Stock Analysis
Data Source: SEC EDGAR 13F
Updated Hourly

Prime Medicine Inc (PRME)

181 + Investors. Track Smart Money conviction in PRME. See who's accumulating, reducing, or initiating positions.

Current Price
-- USD
Analyst Target
-- (0 analysts)
Upside
0.00%
Net Flow Q/Q
↓ -5
Streak
1Q ▼
Buyers last Q
48%

Smart Money Signals — PRME

Based on 184 hedge funds · latest filing: 2026 Q2 · updated quarterly

📉

Selling streak — 1 quarter in a row

last 6Q
For 1 consecutive quarter, more hedge funds reduced or closed their PRME positions than added to them. Sustained institutional selling is a meaningful warning sign — these are professionals with deep research teams collectively deciding to exit.
🏔️

At the ownership peak (97% of max)

97% of all-time peak
184 hedge funds hold PRME right now — the highest count in 3.0 years. When ownership is this concentrated, any bad news can trigger a chain reaction: one big fund sells, others follow. This is a classic 'crowded trade' — high popularity doesn't equal safety.
🚀

Fast accumulation — +52% more funds vs a year ago

fund count last 6Q
+63 new funds entered over the past year (+52% YoY). That's a rapid rush of institutional money. Fast accumulation often signals a major thesis — but it also means the stock could fall quickly if that thesis breaks.
🟠

More sellers than buyers — 48% buying

89 buying97 selling
Last quarter: 97 funds reduced or exited vs 89 that bought or added. When more than half of active funds are selling, it's a caution flag — especially if the stock price hasn't moved down yet.
⚠️

Fewer new buyers each quarter (-15 vs last Q)

new funds entering per quarter
Funds opening this position for the first time: 50 → 48 → 39 → 24. Each quarter fewer new institutions are entering. This usually means most funds that wanted in are already in — the stock is well-known but the pool of potential new buyers is shrinking.
📌

Mixed — 37% long-term, 29% new

■ 37% conviction (2yr+) ■ 34% medium ■ 29% new
Of the 184 current holders: 68 (37%) held >2 years, 63 held 1–2 years, and 53 entered in the last year. A mixed base — the stock has long-term believers but also recent buyers who haven't been tested by a downturn yet.
💰

Value +62% but shares only +7% — price-driven

Value
+62%
Shares
+7%
Last quarter: the total dollar value of institutional holdings rose +62%, but actual share count only changed +7%. The gap is explained by the stock's price rising — not new buying. Strong value growth with weak share growth means the rally is price momentum, not fresh institutional demand.
📊

Peak discovery — momentum slowing

28 → 50 → 48 → 39 → 24 new funds/Q
New funds entering each quarter: 50 → 48 → 39 → 24. PRME is well-known in the hedge fund world, but fresh entries are gradually declining. The explosive phase of institutional discovery is likely behind us.
🏛️

Veteran-anchored — 41% veterans vs 39% newcomers

■ 41% veterans ■ 20% 1-2yr ■ 39% new
Entry-cohort mix of 189 holders: 78 (41%) are 2+ year veterans, 38 entered 1–2 years ago, and 73 (39%) joined within the past year. A veteran-weighted cap table skews toward institutional memory over fresh momentum.
🏆

Elite ownership — 61% AUM from top-100 funds

61% from top-100 AUM funds
46 of 183 holders are among the 100 largest funds by AUM, controlling 61% of total institutional value in PRME. When the biggest players dominate the cap table, it signifies deep institutional support — since mega-funds deploy the most rigorous due diligence and capital.
4.1
out of 10
Moderate Exit Risk
Exit risk score 4.1/10 — some crowding factors present, but no critical concentration. Watch ownership trend over the next 1–2 quarters for direction.

Methodology note: these Smart Money cards use consecutive 13F disclosure snapshots, not trade-by-trade execution data. "Buying", "selling", "new holders", and "trimmed" refer to quarter-over-quarter changes in reported holders, aggregate shares, or disclosed position values between filings. They are useful for ownership regime analysis and crowding, but they do not imply exact trade timing on the filing date.

Institutional Sentiment Summary — PRME

In 2026 Q2, 89 hedge funds were net buyers of PRME (24 opened a new position, 65 added to an existing one), while 97 reduced or exited (68 trimmed, 29 sold completely) — a 48% buyer ratio, indicating roughly balanced activity. 61% of total institutional value in PRME is held by top-100 AUM funds, reflecting elite-tier ownership quality. Net fund flow last quarter: -5 funds (more exits than new entries). Total institutional holders: 184.

Hedge Fund Ownership: PRME

How many hedge funds hold PRME — quarterly history vs. share price
Quarterly hedge fund ownership of PRME vs. share price

Market Analysis: PRME

Analyst Price Targets

Avg. Price Target
--

Analyst Recommendations

Stock Performance

Real-time

Company Profile: PRME

-- --

Institutional ownership data sourced from SEC EDGAR Form 13F-HR filings.

Loading signal freshness…
Smart Money Signal ?
Limited Smart Money Interest

No strong consensus or elite conviction detected among institutional holders.

11 top-rated funds 0 high-conviction
Consensus
4.7
/ 10
breadth
×
Elite
0.8
/ 10
conviction
Hedge Fund Positioning: PRME
181 + Investors

Track Smart Money conviction in PRME. See who's accumulating, reducing, or initiating positions.

Metric All 13F Filers (2026 Q2) Prior (2026 Q1) Change
Funds Holding 181 189 -4.23%
13F Shares 105M 99M 6.49%
Total Value $364M $321M 13.51%
New Positions 24 39 -15
Increased Positions 62 73 -11
Closed Positions 31 32 -1
Reduced Positions 67 48 +19
Total Calls 3 3 -
Total Puts 3 3 -
PUT/CALL Ratio 1.0 1.0 Neutral

Statistics: PRME

View More

Valuation Measures Data as of: --

Market Cap --
Enterprise Value --
Trailing P/E --
Forward P/E --
PEG Ratio (5yr expected) --
Price/Sales (ttm) --
Price/Book (mrq) --
Enterprise Value/Revenue --
Enterprise Value/EBITDA --
Beta (5Y Monthly) --
Short Ratio (Days to Cover) --
Short % of Float --

Financial Highlights

Profitability
Profit Margin --
Return on Assets (ttm) --
Return on Equity (ttm) --
Income Statement & Cash Flow
Revenue (ttm) --
Net Income Avi to Common (ttm) --
Diluted EPS (ttm) --
Total Cash (mrq) --
Total Debt/Equity (mrq) --
Levered Free Cash Flow (ttm) --

Institutional Holders (2026 Q2)

181 + investors

Explore institutional interest and hedge fund ownership dynamics. Analyze portfolio weights, new positions, and conviction trends in PRME. Verified SEC 13F-HR filings.

QUARTER:
Top 25 PRME holders by conviction (% of portfolio weight) — 2026 Q2 · Source: SEC Form 13F
# Investor % of Portfolio Shares Mkt Value
1 Alessandra Capital Management, LLC 1.74% 666,603 $2.5M
2 Chelsea Counsel Co 0.70% 449,060 $1.7M
3 Casdin Capital, LLC 0.58% 3,167,175 $11.7M
4 Green Alpha Advisors, LLC 0.46% 185,023 $683K
5 Redmile Group, LLC 0.34% 1,389,632 $5.1M
6 ADAR1 Capital Management, LLC 0.34% 1,997,552 $7.4M
7 ARK Investment Management LLC 0.20% 8,348,746 $30.8M
8 Amova Asset Management Americas, Inc. 0.11% 2,407,018 $8.9M
9 Virtus Investment Advisers, LLC 0.10% 117,909 $435K
10 IvyRock Asset Management (HK) Ltd 0.09% 41,800 $154K
11 Palumbo Wealth Management LLC 0.08% 103,801 $383K
12 Alphabet Inc. 0.06% 16,562,498 $61.1M
13 Milestone Asset Management, LLC 0.06% 100,035 $369K
14 IQ EQ FUND MANAGEMENT (IRELAND) Ltd 0.05% 225,799 $833K
15 Keystone Financial Group 0.04% 166,510 $614K
16 Woodline Partners LP 0.03% 3,003,904 $11.1M
17 Thompson Davis & CO., INC. 0.03% 14,590 $54K
18 Shelton Wealth Management, LLC 0.03% 19,105 $70K
19 Moore Capital Management, LP 0.03% 500,000 $1.8M
20 Balyasny Asset Management L.P. 0.02% 3,969,082 $14.6M
21 Blue Bell Private Wealth Management, LLC 0.01% 25,830 $95K
22 Abacus Planning Group, Inc. 0.01% 25,188 $93K
23 XTX Topco Ltd 0.01% 215,708 $796K
24 Profund Advisors LLC 0.01% 72,624 $268K
25 China Universal Asset Management Co., Ltd. 0.01% 28,745 $106K
Investor Ownership
History 		% of Portfolio Prev % Rank Conviction Avg Buy Price 13F Score™ 3Y / 7Y Sell Timing Shares Mkt Value Change Change % Source Quarter Filed

Frequently Asked Questions — Prime Medicine Inc (PRME)

What does the Smart Money Trend signal show for PRME?

Selling streak — 1 quarter in a row: For 1 consecutive quarter, more hedge funds reduced or closed their PRME positions than added to them. Sustained institutional selling is a meaningful warning sign — these are professionals with deep research teams collectively deciding to exit.

What is the institutional breadth score for PRME?

More sellers than buyers — 48% buying: Last quarter: 97 funds reduced or exited vs 89 that bought or added. When more than half of active funds are selling, it's a caution flag — especially if the stock price hasn't moved down yet.

What is the fund quality score for PRME holders?

Elite ownership — 61% AUM from top-100 funds: 46 of 183 holders are among the 100 largest funds by AUM, controlling 61% of total institutional value in PRME. When the biggest players dominate the cap table, it signifies deep institutional support — since mega-funds deploy the most rigorous due diligence and capital.

How long have hedge funds held PRME?

Mixed — 37% long-term, 29% new: Of the 184 current holders: 68 (37%) held >2 years, 63 held 1–2 years, and 53 entered in the last year. A mixed base — the stock has long-term believers but also recent buyers who haven't been tested by a downturn yet.

Where does this institutional ownership data come from?

All holdings data is sourced from SEC Form 13F filings, which institutional investment managers with over $100 million in assets are required to submit quarterly. Data is parsed directly from SEC EDGAR.

Disclaimer: The information on this page is for informational purposes only and does not constitute investment advice, a recommendation, or an offer to buy or sell any security. Institutional holdings data is sourced from SEC Form 13F filings and reflects positions as of the filing date. Past performance of any fund or portfolio is not indicative of future results. 13Foresight is not a registered investment adviser. Always conduct your own due diligence before making investment decisions.

Full history →