2026 Q2 Portfolio Activity
In 2026 Q2, RA CAPITAL MANAGEMENT, L.P. maintained a portfolio of 101 distinct positions. The most significant new addition was PARABILIS MEDICINES INC, now representing 6.88% of the total fund value. They heavily accumulated shares in SPYGLASS PHARMA INC, increasing the position by 828.3%. Conversely, RA CAPITAL MANAGEMENT, L.P. completely exited their position in DIANTHUS THERAPEUTICS INC.
Position History
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Total Positions
101
Quarter
2026 Q2
Top Holding
ASND (23.8%)
Top 10 Concentration
60.4%
Turnover Rate
23.4%
Sector HHI
0.18
Items per page:
Showing 1-50 of 101
RA CAPITAL MANAGEMENT, L.P. Full Holdings List — 2026 Q2
| Stock | History | Sector / Type | Port % | Prev % | Rank / Prev | Conviction | Change | % Change | Influence | Shares | Mkt Value | Avg Cost | Price Held | 1st Owned | Source | Source Date | Date Reported | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
ASND
ASCENDIS PHARMA...
|
Healthcare | 23.83% | 24.92% |
#1
Prev: #1
|
7.0 |
—
|
no change | no change |
P
S
|
10,281,496 | $2,742,280,613 |
$77.68
+192.5%
|
2007 Q4 | 13F Filing | 2026-06-30 | 2026-08-14 | ||
|
PBLS
PARABILIS MEDIC...
|
Healthcare | 6.88% | — |
#2
Prev: #—
|
7.8 |
—
|
28,933,371 | — |
NEW
|
28,933,371 | $791,906,364 |
$27.37
+2.3%
|
2026 Q2 | 13F Filing | 2026-06-30 | 2026-08-14 | ||
|
RYTM
RHYTHM PHARMACE...
|
Healthcare | 6.43% | 6.14% |
#3
Prev: #3
|
4.6 |
—
|
no change | no change |
P
S
|
6,666,837 | $740,218,912 |
$37.38
+147.7%
|
2007 Q4 | 13F Filing | 2026-06-30 | 2026-08-14 | ||
|
PCVX
VAXCYTE INC
|
Healthcare | 5.80% | 7.07% |
#4
2
Prev: #2
|
3.8 |
—
|
no change | no change |
P
S
|
11,474,599 | $667,018,440 | 2007 Q4 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
SION
SIONNA THERAPEU...
|
Healthcare | 3.79% | 4.21% |
#5
Prev: #5
|
3.0 |
—
|
no change | no change |
P
S
|
9,905,045 | $435,722,930 | 2007 Q4 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
TYRA
TYRA BIOSCIENCE...
|
Healthcare | 3.39% | 4.95% |
#6
2
Prev: #4
|
2.4 |
—
|
no change | no change |
P
S
|
12,198,625 | $389,624,083 | 2007 Q4 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
EWTX
EDGEWISE THERAP...
|
Healthcare | 2.96% | 3.48% |
#7
1
Prev: #6
|
1.7 |
—
|
-2,035,707 | -19.5% |
P
S
|
8,392,730 | $340,996,620 | 2007 Q4 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
NAMS
NEWAMSTERDAM PH...
|
Healthcare | 2.81% | 3.24% |
#8
1
Prev: #7
|
2.1 |
—
|
no change | no change |
P
S
|
9,550,191 | $323,655,973 | 2007 Q4 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
COAG
HEMAB THERAPEUT...
|
Healthcare | 2.49% | — |
#9
Prev: #—
|
4.5 |
—
|
7,808,627 | — |
NEW
|
7,808,627 | $286,810,870 | 2026 Q2 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
SEPN
SEPTERNA INC
|
Healthcare | 2.04% | 1.78% |
#10
3
Prev: #13
|
1.8 |
—
|
no change | no change |
P
S
|
6,995,858 | $234,291,284 | 2007 Q4 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
BCAX
BICARA THERAPEU...
|
Healthcare | 1.87% | 1.53% |
#11
6
Prev: #17
|
1.7 |
—
|
no change | no change |
P
S
|
7,255,993 | $215,430,432 | 2007 Q4 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
MLYS
MINERALYS THERA...
|
Healthcare | 1.80% | 2.21% |
#12
2
Prev: #10
|
1.7 |
—
|
no change | no change |
P
S
|
7,692,750 | $207,550,395 | 2007 Q4 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
GHRS
GH RESEARCH PLC
|
Healthcare | 1.78% | 1.14% |
#13
6
Prev: #19
|
1.2 |
—
|
-39,884 | -0.5% |
P
S
|
7,636,813 | $205,277,533 | 2007 Q4 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
IRON
DISC MEDICINE I...
|
Healthcare | 1.56% | 1.66% |
#14
Prev: #14
|
1.6 |
—
|
no change | no change |
P
S
|
2,450,221 | $179,209,164 | 2007 Q4 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
N/A
SPYGLASS PHARMA...
|
|
Unknown | 1.55% | 2.20% |
#15
4
Prev: #11
|
1.6 |
—
|
no change | no change |
P
S
|
8,021,117 | $178,550,064 | — | 13F Filing | 2026-06-30 | 2026-08-14 | ||
|
ARTV
ARTIVA BIOTHERA...
|
Healthcare | 1.51% | 0.67% |
#16
14
Prev: #30
|
3.6 |
—
|
8,102,340 | 82.2% |
P
S
|
17,955,642 | $174,169,727 | 2007 Q4 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
JANX
JANUX THERAPEUT...
|
Healthcare | 1.49% | 1.65% |
#17
2
Prev: #15
|
1.6 |
—
|
no change | no change |
P
S
|
11,189,693 | $171,873,684 | 2007 Q4 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
TSHA
TAYSHA GENE THE...
|
Healthcare | 1.39% | 1.12% |
#18
3
Prev: #21
|
1.6 |
—
|
no change | no change |
P
S
|
23,555,648 | $160,413,963 | 2007 Q4 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
BCRX
BIOCRYST PHARMA...
|
Healthcare | 1.38% | 1.60% |
#19
3
Prev: #16
|
1.6 |
—
|
no change | no change |
P
S
|
15,827,186 | $158,271,860 | 2007 Q4 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
WVE
WAVE LIFE SCIEN...
|
Healthcare | 1.36% | 2.07% |
#20
8
Prev: #12
|
1.5 |
—
|
no change | no change |
P
S
|
26,975,505 | $156,727,684 | 2007 Q4 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
NUVL
NUVALENT INC-A
|
Healthcare | 1.34% | 2.75% |
#21
13
Prev: #8
|
0.5 |
—
|
-1,287,689 | -50.8% |
P
S
|
1,246,456 | $153,937,316 | 2007 Q4 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
ABVX
ABIVAX SA-ADR
|
Healthcare | 1.31% | — |
#22
Prev: #—
|
4.0 |
—
|
1,132,557 | — |
NEW
|
1,132,557 | $150,924,546 | 2026 Q2 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
ORKA
ORUKA THERAPEUT...
|
Healthcare | 1.29% | — |
#23
Prev: #—
|
4.0 |
—
|
1,554,597 | — |
NEW
|
1,554,597 | $147,950,996 | 2026 Q2 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
CLYM
CLIMB BIO INC
|
Healthcare | 1.28% | 0.82% |
#24
4
Prev: #28
|
1.5 |
—
|
no change | no change |
P
S
|
11,300,939 | $147,364,245 | 2007 Q4 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
SLDB
SOLID BIOSCIENC...
|
Healthcare | 1.04% | 0.71% |
#25
4
Prev: #29
|
2.9 |
—
|
2,696,148 | 28.9% |
P
S
|
12,036,126 | $120,240,899 | 2007 Q4 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
ZLAB
ZAI LAB LTD-ADR
|
Healthcare | 0.95% | 1.14% |
#26
6
Prev: #20
|
0.9 |
—
|
36,271 | 0.6% |
P
S
|
5,743,533 | $109,127,127 | 2024 Q4 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
SPRY
ARS PHARMACEUTI...
|
Healthcare | 0.76% | 0.92% |
#27
3
Prev: #24
|
1.3 |
—
|
no change | no change |
P
S
|
10,860,977 | $86,996,426 | 2007 Q4 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
XNCR
XENCOR INC
|
Healthcare | 0.74% | 0.63% |
#28
4
Prev: #32
|
2.3 |
—
|
377,037 | 7.7% |
P
S
|
5,274,274 | $84,915,811 | 2013 Q4 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
JBIO
JADE BIOSCIENCE...
|
Healthcare | 0.71% | 0.55% |
#29
5
Prev: #34
|
1.3 |
—
|
no change | no change |
P
S
|
3,671,083 | $81,571,464 | 2007 Q4 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
NTLA
INTELLIA THERAP...
|
Healthcare | 0.67% | — |
#30
Prev: #—
|
3.8 |
—
|
4,526,926 | — |
NEW
|
4,526,926 | $76,595,588 | 2021 Q2 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
LBRX
LB PHARMACEUTIC...
|
Healthcare | 0.62% | 0.58% |
#31
2
Prev: #33
|
1.2 |
—
|
no change | no change |
P
S
|
2,208,604 | $71,680,243 | 2007 Q4 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
DFTX
DEFINIUM THERAP...
|
Healthcare | 0.61% | — |
#32
Prev: #—
|
3.7 |
—
|
1,500,000 | — |
NEW
|
1,500,000 | $70,560,000 | 2026 Q2 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
ACRS
ACLARIS THERAPE...
|
Healthcare | 0.58% | 0.27% |
#33
19
Prev: #52
|
3.2 |
—
|
5,918,954 | 87.0% |
P
S
|
12,723,026 | $67,304,808 | 2015 Q4 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
FDMT
4D MOLECULAR TH...
|
Healthcare | 0.58% | 0.50% |
#34
2
Prev: #36
|
1.2 |
—
|
no change | no change |
P
S
|
5,049,779 | $67,162,061 | 2007 Q4 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
SANA
SANA BIOTECHNOL...
|
Healthcare | 0.57% | — |
#35
Prev: #—
|
3.7 |
—
|
18,750,000 | — |
NEW
|
18,750,000 | $65,437,500 | 2026 Q2 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
GLTO
DAMORA THERAPEU...
|
Healthcare | 0.54% | 0.66% |
#36
5
Prev: #31
|
0.7 |
—
|
392 | 0.0% |
P
S
|
2,399,702 | $62,416,249 | 2026 Q1 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
MNPR
MONOPAR THERAPE...
|
Healthcare | 0.54% | 0.39% |
#37
5
Prev: #42
|
1.2 |
—
|
no change | no change |
P
S
|
667,207 | $61,776,696 | 2007 Q4 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
ABOS
ACUMEN PHARMACE...
|
Healthcare | 0.49% | 0.52% |
#38
3
Prev: #35
|
1.2 |
—
|
no change | no change |
P
S
|
20,992,669 | $56,050,426 | 2007 Q4 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
GERN
GERON CORP
|
Healthcare | 0.48% | 1.01% |
#39
16
Prev: #23
|
0.2 |
—
|
-20,961,615 | -32.9% |
P
S
|
42,809,751 | $54,796,481 | 2007 Q4 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
RZLT
REZOLUTE INC
|
Healthcare | 0.43% | 0.30% |
#40
9
Prev: #49
|
0.7 |
—
|
265,039 | 2.9% |
P
S
|
9,445,039 | $49,114,203 | 2007 Q4 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
EVMN
EVOMMUNE INC
|
Healthcare | 0.40% | 0.85% |
#41
14
Prev: #27
|
1.2 |
—
|
no change | no change |
P
S
|
3,494,638 | $46,443,739 | 2007 Q4 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
VOR
VOR BIOPHARMA I...
|
Healthcare | 0.38% | 1.02% |
#42
20
Prev: #22
|
0.2 |
—
|
-3,002,903 | -55.6% |
P
S
|
2,402,095 | $44,222,569 | 2007 Q4 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
IPSC
CENTURY THERAPE...
|
Healthcare | 0.38% | 0.43% |
#43
4
Prev: #39
|
1.2 |
—
|
no change | no change |
P
S
|
17,754,430 | $43,498,354 | 2021 Q2 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
AKTS
AKTIS ONCOLOGY ...
|
Healthcare | 0.37% | 0.28% |
#44
6
Prev: #50
|
0.6 |
—
|
-188,679 | -12.6% |
P
S
|
1,314,405 | $42,363,273 | 2026 Q1 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
BIOA
BIOAGE LABS INC
|
Healthcare | 0.36% | 0.31% |
#45
1
Prev: #46
|
0.6 |
—
|
21,000 | 1.3% |
P
S
|
1,671,648 | $40,972,092 | 2024 Q3 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
CCCC
C4 THERAPEUTICS...
|
Healthcare | 0.32% | 0.22% |
#46
11
Prev: #57
|
1.1 |
—
|
no change | no change |
P
S
|
8,000,000 | $37,360,000 | 2007 Q4 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
MIRM
MIRUM PHARMACEU...
|
Healthcare | 0.32% | 0.31% |
#47
2
Prev: #45
|
1.1 |
—
|
no change | no change |
P
S
|
318,554 | $37,293,117 | 2026 Q1 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
CAPR
CAPRICOR THERAP...
|
Healthcare | 0.32% | 0.49% |
#48
10
Prev: #38
|
1.1 |
—
|
no change | no change |
P
S
|
1,507,844 | $36,308,884 | 2007 Q4 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
PEPG
PEPGEN INC
|
Healthcare | 0.31% | 0.38% |
#49
6
Prev: #43
|
1.1 |
—
|
no change | no change |
P
S
|
20,064,545 | $36,116,181 | 2007 Q4 | 13F Filing | 2026-06-30 | 2026-08-14 | |||
|
PRLD
PRELUDE THERAPE...
|
Healthcare | 0.30% | — |
#50
Prev: #—
|
3.6 |
—
|
6,475,882 | — |
NEW
|
6,475,882 | $34,516,451 | 2026 Q2 | 13F Filing | 2026-06-30 | 2026-08-14 |
Showing 1-50 of 101 holdings