Stock Analysis
Data Source: SEC EDGAR 13F
Updated Hourly

Pyxis Oncology Inc (PYXS)

76 + Investors. Track Smart Money conviction in PYXS. See who's accumulating, reducing, or initiating positions.

Current Price
-- USD
Analyst Target
-- (0 analysts)
Upside
0.00%
Net Flow Q/Q
↑ +2
Streak
1Q ▲
Buyers last Q
51%

Smart Money Signals — PYXS

Based on 79 hedge funds · latest filing: 2026 Q2 · updated quarterly

📈

Buying streak — 1 quarter in a row

last 6Q
For 1 consecutive quarter, more hedge funds added PYXS than sold it. That's a consistent pattern of professional buying — not a one-time trade. When institutions keep buying quarter after quarter, it usually means they see a multi-year opportunity, not just a short-term momentum flip.
📊

High ownership — 81% of 3.0Y peak

81% of all-time peak
79 funds currently hold this stock — 81% of the 3.0-year high of 98 funds (reached 2024 Q4). Ownership is elevated but not yet at maximum concentration. Room to grow, but watch if the trend reverses.
📶

Steady growth — +4% more funds vs a year ago

fund count last 6Q
+3 new funds entered over the past year (+4% YoY). Gradual, steady growth in institutional ownership is generally a healthy signal — not a speculative rush, but consistent conviction.
🟡

Slight buying edge — 51% buying

39 buying37 selling
Last quarter: 39 funds bought or added vs 37 that reduced or exited. It's nearly a 50/50 split — some institutions are convinced, others are taking profits. This mixed picture is normal near price highs.
➡️

Steady new buyers — ~14 new funds per quarter

new funds entering per quarter
Funds opening this position for the first time: 14 → 22 → 14 → 14. A stable flow of new institutional buyers suggests ongoing interest without signs of either acceleration or slowdown.
🔒

47% of holders stayed for 2+ years

■ 47% conviction (2yr+) ■ 29% medium ■ 24% new
37 out of 79 hedge funds have held PYXS for over 2 years without selling. Long-term investors are generally harder to shake out during market stress, creating a stable ownership base that limits the risk of sudden capitulation.
💎

Buying through price weakness — shares +24%, value -83%

Value
-83%
Shares
+23%
Last quarter: funds added +24% more shares while total portfolio value only changed -83%. Institutions were buying while the price was falling — a high-conviction accumulation signal. They're deliberately loading up on the dip.
📊

Peak discovery — momentum slowing

16 → 14 → 22 → 14 → 14 new funds/Q
New funds entering each quarter: 14 → 22 → 14 → 14. PYXS is well-known in the hedge fund world, but fresh entries are gradually declining. The explosive phase of institutional discovery is likely behind us.
🏛️

Veteran-anchored — 55% veterans vs 26% newcomers

■ 55% veterans ■ 20% 1-2yr ■ 26% new
Entry-cohort mix of 82 holders: 45 (55%) are 2+ year veterans, 16 entered 1–2 years ago, and 21 (26%) joined within the past year. A veteran-weighted cap table skews toward institutional memory over fresh momentum.
📋

Smaller funds dominant — 9% AUM from top-100

9% from top-100 AUM funds
25 of 76 holders rank in the top 100 by AUM, but together hold only 9% of total institutional value. The stock is held primarily by smaller and mid-sized funds.
2.7
out of 10
Low Exit Risk
Exit risk score 2.7/10 — low institutional crowding. Ownership is below peak levels, holder base is relatively sticky, and buying momentum is positive.

Methodology note: these Smart Money cards use consecutive 13F disclosure snapshots, not trade-by-trade execution data. "Buying", "selling", "new holders", and "trimmed" refer to quarter-over-quarter changes in reported holders, aggregate shares, or disclosed position values between filings. They are useful for ownership regime analysis and crowding, but they do not imply exact trade timing on the filing date.

Institutional Sentiment Summary — PYXS

In 2026 Q2, 39 hedge funds were net buyers of PYXS (14 opened a new position, 25 added to an existing one), while 37 reduced or exited (25 trimmed, 12 sold completely) — a 51% buyer ratio, indicating a slight buying edge. Net fund flow last quarter: +2 funds (more new holders than closures). Total institutional holders: 79.

Hedge Fund Ownership: PYXS

How many hedge funds hold PYXS — quarterly history vs. share price
Quarterly hedge fund ownership of PYXS vs. share price

Market Analysis: PYXS

Analyst Price Targets

Avg. Price Target
--

Analyst Recommendations

Stock Performance

Real-time

Company Profile: PYXS

-- --

Institutional ownership data sourced from SEC EDGAR Form 13F-HR filings.

Is It Too Late to Buy Pyxis Oncology Inc (PYXS) Based on Hedge Fund 13F Filings?

Signal Freshness measures how much PYXS has moved relative to its sector benchmark (XLV) since the 2026 Q2 13F filing. A stock that has barely outrun its sector is still a relatively fresh entry point — the fund's thesis has not yet been priced in by the broader market.

Since Quarter End June 30, 2026 · 85d ago
PYXS
+6.0%
XLV
+6.9%

PYXS outperformed XLV by -0.9% since June 30, 2026.

Since 13F Filing Date August 14, 2026 · 40d ago
PYXS
+6.0%
XLV
+1.4%

Since the filing became public, PYXS outperformed XLV by +4.6% .

Interpretation: The stock is tracking its sector benchmark closely. The signal remains fresh and the entry point is still near the fund's implied reference. Learn more →

Smart Money Signal ?
Limited Smart Money Interest

No strong consensus or elite conviction detected among institutional holders.

6 top-rated funds 2 high-conviction
Consensus
3.7
/ 10
breadth
×
Elite
1.7
/ 10
conviction
Hedge Fund Positioning: PYXS
76 + Investors

Track Smart Money conviction in PYXS. See who's accumulating, reducing, or initiating positions.

Metric All 13F Filers (2026 Q2) Prior (2026 Q1) Change
Funds Holding 76 77 -1.3%
13F Shares 35M 28M 23.6%
Total Value $102M $601M -82.97%
New Positions 14 14 -
Increased Positions 24 11 +13
Closed Positions 12 16 -4
Reduced Positions 24 33 -9
Total Calls 5 3 66.67%
Total Puts 1 0 100%
PUT/CALL Ratio 0.2 0.0 Bullish

Statistics: PYXS

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Valuation Measures Data as of: --

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PEG Ratio (5yr expected) --
Price/Sales (ttm) --
Price/Book (mrq) --
Enterprise Value/Revenue --
Enterprise Value/EBITDA --
Beta (5Y Monthly) --
Short Ratio (Days to Cover) --
Short % of Float --

Financial Highlights

Profitability
Profit Margin --
Return on Assets (ttm) --
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Net Income Avi to Common (ttm) --
Diluted EPS (ttm) --
Total Cash (mrq) --
Total Debt/Equity (mrq) --
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Institutional Holders (2026 Q2)

76 + investors

Explore institutional interest and hedge fund ownership dynamics. Analyze portfolio weights, new positions, and conviction trends in PYXS. Verified SEC 13F-HR filings.

QUARTER:
Top 25 PYXS holders by conviction (% of portfolio weight) — 2026 Q2 · Source: SEC Form 13F
# Investor % of Portfolio Shares Mkt Value
1 GordonMD Global Investments LP 14.60% 10,024,909 $30.2M
2 Pfizer Inc 11.43% 7,032,770 $19.5M
3 Atle Fund Management AB 0.78% 966,459 $2.9M
4 Laurion Capital Management LP 0.38% 4,900,888 $14.8M
5 Palo Alto Investors LP 0.36% 864,277 $2.6M
6 Diadema Partners LP 0.15% 388,200 $1.2M
7 Decheng Capital LLC 0.13% 326,810 $984K
8 Verdad Advisers, LP 0.13% 44,899 $135K
9 683 Capital Management, LLC 0.07% 459,367 $1.4M
10 University of Chicago 0.03% 48,731 $147K
11 J. Derek Lewis & Associates Inc. 0.02% 42,000 $126K
12 Longaeva Partners L.P. 0.02% 353,582 $1.1M
13 MYDA Advisors LLC 0.02% 50,000 $150K
14 Paces Ferry Wealth Advisors, LLC 0.01% 11,440 $34K
15 Hager Investment Management Services, LLC 0.01% 5,000 $15K
16 Woodline Partners LP 0.00% 523,999 $1.6M
17 Jacobs Levy Equity Management, Inc 0.00% 428,606 $1.3M
18 XTX Topco Ltd 0.00% 110,939 $334K
19 Bridgeway Capital Management, LLC 0.00% 81,260 $245K
20 Cable Car Capital, LP 0.00% 61,606 $185K
21 NewEdge Wealth, LLC 0.00% 116,006 $349K
22 Renaissance Technologies LLC 0.00% 772,232 $2.3M
23 First United Bank & Trust 0.00% 2,500 $7K
24 Marshall Wace, LLP 0.00% 830,544 $2.5M
25 China Universal Asset Management Co., Ltd. 0.00% 10,083 $30K
Investor Ownership
History 		% of Portfolio Prev % Rank Conviction Avg Buy Price 13F Score™ 3Y / 7Y Sell Timing Shares Mkt Value Change Change % Source Quarter Filed

Frequently Asked Questions — Pyxis Oncology Inc (PYXS)

What does the Smart Money Trend signal show for PYXS?

Buying streak — 1 quarter in a row: For 1 consecutive quarter, more hedge funds added PYXS than sold it. That's a consistent pattern of professional buying — not a one-time trade. When institutions keep buying quarter after quarter, it usually means they see a multi-year opportunity, not just a short-term momentum flip.

What is the institutional breadth score for PYXS?

Slight buying edge — 51% buying: Last quarter: 39 funds bought or added vs 37 that reduced or exited. It's nearly a 50/50 split — some institutions are convinced, others are taking profits. This mixed picture is normal near price highs.

What is the fund quality score for PYXS holders?

Smaller funds dominant — 9% AUM from top-100: 25 of 76 holders rank in the top 100 by AUM, but together hold only 9% of total institutional value. The stock is held primarily by smaller and mid-sized funds.

How long have hedge funds held PYXS?

47% of holders stayed for 2+ years: 37 out of 79 hedge funds have held PYXS for over 2 years without selling. Long-term investors are generally harder to shake out during market stress, creating a stable ownership base that limits the risk of sudden capitulation.

Is it too late to buy Pyxis Oncology Inc (PYXS) following the 2026 Q2 hedge fund 13F filings?

As of today, PYXS has moved +6.0% since the 2026 Q2 13F filing date (August 14, 2026), compared to +1.4% for the XLV sector ETF — an outperformance of +4.6%. Since the quarter end (June 30, 2026), PYXS has gained +6.0% vs +6.9% for XLV. The stock is tracking its sector benchmark closely. The signal remains fresh and the entry point is still near the fund's implied reference.

Where does this institutional ownership data come from?

All holdings data is sourced from SEC Form 13F filings, which institutional investment managers with over $100 million in assets are required to submit quarterly. Data is parsed directly from SEC EDGAR.

Disclaimer: The information on this page is for informational purposes only and does not constitute investment advice, a recommendation, or an offer to buy or sell any security. Institutional holdings data is sourced from SEC Form 13F filings and reflects positions as of the filing date. Past performance of any fund or portfolio is not indicative of future results. 13Foresight is not a registered investment adviser. Always conduct your own due diligence before making investment decisions.

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