2026 Q1 Portfolio Activity
In 2026 Q1, SPHERA FUNDS MANAGEMENT LTD. maintained a portfolio of 121 distinct positions. The most significant new addition was ASTRAZENECA PLC, now representing 1.96% of the total fund value. They heavily accumulated shares in MINERALYS THERAPEUTICS INC, increasing the position by 198.4%. Conversely, SPHERA FUNDS MANAGEMENT LTD. completely exited their position in ASTRAZENECA PLC.
Position History
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Total Positions
121
Quarter
2026 Q1
Top Holding
MLYS (5.8%)
Top 10 Concentration
36.7%
Turnover Rate
23.4%
Sector HHI
0.18
Items per page:
Showing 1-50 of 121
SPHERA FUNDS MANAGEMENT LTD. Full Holdings List — 2026 Q1
| Stock | History | Sector / Type | Port % | Prev % | Rank / Prev | Conviction | Change | % Change | Influence | Shares | Mkt Value | Avg Cost | Price Held | 1st Owned | Source | Source Date | Date Reported | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
MLYS
MINERALYS THERA...
|
Healthcare | 5.76% | 3.15% |
#1
2
Prev: #3
|
7.3 |
—
|
890,968 | 198.4% |
P
S
|
1,339,971 | $36,299,814 |
$28.97
-9.2%
|
2023 Q1 | 13F Filing | 2026-03-31 | 2026-05-15 | ||
|
TEVA
TEVA PHARMACEUT...
|
Healthcare | 5.44% | 6.78% |
#2
1
Prev: #1
|
4.2 |
—
|
13,450 | 1.2% |
P
S
|
1,136,975 | $34,245,687 | 2013 Q4 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
TSEM
TOWER SEMICONDU...
|
Technology | 4.06% | 2.78% |
#3
3
Prev: #6
|
4.6 |
—
|
23,222 | 19.0% |
P
S
|
145,735 | $25,573,578 | 2016 Q4 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
XBI
PUT
SPDR SERIES TRU...
|
PUT Option | 4.06% | 1.65% |
#4
11
Prev: #15
|
5.1 |
—
|
130,000 | 185.7% |
P
S
|
200,000 | $25,546,001 | 2017 Q3 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
NVMI
NOVA LTD
|
Technology | 3.68% | 3.04% |
#5
Prev: #5
|
4.0 |
—
|
5,520 | 11.5% |
P
S
|
53,366 | $23,175,786 | 2014 Q1 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
BBIO
BRIDGEBIO PHARM...
|
Healthcare | 2.89% | 1.59% |
#6
10
Prev: #16
|
4.2 |
—
|
137,500 | 127.6% |
P
S
|
245,246 | $18,211,968 | 2020 Q4 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
CYTK
CALL
CYTOKINETICS IN...
|
CALL Option | 2.71% | — |
#7
Prev: #—
|
4.6 |
—
|
259,300 | — |
NEW
|
259,300 | $17,090,464 | 2013 Q4 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
BIIB
BIOGEN INC
|
Healthcare | 2.69% | 3.22% |
#8
6
Prev: #2
|
1.6 |
—
|
-2,212 | -2.3% |
P
S
|
92,526 | $16,962,792 | 2013 Q4 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
RARE
ULTRAGENYX PHAR...
|
Healthcare | 2.69% | 1.34% |
#9
16
Prev: #25
|
4.1 |
—
|
508,710 | 169.2% |
P
S
|
809,333 | $16,955,526 | 2015 Q2 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
SNDX
SYNDAX PHARMACE...
|
Healthcare | 2.69% | 3.10% |
#10
6
Prev: #4
|
1.6 |
—
|
-38,000 | -5.0% |
P
S
|
724,563 | $16,925,792 | 2016 Q3 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
COGT
COGENT BIOSCIEN...
|
Healthcare | 2.54% | 2.60% |
#11
4
Prev: #7
|
3.0 |
—
|
37,840 | 10.0% |
P
S
|
416,340 | $16,024,927 | 2020 Q4 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
SNY
SANOFI SA
|
Healthcare | 2.06% | 2.24% |
#12
2
Prev: #10
|
2.8 |
—
|
30,000 | 12.5% |
P
S
|
269,515 | $12,985,233 | 2014 Q1 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
AZNCF
ASTRAZENECA PLC
|
Unknown | 1.96% | — |
#13
Prev: #—
|
4.3 |
—
|
62,530 | — |
NEW
|
62,530 | $12,332,167 | 2026 Q1 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
FOLD
AMICUS THERAPEU...
|
Healthcare | 1.39% | 1.81% |
#14
2
Prev: #12
|
1.1 |
—
|
-55,000 | -8.4% |
P
S
|
603,377 | $8,724,831 | 2014 Q4 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
CLBT
CELLEBRITE DI L...
|
Technology | 1.38% | — |
#15
Prev: #—
|
4.1 |
—
|
631,521 | — |
NEW
|
631,521 | $8,702,359 | 2025 Q3 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
APLS
APELLIS PHARMAC...
|
Healthcare | 1.37% | 1.22% |
#16
15
Prev: #31
|
1.0 |
—
|
-36,047 | -14.4% |
P
S
|
214,914 | $8,645,990 | 2018 Q2 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
PANW
PALO ALTO NETWO...
|
Technology | 1.34% | — |
#17
Prev: #—
|
4.0 |
—
|
52,800 | — |
NEW
|
52,800 | $8,464,896 | 2015 Q3 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
LLY
ELI LILLY & CO
|
Healthcare | 1.32% | 1.88% |
#18
7
Prev: #11
|
1.5 |
—
|
no change | no change |
P
S
|
9,040 | $8,314,721 | 2014 Q1 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
BCRX
BIOCRYST PHARMA...
|
Healthcare | 1.31% | 1.26% |
#19
9
Prev: #28
|
1.0 |
—
|
28,575 | 3.4% |
P
S
|
866,464 | $8,248,737 | 2025 Q4 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
CAMT
CAMTEK LTD
|
Technology | 1.28% | 0.81% |
#20
29
Prev: #49
|
3.0 |
—
|
13,522 | 34.2% |
P
S
|
53,020 | $8,038,362 | 2017 Q2 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
BMRN
BIOMARIN PHARMA...
|
Healthcare | 1.26% | 1.69% |
#21
7
Prev: #14
|
1.0 |
—
|
-7,100 | -4.8% |
P
S
|
139,900 | $7,902,951 | 2014 Q2 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
CLDX
CELLDEX THERAPE...
|
Healthcare | 1.23% | 1.26% |
#22
7
Prev: #29
|
1.0 |
—
|
3,811 | 1.6% |
P
S
|
243,575 | $7,726,199 | 2020 Q3 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
ORA
ORMAT TECHNOLOG...
|
Utilities | 1.21% | — |
#23
Prev: #—
|
4.0 |
—
|
68,250 | — |
NEW
|
68,250 | $7,638,540 | 2014 Q1 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
XENE
XENON PHARMACEU...
|
Healthcare | 1.17% | — |
#24
Prev: #—
|
4.0 |
—
|
127,000 | — |
NEW
|
127,000 | $7,385,050 | 2016 Q3 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
SLNO
SOLENO THERAPEU...
|
Healthcare | 1.15% | 1.22% |
#25
5
Prev: #30
|
3.5 |
—
|
79,967 | 58.7% |
P
S
|
216,281 | $7,241,088 | 2020 Q2 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
TNGX
TANGO THERAPEUT...
|
Healthcare | 1.14% | 0.93% |
#26
19
Prev: #45
|
0.5 |
—
|
-201,000 | -36.9% |
P
S
|
343,563 | $7,187,338 | 2024 Q3 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
JNJ
JOHNSON & JOHNS...
|
Healthcare | 1.12% | 1.43% |
#27
6
Prev: #21
|
0.9 |
—
|
-7,000 | -19.5% |
P
S
|
28,831 | $7,047,450 | 2013 Q4 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
N/A
SOLAREDGE TECHN...
|
|
Bond/Debt | 1.10% | 0.91% |
#28
18
Prev: #46
|
1.4 |
—
|
no change | no change |
P
S
|
4,000,000 | $6,909,620 | — | 13F Filing | 2026-03-31 | 2026-05-15 | ||
|
IMTX
IMMATICS N.V
|
Healthcare | 1.09% | 1.75% |
#29
16
Prev: #13
|
0.9 |
—
|
-165,000 | -19.2% |
P
S
|
696,105 | $6,849,673 | 2020 Q3 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
TRVI
TREVI THERAPEUT...
|
Healthcare | 1.09% | 1.45% |
#30
10
Prev: #20
|
0.9 |
—
|
-24,505 | -4.1% |
P
S
|
574,029 | $6,848,166 | 2025 Q2 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
ORIC
ORIC PHARMACEUT...
|
Healthcare | 1.08% | 1.59% |
#31
14
Prev: #17
|
0.4 |
—
|
-466,750 | -46.5% |
P
S
|
537,628 | $6,811,747 | 2020 Q4 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
MAZE
MAZE THERAPEUTI...
|
Healthcare | 1.08% | 0.58% |
#32
31
Prev: #63
|
3.4 |
—
|
155,500 | 216.4% |
P
S
|
227,343 | $6,786,189 | 2025 Q1 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
GSK
GSK PLC
|
Healthcare | 1.07% | 1.16% |
#33
Prev: #33
|
1.4 |
—
|
no change | no change |
P
S
|
122,000 | $6,733,180 | 2013 Q4 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
AMZN
AMAZON COM INC
|
Consumer Cyclical | 1.06% | — |
#34
Prev: #—
|
3.9 |
—
|
31,940 | — |
NEW
|
31,940 | $6,652,144 | 2019 Q1 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
ABBV
ABBVIE INC
|
Healthcare | 1.05% | 1.12% |
#35
2
Prev: #37
|
2.4 |
—
|
5,000 | 19.8% |
P
S
|
30,256 | $6,580,377 | 2014 Q3 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
AAOI
APPLIED OPTOELE...
|
Technology | 0.99% | — |
#36
Prev: #—
|
3.9 |
—
|
73,400 | — |
NEW
|
73,400 | $6,208,906 | 2026 Q1 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
ELVN
ENLIVEN THERAPE...
|
Healthcare | 0.95% | 0.68% |
#37
18
Prev: #55
|
0.4 |
—
|
-73,500 | -32.4% |
P
S
|
153,265 | $6,007,988 | 2025 Q1 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
MRK
MERCK & CO INC
|
Healthcare | 0.93% | 0.99% |
#38
3
Prev: #41
|
1.4 |
—
|
no change | no change |
P
S
|
48,600 | $5,846,094 | 2013 Q4 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
VOR
VOR BIOPHARMA I...
|
Healthcare | 0.91% | 1.04% |
#39
1
Prev: #40
|
0.4 |
—
|
-88,500 | -21.6% |
P
S
|
321,917 | $5,742,999 | 2025 Q4 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
ACAD
ACADIA PHARMACE...
|
Healthcare | 0.91% | 1.10% |
#40
1
Prev: #39
|
2.9 |
—
|
44,000 | 20.7% |
P
S
|
256,202 | $5,703,057 | 2015 Q4 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
NVS
NOVARTIS AG
|
Healthcare | 0.90% | 0.99% |
#41
1
Prev: #42
|
1.4 |
—
|
no change | no change |
P
S
|
37,000 | $5,651,750 | 2013 Q4 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
ELDN
ELEDON PHARMACE...
|
Healthcare | 0.87% | 0.62% |
#42
16
Prev: #58
|
0.8 |
—
|
-360,000 | -16.9% |
P
S
|
1,772,131 | $5,458,163 | 2024 Q2 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
ENPH
ENPHASE ENERGY ...
|
Technology | 0.86% | 1.16% |
#43
9
Prev: #34
|
0.3 |
—
|
-44,081 | -23.6% |
P
S
|
142,419 | $5,384,862 | 2020 Q2 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
RVMD
REVOLUTION MEDI...
|
Healthcare | 0.85% | 0.81% |
#44
6
Prev: #50
|
0.8 |
—
|
2,610 | 5.0% |
P
S
|
55,110 | $5,359,448 | 2025 Q3 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
PFE
PFIZER INC
|
Healthcare | 0.83% | 0.41% |
#45
28
Prev: #73
|
3.3 |
—
|
100,000 | 116.3% |
P
S
|
186,000 | $5,222,880 | 2013 Q4 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
BHVN
BIOHAVEN LTD
|
Healthcare | 0.80% | — |
#46
Prev: #—
|
3.8 |
—
|
594,000 | — |
NEW
|
594,000 | $5,025,240 | 2018 Q1 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
FBRX
FORTE BIOSCIENC...
|
Healthcare | 0.76% | 0.98% |
#47
4
Prev: #43
|
0.8 |
—
|
-885 | -0.5% |
P
S
|
184,984 | $4,791,086 | 2025 Q2 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
CYBN
CYBIN INC
|
Unknown | 0.75% | 1.31% |
#48
22
Prev: #26
|
2.3 |
—
|
161,514 | 19.6% |
P
S
|
987,090 | $4,738,032 | 2024 Q1 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
MDGL
MADRIGAL PHARMA...
|
Healthcare | 0.75% | 0.37% |
#49
27
Prev: #76
|
3.3 |
—
|
5,740 | 173.9% |
P
S
|
9,040 | $4,732,169 | 2023 Q1 | 13F Filing | 2026-03-31 | 2026-05-15 | |||
|
SRRK
SCHOLAR ROCK HL...
|
Healthcare | 0.74% | 1.35% |
#50
27
Prev: #23
|
0.3 |
—
|
-64,000 | -40.4% |
P
S
|
94,265 | $4,634,067 | 2018 Q2 | 13F Filing | 2026-03-31 | 2026-05-15 |
Showing 1-50 of 121 holdings