Spruce Street Capital LP

All Holdings — 2025 Q4

AI Portfolio Summary
In 2025 Q4, Spruce Street Capital LP maintained a portfolio of 27 distinct positions. The most significant new addition to the portfolio was CIDARA THERAPEUTICS , which now represents 16.95% of the total fund value.
PCA Score Concentration Risk
Risk ENB
Total Positions
27
Quarter
2025 Q4
Top Holding
CDTX (17.0%)
Top 10 Concentration
70.8%
Turnover Rate
23.4%
Sector HHI
0.18
Items per page:
Showing 1-27 of 27
Stock History Sector / Type Port % Prev % Rank / Prev Conviction Change % Change Influence Shares Mkt Value Avg Cost Price Held 1st Owned Source Source Date Date Reported
CDTX
CIDARA THERAPEU...
Unknown 16.95% #1
Prev: #—
9.5 232,269 no change
NEW
232,269 $51,305,899 2025 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
RLAY
RELAY THERAPEUT...
Healthcare 8.34% #2
Prev: #—
8.3 2,984,125 no change
NEW
2,984,125 $25,245,698 2025 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
LBRX
LB PHARMACEUTIC...
Healthcare 7.40% #3
Prev: #—
7.5 1,005,593 no change
NEW
1,005,593 $22,384,500 2025 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
RLMD
RELMADA THERAPE...
Healthcare 6.52% #4
Prev: #—
6.6 4,086,181 no change
NEW
4,086,181 $19,736,254 2025 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
PCVX
VAXCYTE INC
Healthcare 6.10% #5
Prev: #—
6.4 400,360 no change
NEW
400,360 $18,472,610 2025 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
KNSA
KINIKSA PHARMAC...
Healthcare 5.93% #6
Prev: #—
5.9 434,982 no change
NEW
434,982 $17,943,008 2025 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
EYPT
EYEPOINT INC
Healthcare 5.93% #7
Prev: #—
5.9 981,543 no change
NEW
981,543 $17,932,791 2025 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
SVRA
SAVARA INC
Healthcare 4.80% #8
Prev: #—
5.4 2,411,093 no change
NEW
2,411,093 $14,538,891 2025 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
ERAS
ERASCA INC
Healthcare 4.78% #9
Prev: #—
5.4 3,889,632 no change
NEW
3,889,632 $14,469,431 2025 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
DNTH
DIANTHUS THERAP...
Healthcare 4.05% #10
Prev: #—
5.1 297,437 no change
NEW
297,437 $12,257,379 2025 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
SRZN
SURROZEN INC
Healthcare 3.23% #11
Prev: #—
4.8 432,040 no change
NEW
432,040 $9,764,104 2025 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
OCUL
OCULAR THERAPEU...
Healthcare 3.14% #12
Prev: #—
4.8 783,999 no change
NEW
783,999 $9,517,748 2025 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
SABS
SAB BIOTHERAPEU...
Healthcare 2.72% #13
Prev: #—
4.6 2,198,502 no change
NEW
2,198,502 $8,222,397 2025 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
IKT
INHIBIKASE THER...
Healthcare 2.43% #14
Prev: #—
4.5 3,581,603 no change
NEW
3,581,603 $7,342,286 2025 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
ELVN
ENLIVEN THERAPE...
Healthcare 2.27% #15
Prev: #—
4.4 446,084 no change
NEW
446,084 $6,869,694 2025 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
NERV
MINERVA NEUROSC...
Healthcare 2.20% #16
Prev: #—
4.4 1,655,500 no change
NEW
1,655,500 $6,655,110 2025 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
ABVX
ABIVAX SA
Healthcare 2.19% #17
Prev: #—
4.4 49,119 no change
NEW
49,119 $6,623,943 2025 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
CYBN
CYBIN INC
Unknown 2.08% #18
Prev: #—
4.3 770,000 no change
NEW
770,000 $6,298,600 2025 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
KALV
KALVISTA PHARMA...
Healthcare 2.07% #19
Prev: #—
4.3 387,968 no change
NEW
387,968 $6,265,683 2025 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
ENTA
ENANTA PHARMACE...
Healthcare 2.03% #20
Prev: #—
4.3 389,687 no change
NEW
389,687 $6,145,364 2025 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
ANRO
ALTO NEUROSCIEN...
Healthcare 1.31% #21
Prev: #—
4.0 222,844 no change
NEW
222,844 $3,966,623 2025 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
LONA
ATHIRA PHARMA I...
Healthcare 0.98% #22
Prev: #—
3.9 393,701 no change
NEW
393,701 $2,980,317 2025 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
CNTA
CENTESSA PHARMA...
Healthcare 0.64% #23
Prev: #—
3.8 77,997 no change
NEW
77,997 $1,950,705 2025 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
ALEC
ALECTOR INC
Healthcare 0.58% #24
Prev: #—
3.7 1,117,986 no change
NEW
1,117,986 $1,744,058 2025 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
LXEO
LEXEO THERAPEUT...
Healthcare 0.57% #25
Prev: #—
3.7 175,000 no change
NEW
175,000 $1,737,750 2025 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
IPSC
CENTURY THERAPE...
Healthcare 0.47% #26
Prev: #—
3.7 1,421,532 no change
NEW
1,421,532 $1,414,140 2025 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
STRO
SUTRO BIOPHARMA...
Healthcare 0.29% #27
Prev: #—
3.6 75,594 no change
NEW
75,594 $874,623 2025 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
Showing 1-27 of 27 holdings

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