178	13.48%
13F Shares	29M	30M	-4.91%
Total Value	$1.56B	$1.46B	7.15%
New Positions	48	35	+13
Increased Positions	55	52	+3
Closed Positions	24	22	+2
Reduced Positions	69	65	+4
Total Calls	3	4	-25.0%
Total Puts	1	3	-66.67%
PUT/CALL Ratio	0.33	0.75	Bullish

Metric

All 13F Filers (2026 Q1)

Prior (2025 Q4)

Change

Funds Holding

202

178

13.48%

13F Shares

29M

30M

-4.91%

Total Value

$1.56B

$1.46B

7.15%

New Positions

+13

Increased Positions

Closed Positions

Reduced Positions

Total Calls

-25.0%

Total Puts

-66.67%

PUT/CALL Ratio

0.33

0.75

Bullish

Institutional Holders (2026 Q1)

202 + investors

Explore institutional interest and hedge fund ownership dynamics. Analyze portfolio weights, new positions, and conviction trends in ANAB. Verified SEC 13F-HR filings.

QUARTER:

FILTER:All New Added To Reduced No Change | Overweight >5%

Top 25 ANAB holders by conviction (% of portfolio weight) — 2026 Q1 · Source: SEC Form 13F
#	Investor	% of Portfolio	Shares	Mkt Value
1	EcoR1 Capital, LLC	18.55%	7,880,094	$437.0M
2	Sanofi	9.04%	821,917	$30.4M
3	Palo Alto Investors LP	5.41%	638,161	$35.4M
4	Tang Capital Management LLC	3.75%	1,330,879	$73.8M
5	First Light Asset Management, LLC	2.81%	565,431	$31.4M
6	Affinity Asset Advisors, LLC	2.69%	940,000	$52.1M
7	HighMark Wealth Management LLC	2.12%	94,050	$5.2M
8	Apis Capital Advisors, LLC	2.04%	238,000	$13.2M
9	Synergy Asset Management, LLC	1.87%	317,106	$17.6M
10	683 Capital Management, LLC	1.81%	625,000	$34.7M
11	Ground Swell Capital, LLC	0.83%	7,610	$422K
12	Sofinnova Investments, Inc.	0.52%	248,253	$13.8M
13	Moody Aldrich Partners LLC	0.39%	39,455	$2.2M
14	Bayforest Capital Ltd	0.33%	5,244	$291K
15	Oxford Asset Management LLP	0.30%	12,676	$703K
16	DCF Advisers, LLC	0.28%	18,775	$1.0M
17	Hussman Strategic Advisors, INC.	0.25%	21,000	$1.2M
18	Latash Investments, LLC	0.19%	4,393	$244K
19	Granahan Investment Management, LLC	0.18%	66,182	$3.7M
20	Headlands Technologies LLC	0.16%	24,558	$1.4M
21	Fmb Wealth Management	0.13%	5,592	$310K
22	Tema Etfs LLC	0.12%	31,069	$1.7M
23	Duncan Williams Asset Management, LLC	0.10%	6,525	$362K
24	Virtus Investment Advisers, LLC	0.09%	6,067	$336K
25	Brookwood Investment Group LLC	0.09%	13,362	$741K

Investor	Ownership History	% of Portfolio	Prev %	Rank	Conviction	Avg Buy Price	13F Score™ 3Y / 7Y	Sell Timing	Shares	Mkt Value	Change	Change %	Source	Quarter	Filed

Frequently Asked Questions — Anaptysbio Inc (ANAB)

What does the Smart Money Trend signal show for ANAB?

Buying streak — 3 quarters in a row: For 3 consecutive quarters, more hedge funds added ANAB than sold it. That's a consistent pattern of professional buying — not a one-time trade. When institutions keep buying quarter after quarter, it usually means they see a multi-year opportunity, not just a short-term momentum flip.

What is the institutional breadth score for ANAB?

Slight buying edge — 53% buying: Last quarter: 105 funds bought or added vs 94 that reduced or exited. It's nearly a 50/50 split — some institutions are convinced, others are taking profits. This mixed picture is normal near price highs.

What is the fund quality score for ANAB holders?

Strong quality — 26% AUM from major funds: 41 of 204 holders rank in the top 100 by AUM, accounting for 26% of total institutional value held. A meaningful share of the ownership value comes from the most well-resourced institutions.

How long have hedge funds held ANAB?

52% of holders stayed for 2+ years: 106 out of 204 hedge funds have held ANAB for over 2 years without selling. Long-term investors are generally harder to shake out during market stress, creating a stable ownership base that limits the risk of sudden capitulation.

Is it too late to buy Anaptysbio Inc (ANAB) following the 2026 Q1 hedge fund 13F filings?

As of today, ANAB has moved -8.8% since the 2026 Q1 13F filing date (May 15, 2026), compared to +3.2% for the XLV sector ETF — an outperformance of -12.0%. Since the quarter end (March 31, 2026), ANAB has gained +55.8% vs +2.1% for XLV. The stock is tracking its sector benchmark closely. The signal remains fresh and the entry point is still near the fund's implied reference.

Where does this institutional ownership data come from?

All holdings data is sourced from SEC Form 13F filings, which institutional investment managers with over $100 million in assets are required to submit quarterly. Data is parsed directly from SEC EDGAR.

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Anaptysbio Inc (ANAB)

Smart Money Signals — ANAB

Buying streak — 3 quarters in a row

At the ownership peak (100% of max)

Fast accumulation — +35% more funds vs a year ago

Slight buying edge — 53% buying

More new buyers each quarter (+14 vs last Q)

52% of holders stayed for 2+ years

Growing discovery — still being found

Veteran-anchored — 63% veterans vs 25% newcomers

Strong quality — 26% AUM from major funds

Institutional Sentiment Summary — ANAB

Hedge Fund Ownership: ANAB

Market Analysis: ANAB

Analyst Price Targets

Analyst Recommendations

Stock Performance

Company Profile: ANAB

Is It Too Late to Buy Anaptysbio Inc (ANAB) Based on Hedge Fund 13F Filings?

Hedge Fund Positioning: ANAB

Statistics: ANAB

Valuation Measures Data as of: --

Financial Highlights

Institutional Holders (2026 Q1)

Frequently Asked Questions — Anaptysbio Inc (ANAB)

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