AI Portfolio Summary
In 2025 Q4, SPHERA FUNDS MANAGEMENT LTD. maintained a portfolio of 139 distinct positions. The most significant new addition to the portfolio was BIOMARIN PHARMACEUTI, which now represents 1.69% of the total fund value. They heavily accumulated shares in BIOGEN INC, increasing their position by 14.5%. Conversely, SPHERA FUNDS MANAGEMENT LTD. completely exited their position in NICE LTD.
Total Positions
139
Quarter
2025 Q4
Top Holding
TEVA (6.8%)
Top 10 Concentration
31.6%
Turnover Rate
23.4%
Sector HHI
0.18
Items per page:
1-25 of 139
| Stock | History | Sector / Type | Port % | Prev % | Rank / Prev | Conviction | Change | % Change | Influence | Shares | Mkt Value | Avg Cost | Price Held | 1st Owned | Source | Source Date | Date Reported |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
TEVA
TEVA PHARMACEUT...
|
Healthcare | 6.78% | 6.42% |
#1
Prev: #1
|
4.7 | -383,500 | -25.4% |
P
S
|
1,123,525 | $35,065,215 | 2013 Q4 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
BIIB
BIOGEN INC
|
Healthcare | 3.22% | 2.44% |
#2
5
Prev: #7
|
4.8 | 12,000 | 14.5% |
P
S
|
94,738 | $16,672,941 | 2013 Q4 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
MLYS
MINERALYS THERA...
|
Healthcare | 3.15% | 1.76% |
#3
10
Prev: #13
|
5.3 | 229,093 | 104.2% |
P
S
|
449,003 | $16,294,319 | 2023 Q1 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
SNDX
SYNDAX PHARMACE...
|
Healthcare | 3.10% | 1.26% |
#4
16
Prev: #20
|
4.7 | 374,847 | 96.7% |
P
S
|
762,563 | $16,021,449 | 2016 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
NVMI
NOVA LTD
|
Technology | 3.04% | 2.96% |
#5
Prev: #5
|
3.7 | 3,950 | 9.0% |
P
S
|
47,846 | $15,712,148 | 2014 Q1 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
TSEM
TOWER SEMICONDU...
|
Technology | 2.78% | 4.76% |
#6
3
Prev: #3
|
1.1 | -189,289 | -60.7% |
P
S
|
122,513 | $14,385,476 | 2016 Q4 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
COGT
COGENT BIOSCIEN...
|
Healthcare | 2.60% | 0.30% |
#7
77
Prev: #84
|
4.0 | 279,974 | 284.2% |
P
S
|
378,500 | $13,444,320 | 2020 Q4 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
AZN
ASTRAZENECA PLC
|
Healthcare | 2.40% | 2.19% |
#8
1
Prev: #9
|
2.0 | no change | no change |
P
S
|
135,060 | $12,416,066 | 2015 Q1 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
PRAX
CALL
PRAXIS PRECISIO...
|
CALL Option | 2.28% | 0.56% |
#9
53
Prev: #62
|
0.9 | -10,000 | -20.0% |
P
S
|
40,000 | $11,789,600 | 2024 Q1 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
SNY
SANOFI SA
|
Healthcare | 2.24% | 2.19% |
#10
Prev: #10
|
2.9 | 20,000 | 9.1% |
P
S
|
239,515 | $11,606,897 | 2014 Q1 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
LLY
ELI LILLY & CO
|
Healthcare | 1.88% | 1.62% |
#11
4
Prev: #15
|
1.3 | -1,000 | -10.0% |
P
S
|
9,040 | $9,715,107 | 2014 Q1 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
FOLD
AMICUS THERAPEU...
|
Healthcare | 1.81% | 1.65% |
#12
2
Prev: #14
|
0.7 | -332,765 | -33.6% |
P
S
|
658,377 | $9,375,288 | 2014 Q4 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
IMTX
IMMATICS N.V
|
Healthcare | 1.75% | 1.05% |
#13
19
Prev: #32
|
3.2 | 278,000 | 47.7% |
P
S
|
861,105 | $9,041,603 | 2020 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
BMRN
BIOMARIN PHARMA...
|
Healthcare | 1.69% | — |
#14
Prev: #—
|
4.2 | 147,000 | no change |
NEW
|
147,000 | $8,736,210 | 2014 Q2 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
XBI
PUT
SPDR SERIES TRU...
|
PUT Option | 1.65% | — |
#15
Prev: #—
|
4.2 | 70,000 | no change |
NEW
|
70,000 | $8,535,100 | 2017 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
BBIO
BRIDGEBIO PHARM...
|
Healthcare | 1.59% | 0.45% |
#16
56
Prev: #72
|
3.6 | 67,000 | 164.4% |
P
S
|
107,746 | $8,241,492 | 2020 Q4 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
ORIC
ORIC PHARMACEUT...
|
Healthcare | 1.59% | 1.09% |
#17
14
Prev: #31
|
3.6 | 572,685 | 132.7% |
P
S
|
1,004,378 | $8,215,812 | 2020 Q4 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
RARE
CALL
ULTRAGENYX PHAR...
|
CALL Option | 1.56% | — |
#18
Prev: #—
|
4.1 | 350,000 | no change |
NEW
|
350,000 | $8,050,000 | 2015 Q2 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
DYN
DYNE THERAPEUTI...
|
Healthcare | 1.49% | 1.14% |
#19
7
Prev: #26
|
1.1 | -33,624 | -7.9% |
P
S
|
392,894 | $7,685,007 | 2020 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
TRVI
TREVI THERAPEUT...
|
Healthcare | 1.45% | 1.24% |
#20
1
Prev: #21
|
1.1 | -45,423 | -7.1% |
P
S
|
598,534 | $7,493,646 | 2025 Q2 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
JNJ
JOHNSON & JOHNS...
|
Healthcare | 1.43% | 1.60% |
#21
5
Prev: #16
|
1.1 | -5,000 | -12.2% |
P
S
|
35,831 | $7,415,225 | 2013 Q4 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
SVRA
SAVARA INC
|
Healthcare | 1.37% | 1.02% |
#22
12
Prev: #34
|
1.0 | -172,169 | -12.8% |
P
S
|
1,178,164 | $7,104,329 | 2017 Q2 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
SRRK
SCHOLAR ROCK HL...
|
Healthcare | 1.35% | — |
#23
Prev: #—
|
4.0 | 158,265 | no change |
NEW
|
158,265 | $6,971,573 | 2018 Q2 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
WVE
WAVE LIFE SCIEN...
|
Healthcare | 1.34% | 0.08% |
#24
85
Prev: #109
|
3.5 | 358,166 | 716.3% |
P
S
|
408,166 | $6,938,822 | 2019 Q2 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
RARE
ULTRAGENYX PHAR...
|
Healthcare | 1.34% | 2.24% |
#25
17
Prev: #8
|
1.0 | -51,935 | -14.7% |
P
S
|
300,623 | $6,914,329 | 2015 Q2 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
NICE
NICE LTD
|
Technology | 0.00% | 4.81% |
Sold All 😨
(Was: #2) |
0.0 | -157,400 | -100.0% |
CLOSED
|
— | $— | 2014 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
MRUS
CALL
MERUS N V
|
CALL Option | 0.00% | 2.98% |
Sold All 😨
(Was: #4) |
0.0 | -150,000 | -100.0% |
CLOSED
|
— | $— | 2021 Q1 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
QQQ
INVESCO QQQ TR
|
ETF | 0.00% | 2.91% |
Sold All 😨
(Was: #6) |
0.0 | -22,960 | -100.0% |
CLOSED
|
— | $— | 2013 Q4 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
CDTX
CALL
CIDARA THERAPEU...
|
CALL Option | 0.00% | 2.02% |
Sold All 😨
(Was: #11) |
0.0 | -100,000 | -100.0% |
CLOSED
|
— | $— | 2025 Q1 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
CDTX
CIDARA THERAPEU...
|
Healthcare | 0.00% | 1.53% |
Sold All 😨
(Was: #17) |
0.0 | -75,743 | -100.0% |
CLOSED
|
— | $— | 2025 Q1 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
BBIO
CALL
BRIDGEBIO PHARM...
|
CALL Option | 0.00% | 1.42% |
Sold All 😨
(Was: #19) |
0.0 | -130,000 | -100.0% |
CLOSED
|
— | $— | 2020 Q4 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
CLBT
CELLEBRITE DI L...
|
Technology | 0.00% | 1.17% |
Sold All 😨
(Was: #24) |
0.0 | -298,948 | -100.0% |
CLOSED
|
— | $— | 2025 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
RAPP
RAPPORT THERAPE...
|
Healthcare | 0.00% | 0.99% |
Sold All 😨
(Was: #36) |
0.0 | -157,533 | -100.0% |
CLOSED
|
— | $— | 2025 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
QURE
PUT
UNIQURE NV
|
PUT Option | 0.00% | 0.92% |
Sold All 😨
(Was: #37) |
0.0 | -75,000 | -100.0% |
CLOSED
|
— | $— | 2014 Q1 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
IMVT
IMMUNOVANT INC
|
Healthcare | 0.00% | 0.87% |
Sold All 😨
(Was: #40) |
0.0 | -256,743 | -100.0% |
CLOSED
|
— | $— | 2019 Q4 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
ENGN
ENGENE HOLDINGS...
|
Healthcare | 0.00% | 0.73% |
Sold All 😨
(Was: #43) |
0.0 | -504,409 | -100.0% |
CLOSED
|
— | $— | 2024 Q4 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
RZLT
REZOLUTE INC
|
Healthcare | 0.00% | 0.72% |
Sold All 😨
(Was: #45) |
0.0 | -363,947 | -100.0% |
CLOSED
|
— | $— | 2022 Q2 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
PRAX
PRAXIS PRECISIO...
|
Healthcare | 0.00% | 0.65% |
Sold All 😨
(Was: #50) |
0.0 | -57,901 | -100.0% |
CLOSED
|
— | $— | 2024 Q1 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
AMZN
AMAZON COM INC
|
Consumer Cyclical | 0.00% | 0.64% |
Sold All 😨
(Was: #52) |
0.0 | -13,760 | -100.0% |
CLOSED
|
— | $— | 2019 Q1 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
SRPT
CALL
SAREPTA THERAPE...
|
CALL Option | 0.00% | 0.61% |
Sold All 😨
(Was: #55) |
0.0 | -150,000 | -100.0% |
CLOSED
|
— | $— | 2013 Q4 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
META
META PLATFORMS ...
|
Communication Services | 0.00% | 0.61% |
Sold All 😨
(Was: #56) |
0.0 | -3,924 | -100.0% |
CLOSED
|
— | $— | 2016 Q4 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
ORA
ORMAT TECHNOLOG...
|
Utilities | 0.00% | 0.59% |
Sold All 😨
(Was: #59) |
0.0 | -29,000 | -100.0% |
CLOSED
|
— | $— | 2014 Q1 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
IDYA
IDEAYA BIOSCIEN...
|
Healthcare | 0.00% | 0.57% |
Sold All 😨
(Was: #60) |
0.0 | -100,000 | -100.0% |
CLOSED
|
— | $— | 2021 Q1 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
TVTX
CALL
TRAVERE THERAPE...
|
CALL Option | 0.00% | 0.51% |
Sold All 😨
(Was: #64) |
0.0 | -101,800 | -100.0% |
CLOSED
|
— | $— | 2023 Q1 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
ROIV
CALL
ROIVANT SCIENCE...
|
CALL Option | 0.00% | 0.48% |
Sold All 😨
(Was: #65) |
0.0 | -151,600 | -100.0% |
CLOSED
|
— | $— | 2025 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
CEVA
CEVA INC
|
Technology | 0.00% | 0.45% |
Sold All 😨
(Was: #71) |
0.0 | -81,085 | -100.0% |
CLOSED
|
— | $— | 2025 Q1 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
TECX
TECTONIC THERAP...
|
Healthcare | 0.00% | 0.38% |
Sold All 😨
(Was: #76) |
0.0 | -115,908 | -100.0% |
CLOSED
|
— | $— | 2025 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
PCVX
VAXCYTE INC
|
Healthcare | 0.00% | 0.38% |
Sold All 😨
(Was: #77) |
0.0 | -50,000 | -100.0% |
CLOSED
|
— | $— | 2023 Q1 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
IMNM
IMMUNOME INC
|
Healthcare | 0.00% | 0.36% |
Sold All 😨
(Was: #79) |
0.0 | -147,200 | -100.0% |
CLOSED
|
— | $— | 2025 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
MIST
MILESTONE PHARM...
|
Healthcare | 0.00% | 0.35% |
Sold All 😨
(Was: #80) |
0.0 | -820,000 | -100.0% |
CLOSED
|
— | $— | 2020 Q1 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
QURE
UNIQURE NV
|
Healthcare | 0.00% | 0.31% |
Sold All 😨
(Was: #82) |
0.0 | -24,900 | -100.0% |
CLOSED
|
— | $— | 2014 Q1 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
GPCR
CALL
STRUCTURE THERA...
|
CALL Option | 0.00% | 0.30% |
Sold All 😨
(Was: #85) |
0.0 | -50,000 | -100.0% |
CLOSED
|
— | $— | 2025 Q1 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
BHVN
BIOHAVEN LTD
|
Healthcare | 0.00% | 0.29% |
Sold All 😨
(Was: #88) |
0.0 | -91,155 | -100.0% |
CLOSED
|
— | $— | 2018 Q1 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
BCAX
BICARA THERAPEU...
|
Healthcare | 0.00% | 0.29% |
Sold All 😨
(Was: #89) |
0.0 | -85,747 | -100.0% |
CLOSED
|
— | $— | 2025 Q2 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
TRVI
CALL
TREVI THERAPEUT...
|
CALL Option | 0.00% | 0.25% |
Sold All 😨
(Was: #93) |
0.0 | -129,200 | -100.0% |
CLOSED
|
— | $— | 2025 Q2 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
SABS
SAB BIOTHERAPEU...
|
Healthcare | 0.00% | 0.24% |
Sold All 😨
(Was: #94) |
0.0 | -566,395 | -100.0% |
CLOSED
|
— | $— | 2025 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
LRMR
LARIMAR THERAPE...
|
Healthcare | 0.00% | 0.18% |
Sold All 😨
(Was: #98) |
0.0 | -260,385 | -100.0% |
CLOSED
|
— | $— | 2020 Q2 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
ROIV
ROIVANT SCIENCE...
|
Healthcare | 0.00% | 0.14% |
Sold All 😨
(Was: #102) |
0.0 | -42,571 | -100.0% |
CLOSED
|
— | $— | 2025 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
ETNB
89BIO INC
|
Unknown | 0.00% | 0.12% |
Sold All 😨
(Was: #103) |
0.0 | -39,675 | -100.0% |
CLOSED
|
— | $— | 2020 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
ELDN
PUT
ELEDON PHARMACE...
|
PUT Option | 0.00% | 0.11% |
Sold All 😨
(Was: #104) |
0.0 | -200,000 | -100.0% |
CLOSED
|
— | $— | 2024 Q2 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
MLTX
MOONLAKE IMMUNO...
|
Healthcare | 0.00% | 0.11% |
Sold All 😨
(Was: #105) |
0.0 | -71,010 | -100.0% |
CLOSED
|
— | $— | 2025 Q2 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
CMMB
CHEMOMAB THERAP...
|
Healthcare | 0.00% | 0.10% |
Sold All 😨
(Was: #106) |
0.0 | -179,425 | -100.0% |
CLOSED
|
— | $— | 2024 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
ARWR
ARROWHEAD PHARM...
|
Healthcare | 0.00% | 0.09% |
Sold All 😨
(Was: #107) |
0.0 | -12,496 | -100.0% |
CLOSED
|
— | $— | 2015 Q2 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
DSGN
DESIGN THERAPEU...
|
Healthcare | 0.00% | 0.03% |
Sold All 😨
(Was: #111) |
0.0 | -21,918 | -100.0% |
CLOSED
|
— | $— | 2025 Q3 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) | |||
|
MLTX
CALL
MOONLAKE IMMUNO...
|
CALL Option | 0.00% | 0.02% |
Sold All 😨
(Was: #113) |
0.0 | -10,000 | -100.0% |
CLOSED
|
— | $— | 2025 Q2 | 13F Filing | 2025-12-31 | 2026-02-14 (Est.) |
Showing 1-25 of 139 holdings