SPHERA FUNDS MANAGEMENT LTD. reported WAVE LIFE SCIENCES LTD (WVE) in 6 quarterly 13F filings from 2025 Q3 through 2025 Q4. Peak portfolio weight reached 1.34% in 2025 Q4. The latest visible filing shows WVE at 1.34% of the fund.
This page tracks quarterly shares, estimated market value, portfolio weight, filing dates, and disclosure-aligned stock prices directly from SEC EDGAR 13F filings. Older history is available after unlock; the visible window still shows the most recent pattern.
This page is designed to answer the real investor question behind a 13F filing: how meaningful was SPHERA FUNDS MANAGEMENT LTD.'s position in WAVE LIFE SCIENCES LTD, and how did that conviction change over time? You can read the holding window, peak weight, latest reported size, disclosure timing, and quarter-by-quarter changes without piecing the story together from raw SEC rows.
WVE was reported at 1.34% of portfolio in the most recent visible filing.
Peak weight helps separate a token disclosure from a real conviction holding the fund genuinely cared about.
Longer holding windows often tell a very different story from short-lived tactical trades or one-quarter experiments.
Knowing that a fund owned a stock is useful. Knowing whether it was a 0.20% placeholder or a true high-conviction position is where the signal actually starts.
As of 2026 Q1 β sorted by position size
These are the practical questions this page is built to answer before you even open the full history table.
SPHERA FUNDS MANAGEMENT LTD. reported WVE across 2 quarterly 13F filings, from 2025 Q3 through 2025 Q4.
The largest reported portfolio weight for WVE was 1.34% in 2025 Q4.
The most recent filing on this page is 2025 Q4, when SPHERA FUNDS MANAGEMENT LTD. reported 408,166 shares, equal to 1.34% of portfolio, with an estimated market value of $6.9M.
The chart compares SPHERA FUNDS MANAGEMENT LTD.'s quarterly WVE portfolio weight with the stock's indexed share price, so you can see whether the fund was building, trimming, or holding the position as price moved.
Based on 13F filing dates vs. subsequent WVE price moves, SPHERA FUNDS MANAGEMENT LTD. correctly timed 3 out of 5 reported position changes (60%). The annualised alpha on WVE relative to SPY over the holding period was -90.4%.