RA CAPITAL MANAGEMENT, L.P.

All Holdings — 2025 Q4

AI Portfolio Summary
In 2025 Q4, RA CAPITAL MANAGEMENT, L.P. maintained a portfolio of 88 distinct positions. The most significant new addition to the portfolio was BIOCRYST PHARMACEUTI, which now represents 1.26% of the total fund value. They heavily accumulated shares in RHYTHM PHARMACEUTICA, increasing their position by 17.3%. Conversely, RA CAPITAL MANAGEMENT, L.P. completely exited their position in 89BIO INC.
PCA Score Concentration Risk
Risk ENB
Total Positions
88
Quarter
2025 Q4
Top Holding
ASND (22.5%)
Top 10 Concentration
65.6%
Turnover Rate
23.4%
Sector HHI
0.18
Items per page:
1-25 of 88
Stock History Sector / Type Port % Prev % Rank / Prev Conviction Change % Change Influence Shares Mkt Value Avg Cost Price Held 1st Owned Source Source Date Date Reported
ASND
ASCENDIS PHARMA...
Healthcare 22.46% 25.19% #1
Prev: #1
9.0 no change no change
P
S
10,281,496 $2,192,426,207 2007 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
CDTX
CIDARA THERAPEU...
Healthcare 7.62% 3.97% #2 3
Prev: #5
3.0 no change no change
P
S
3,365,523 $743,410,375 2007 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
RYTM
RHYTHM PHARMACE...
Healthcare 7.31% 7.07% #3 1
Prev: #2
5.0 985,478 17.3%
P
S
6,666,837 $713,618,232 2007 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
RNA
AVIDITY BIOSCIE...
Healthcare 6.39% 4.64% #4
Prev: #4
2.6 no change no change
P
S
8,641,031 $623,277,566 2007 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
PCVX
VAXCYTE INC
Healthcare 5.07% 5.31% #5 2
Prev: #3
2.1 -1,241,392 -10.4%
P
S
10,724,599 $494,832,998 2007 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
SION
SIONNA THERAPEU...
Healthcare 4.17% 3.79% #6
Prev: #6
1.7 -540,277 -5.2%
P
S
9,905,045 $407,493,551 2007 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
NAMS
NEWAMSTERDAM PH...
Healthcare 3.43% 3.55% #7 1
Prev: #8
1.4 -588,747 -5.8%
P
S
9,550,191 $335,020,700 2007 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
TYRA
TYRA BIOSCIENCE...
Healthcare 3.29% 2.10% #8 5
Prev: #13
1.3 no change no change
P
S
12,198,625 $320,701,851 2007 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
WVE
WAVE LIFE SCIEN...
Healthcare 3.17% 1.64% #9 6
Prev: #15
3.3 1,000 0.0%
P
S
18,203,009 $309,451,153 2007 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
MLYS
MINERALYS THERA...
Healthcare 2.72% 3.42% #10 1
Prev: #9
1.1 no change no change
P
S
7,323,750 $265,778,888 2007 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
EWTX
EDGEWISE THERAP...
Healthcare 2.65% 2.08% #11 3
Prev: #14
1.1 no change no change
P
S
10,428,437 $258,781,664 2007 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
SEPN
SEPTERNA INC
Healthcare 2.00% 1.62% #12 4
Prev: #16
0.8 no change no change
P
S
6,995,858 $195,044,521 2007 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
NUVL
NUVALENT INC-A
Healthcare 1.94% 1.33% #13 8
Prev: #21
2.9 633,601 50.8%
P
S
1,880,057 $189,114,934 2007 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
IRON
DISC MEDICINE I...
Healthcare 1.61% 1.28% #14 8
Prev: #22
2.7 399,026 25.3%
P
S
1,976,132 $156,924,642 2007 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
JANX
JANUX THERAPEUT...
Healthcare 1.58% 3.37% #15 5
Prev: #10
0.6 no change no change
P
S
11,189,693 $154,417,763 2007 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
PEPG
PEPGEN INC
Healthcare 1.34% 1.14% #16 9
Prev: #25
0.5 no change no change
P
S
20,064,545 $130,620,188 2007 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
TSHA
TAYSHA GENE THE...
Healthcare 1.33% 0.95% #17 10
Prev: #27
0.5 no change no change
P
S
23,555,648 $129,556,064 2007 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
SPRY
ARS PHARMACEUTI...
Healthcare 1.30% 1.34% #18 2
Prev: #20
0.5 no change no change
P
S
10,860,977 $126,530,382 2007 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
BCRX
BIOCRYST PHARMA...
Healthcare 1.26% #19
Prev: #—
2.5 15,827,186 no change
NEW
15,827,186 $123,452,051 2007 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
BCAX
BICARA THERAPEU...
Healthcare 1.20% 1.35% #20 2
Prev: #18
0.5 no change no change
P
S
6,955,993 $117,069,362 2007 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
PRAX
PRAXIS PRECISIO...
Healthcare 1.13% #21
Prev: #—
2.5 373,787 no change
NEW
373,787 $110,169,980 2007 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
GHRS
GH RESEARCH PLC
Healthcare 1.00% 1.35% #22 3
Prev: #19
0.4 no change no change
P
S
7,676,697 $97,494,052 2007 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
GERN
GERON CORP
Healthcare 0.86% 1.02% #23 3
Prev: #26
2.4 3,392,000 5.6%
P
S
63,771,366 $84,178,203 2007 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
ACLX
ARCELLX INC
Healthcare 0.85% 3.07% #24 13
Prev: #11
0.5 -1,769,371 -58.3%
P
S
1,267,156 $82,618,571 2007 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
CLYM
CLIMB BIO INC
Healthcare 0.80% 0.78% #25 4
Prev: #29
0.5 -20,125,439 -64.1%
P
S
11,293,828 $77,711,233 2007 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
ETNB
89BIO INC
Unknown 0.00% 3.60%
Sold All 😨
(Was: #7)
0.3 -19,889,683 -100.0%
CLOSED
$— 2019 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
SRRK
SCHOLAR ROCK HO...
Healthcare 0.00% 0.54%
Sold All 😨
(Was: #30)
0.3 -1,166,788 -100.0%
CLOSED
$— 2024 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
GPCR
STRUCTURE THERA...
Healthcare 0.00% 0.52%
Sold All 😨
(Was: #31)
0.3 -1,517,418 -100.0%
CLOSED
$— 2023 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
MTSR
METSERA INC
Healthcare 0.00% 0.44%
Sold All 😨
(Was: #35)
0.3 -675,525 -100.0%
CLOSED
$— 2025 Q1 13F Filing 2025-12-31 2026-02-14 (Est.)
TVTX
TRAVERE THERAPE...
Healthcare 0.00% 0.34%
Sold All 😨
(Was: #38)
0.3 -1,150,000 -100.0%
CLOSED
$— 2020 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
LRMR
LARIMAR THERAPE...
Healthcare 0.00% 0.24%
Sold All 😨
(Was: #43)
0.3 -6,045,351 -100.0%
CLOSED
$— 2020 Q2 13F Filing 2025-12-31 2026-02-14 (Est.)
TNGX
TANGO THERAPEUT...
Healthcare 0.00% 0.21%
Sold All 😨
(Was: #45)
0.3 -2,000,000 -100.0%
CLOSED
$— 2021 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
PRME
PRIME MEDICINE ...
Healthcare 0.00% 0.20%
Sold All 😨
(Was: #46)
0.3 -3,000,000 -100.0%
CLOSED
$— 2025 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
RCUS
ARCUS BIOSCIENC...
Healthcare 0.00% 0.19%
Sold All 😨
(Was: #47)
0.3 -1,136,364 -100.0%
CLOSED
$— 2025 Q1 13F Filing 2025-12-31 2026-02-14 (Est.)
QURE
UNIQURE NV
Healthcare 0.00% 0.14%
Sold All 😨
(Was: #50)
0.3 -200,000 -100.0%
CLOSED
$— 2020 Q1 13F Filing 2025-12-31 2026-02-14 (Est.)
ELDN
ELEDON PHARMACE...
Healthcare 0.00% 0.11%
Sold All 😨
(Was: #51)
0.3 -3,566,338 -100.0%
CLOSED
$— 2024 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
CTMX
CYTOMX THERAPEU...
Healthcare 0.00% 0.10%
Sold All 😨
(Was: #55)
0.3 -2,661,331 -100.0%
CLOSED
$— 2021 Q1 13F Filing 2025-12-31 2026-02-14 (Est.)
SRZN
SURROZEN INC
Healthcare 0.00% 0.10%
Sold All 😨
(Was: #58)
0.3 -602,626 -100.0%
CLOSED
$— 2024 Q2 13F Filing 2025-12-31 2026-02-14 (Est.)
EVH
EVOLENT HEALTH ...
Healthcare 0.00% 0.06%
Sold All 😨
(Was: #62)
0.3 -579,052 -100.0%
CLOSED
$— 2023 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
GKOS
GLAUKOS CORP
Healthcare 0.00% 0.05%
Sold All 😨
(Was: #63)
0.3 -54,180 -100.0%
CLOSED
$— 2025 Q1 13F Filing 2025-12-31 2026-02-14 (Est.)
EXAS
EXACT SCIENCES ...
Healthcare 0.00% 0.04%
Sold All 😨
(Was: #65)
0.3 -54,939 -100.0%
CLOSED
$— 2025 Q3 13F Filing 2025-12-31 2026-02-14 (Est.)
IFRX
INFLARX NV
Healthcare 0.00% 0.03%
Sold All 😨
(Was: #66)
0.3 -1,973,233 -100.0%
CLOSED
$— 2017 Q4 13F Filing 2025-12-31 2026-02-14 (Est.)
Showing 1-25 of 88 holdings

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