274 + Investors. Track Smart Money conviction in TWST. See who's accumulating, reducing, or initiating positions.
Based on 275 hedge funds · latest filing: 2026 Q1 · updated quarterly
Methodology note: these Smart Money cards use consecutive 13F disclosure snapshots, not trade-by-trade execution data. "Buying", "selling", "new holders", and "trimmed" refer to quarter-over-quarter changes in reported holders, aggregate shares, or disclosed position values between filings. They are useful for ownership regime analysis and crowding, but they do not imply exact trade timing on the filing date.
In 2026 Q1, 144 hedge funds were net buyers of TWST (69 opened a new position, 75 added to an existing one), while 121 reduced or exited (86 trimmed, 35 sold completely) — a 54% buyer ratio, indicating a slight buying edge. Net buying has persisted for two consecutive quarters, a positive momentum signal. 32% of total institutional value in TWST is held by top-100 AUM funds, reflecting strong institutional quality. Net fund flow last quarter: +34 funds (more new holders than closures). Total institutional holders: 275.
Institutional ownership data sourced from SEC EDGAR Form 13F-HR filings.
Signal Freshness measures how much TWST has moved relative to its sector benchmark (XLV) since the 2026 Q1 13F filing. A stock that has barely outrun its sector is still a relatively fresh entry point — the fund's thesis has not yet been priced in by the broader market.
TWST outperformed XLV by +68.7% since March 31, 2026.
Since the filing became public, TWST outperformed XLV by +61.8% .
Interpretation: The stock has significantly outperformed its sector benchmark — the original entry opportunity has largely been captured by earlier investors. Learn more →
No strong consensus or elite conviction detected among institutional holders.
Track Smart Money conviction in TWST. See who's accumulating, reducing, or initiating positions.
| Metric | All 13F Filers (2026 Q1) | Prior (2025 Q4) | Change |
|---|---|---|---|
| Funds Holding | 274 | 241 | 13.69% |
| 13F Shares | 77M | 75M | 2.36% |
| Total Value | $3.58B | $2.39B | 49.7% |
| New Positions | 68 | 54 | +14 |
| Increased Positions | 75 | 72 | +3 |
| Closed Positions | 35 | 43 | -8 |
| Reduced Positions | 85 | 77 | +8 |
| Total Calls | 3 | 5 | -40.0% |
| Total Puts | 3 | 3 | - |
| PUT/CALL Ratio | 1.0 | 0.6 | Neutral |
| Market Cap | -- |
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| PEG Ratio (5yr expected) | -- |
| Price/Sales (ttm) | -- |
| Price/Book (mrq) | -- |
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| Enterprise Value/EBITDA | -- |
| Beta (5Y Monthly) | -- |
| Short Ratio (Days to Cover) | -- |
| Short % of Float | -- |
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| Net Income Avi to Common (ttm) | -- |
| Diluted EPS (ttm) | -- |
| Total Cash (mrq) | -- |
| Total Debt/Equity (mrq) | -- |
| Levered Free Cash Flow (ttm) | -- |
Explore institutional interest and hedge fund ownership dynamics. Analyze portfolio weights, new positions, and conviction trends in TWST. Verified SEC 13F-HR filings.
| Investor | Ownership History |
% of Portfolio | Prev % | Rank | Conviction | Avg Buy Price | 13F Score™ 3Y / 7Y | Sell Timing | Shares | Mkt Value | Change | Change % | Source | Quarter | Filed |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Buying streak — 2 quarters in a row: For 2 consecutive quarters, more hedge funds added TWST than sold it. That's a consistent pattern of professional buying — not a one-time trade. When institutions keep buying quarter after quarter, it usually means they see a multi-year opportunity, not just a short-term momentum flip.
Slight buying edge — 54% buying: Last quarter: 144 funds bought or added vs 121 that reduced or exited. It's nearly a 50/50 split — some institutions are convinced, others are taking profits. This mixed picture is normal near price highs.
Strong quality — 32% AUM from major funds: 54 of 275 holders rank in the top 100 by AUM, accounting for 32% of total institutional value held. A meaningful share of the ownership value comes from the most well-resourced institutions.
56% of holders stayed for 2+ years: 154 out of 275 hedge funds have held TWST for over 2 years without selling. Long-term investors are generally harder to shake out during market stress, creating a stable ownership base that limits the risk of sudden capitulation.
As of today, TWST has moved +67.4% since the 2026 Q1 13F filing date (May 15, 2026), compared to +5.6% for the XLV sector ETF — an outperformance of +61.8%. Since the quarter end (March 31, 2026), TWST has gained +73.2% vs +4.5% for XLV. The stock has significantly outperformed its sector benchmark — the original entry opportunity has largely been captured by earlier investors.
All holdings data is sourced from SEC Form 13F filings, which institutional investment managers with over $100 million in assets are required to submit quarterly. Data is parsed directly from SEC EDGAR.
Disclaimer: The information on this page is for informational purposes only and does not constitute investment advice, a recommendation, or an offer to buy or sell any security. Institutional holdings data is sourced from SEC Form 13F filings and reflects positions as of the filing date. Past performance of any fund or portfolio is not indicative of future results. 13Foresight is not a registered investment adviser. Always conduct your own due diligence before making investment decisions.