Stock Analysis
Data Source: SEC EDGAR 13F
Updated Hourly

Prime Medicine Inc (PRME)

187 + Investors. Track Smart Money conviction in PRME. See who's accumulating, reducing, or initiating positions.

Current Price
-- USD
Analyst Target
-- (0 analysts)
Upside
0.00%
Net Flow Q/Q
↑ +7
Streak
3Q ▲
Buyers last Q
58%

Smart Money Signals — PRME

Based on 188 hedge funds · latest filing: 2026 Q1 · updated quarterly

📈

Buying streak — 3 quarters in a row

last 6Q
For 3 consecutive quarters, more hedge funds added PRME than sold it. That's a consistent pattern of professional buying — not a one-time trade. When institutions keep buying quarter after quarter, it usually means they see a multi-year opportunity, not just a short-term momentum flip.
🏔️

At the ownership peak (100% of max)

100% of all-time peak
188 hedge funds hold PRME right now — the highest count in 3.0 years. When ownership is this concentrated, any bad news can trigger a chain reaction: one big fund sells, others follow. This is a classic 'crowded trade' — high popularity doesn't equal safety.
🚀

Fast accumulation — +54% more funds vs a year ago

fund count last 6Q
+66 new funds entered over the past year (+54% YoY). That's a rapid rush of institutional money. Fast accumulation often signals a major thesis — but it also means the stock could fall quickly if that thesis breaks.
🟡

Slight buying edge — 58% buying

112 buying80 selling
Last quarter: 112 funds bought or added vs 80 that reduced or exited. It's nearly a 50/50 split — some institutions are convinced, others are taking profits. This mixed picture is normal near price highs.
⚠️

Fewer new buyers each quarter (-9 vs last Q)

new funds entering per quarter
Funds opening this position for the first time: 28 → 50 → 47 → 38. Each quarter fewer new institutions are entering. This usually means most funds that wanted in are already in — the stock is well-known but the pool of potential new buyers is shrinking.
📌

Mixed — 32% long-term, 39% new

■ 32% conviction (2yr+) ■ 28% medium ■ 39% new
Of the 188 current holders: 61 (32%) held >2 years, 53 held 1–2 years, and 74 entered in the last year. A mixed base — the stock has long-term believers but also recent buyers who haven't been tested by a downturn yet.
➡️

Steady discovery — ~38 new funds/quarter

22 → 28 → 50 → 47 → 38 new funds/Q
New funds entering each quarter: 28 → 50 → 47 → 38. Consistent flow of new institutional buyers without clear acceleration or slowdown.
📊

Mixed cohorts — 37% veterans, 45% new entrants

■ 37% veterans ■ 18% 1-2yr ■ 45% new
Of 193 current holders: 72 (37%) held 2+ years, 34 held 1–2 years, 87 (45%) entered in the past year. Balanced distribution — some institutional memory, some recent momentum buyers.
✅

Strong quality — 30% AUM from major funds

30% from top-100 AUM funds
43 of 188 holders rank in the top 100 by AUM, accounting for 30% of total institutional value held. A meaningful share of the ownership value comes from the most well-resourced institutions.
4.7
out of 10
Moderate Exit Risk
Exit risk score 4.7/10 — some crowding factors present, but no critical concentration. Watch ownership trend over the next 1–2 quarters for direction.

Methodology note: these Smart Money cards use consecutive 13F disclosure snapshots, not trade-by-trade execution data. "Buying", "selling", "new holders", and "trimmed" refer to quarter-over-quarter changes in reported holders, aggregate shares, or disclosed position values between filings. They are useful for ownership regime analysis and crowding, but they do not imply exact trade timing on the filing date.

Institutional Sentiment Summary — PRME

In 2026 Q1, 112 hedge funds were net buyers of PRME (38 opened a new position, 74 added to an existing one), while 80 reduced or exited (49 trimmed, 31 sold completely) — a 58% buyer ratio, indicating a slight buying edge. This marks 3 consecutive quarters of net institutional buying — a persistent conviction signal. 30% of total institutional value in PRME is held by top-100 AUM funds, reflecting strong institutional quality. Net fund flow last quarter: +7 funds (more new holders than closures). Total institutional holders: 188.

Hedge Fund Ownership: PRME

How many hedge funds hold PRME — quarterly history vs. share price
Quarterly hedge fund ownership of PRME vs. share price

Market Analysis: PRME

Analyst Price Targets

Avg. Price Target
--

Analyst Recommendations

Stock Performance

Real-time

Company Profile: PRME

-- --

Institutional ownership data sourced from SEC EDGAR Form 13F-HR filings.

Is It Too Late to Buy Prime Medicine Inc (PRME) Based on Hedge Fund 13F Filings?

Signal Freshness measures how much PRME has moved relative to its sector benchmark (XLV) since the 2026 Q1 13F filing. A stock that has barely outrun its sector is still a relatively fresh entry point — the fund's thesis has not yet been priced in by the broader market.

Since Quarter End March 31, 2026 · 75d ago
PRME
-20.3%
XLV
+4.9%

PRME outperformed XLV by -25.2% since March 31, 2026.

Since 13F Filing Date May 15, 2026 · 30d ago
PRME
-5.3%
XLV
+6.0%

Since the filing became public, PRME outperformed XLV by -11.3% .

Interpretation: The stock is tracking its sector benchmark closely. The signal remains fresh and the entry point is still near the fund's implied reference. Learn more →

Smart Money Signal ?
Limited Smart Money Interest

No strong consensus or elite conviction detected among institutional holders.

22 top-rated funds 1 high-conviction
Consensus
5.9
/ 10
breadth
×
Elite
1.1
/ 10
conviction
Hedge Fund Positioning: PRME
187 + Investors

Track Smart Money conviction in PRME. See who's accumulating, reducing, or initiating positions.

Metric All 13F Filers (2026 Q1) Prior (2025 Q4) Change
Funds Holding 187 181 3.31%
13F Shares 99M 93M 5.63%
Total Value $321M $324M -0.92%
New Positions 37 47 -10
Increased Positions 73 62 +11
Closed Positions 31 28 +3
Reduced Positions 48 42 +6
Total Calls 3 5 -40.0%
Total Puts 3 3 -
PUT/CALL Ratio 1.0 0.6 Neutral

Statistics: PRME

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Valuation Measures Data as of: --

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Enterprise Value/EBITDA --
Beta (5Y Monthly) --
Short Ratio (Days to Cover) --
Short % of Float --

Financial Highlights

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Institutional Holders (2026 Q1)

187 + investors

Explore institutional interest and hedge fund ownership dynamics. Analyze portfolio weights, new positions, and conviction trends in PRME. Verified SEC 13F-HR filings.

QUARTER:
Top 25 PRME holders by conviction (% of portfolio weight) — 2026 Q1 · Source: SEC Form 13F
# Investor % of Portfolio Shares Mkt Value
1 Alphabet Inc. 1.44% 16,562,498 $57.6M
2 Casdin Capital, LLC 0.83% 3,167,175 $11.0M
3 Green Alpha Advisors, LLC 0.66% 191,171 $665K
4 ADAR1 Capital Management, LLC 0.40% 1,973,282 $6.9M
5 Redmile Group, LLC 0.37% 1,590,832 $5.5M
6 Elevate Capital Advisors, LLC 0.34% 151,069 $526K
7 Chelsea Counsel Co 0.34% 227,000 $788K
8 ARK Investment Management LLC 0.17% 6,246,827 $21.7M
9 Amova Asset Management Americas, Inc. 0.14% 2,940,793 $10.2M
10 Palumbo Wealth Management LLC 0.09% 102,246 $356K
11 IvyRock Asset Management (HK) Ltd 0.08% 41,800 $145K
12 Virtus Investment Advisers, LLC 0.06% 66,508 $231K
13 VARCOV Co. 0.05% 41,964 $146K
14 IQ EQ FUND MANAGEMENT (IRELAND) Ltd 0.05% 205,389 $715K
15 Scientech Research LLC 0.05% 17,931 $62K
16 Thompson Davis & CO., INC. 0.04% 17,240 $60K
17 Keystone Financial Group 0.04% 166,010 $578K
18 Woodline Partners LP 0.04% 3,003,313 $10.5M
19 Moore Capital Management, LP 0.04% 500,000 $1.7M
20 Shelton Wealth Management, LLC 0.03% 20,066 $70K
21 Rhodes Investment Advisors Inc /Adv 0.03% 10,750 $37K
22 Farallon Capital Management LLC 0.02% 1,240,843 $4.3M
23 Balyasny Asset Management L.P. 0.02% 4,123,365 $14.3M
24 Axq Capital, LP 0.02% 36,742 $128K
25 Blue Bell Private Wealth Management, LLC 0.01% 27,015 $94K
Investor Ownership
History 		% of Portfolio Prev % Rank Conviction Avg Buy Price 13F Score™ 3Y / 7Y Sell Timing Shares Mkt Value Change Change % Source Quarter Filed

Frequently Asked Questions — Prime Medicine Inc (PRME)

What does the Smart Money Trend signal show for PRME?

Buying streak — 3 quarters in a row: For 3 consecutive quarters, more hedge funds added PRME than sold it. That's a consistent pattern of professional buying — not a one-time trade. When institutions keep buying quarter after quarter, it usually means they see a multi-year opportunity, not just a short-term momentum flip.

What is the institutional breadth score for PRME?

Slight buying edge — 58% buying: Last quarter: 112 funds bought or added vs 80 that reduced or exited. It's nearly a 50/50 split — some institutions are convinced, others are taking profits. This mixed picture is normal near price highs.

What is the fund quality score for PRME holders?

Strong quality — 30% AUM from major funds: 43 of 188 holders rank in the top 100 by AUM, accounting for 30% of total institutional value held. A meaningful share of the ownership value comes from the most well-resourced institutions.

How long have hedge funds held PRME?

Mixed — 32% long-term, 39% new: Of the 188 current holders: 61 (32%) held >2 years, 53 held 1–2 years, and 74 entered in the last year. A mixed base — the stock has long-term believers but also recent buyers who haven't been tested by a downturn yet.

Is it too late to buy Prime Medicine Inc (PRME) following the 2026 Q1 hedge fund 13F filings?

As of today, PRME has moved -5.3% since the 2026 Q1 13F filing date (May 15, 2026), compared to +6.0% for the XLV sector ETF — an outperformance of -11.3%. Since the quarter end (March 31, 2026), PRME has gained -20.3% vs +4.9% for XLV. The stock is tracking its sector benchmark closely. The signal remains fresh and the entry point is still near the fund's implied reference.

Where does this institutional ownership data come from?

All holdings data is sourced from SEC Form 13F filings, which institutional investment managers with over $100 million in assets are required to submit quarterly. Data is parsed directly from SEC EDGAR.

Disclaimer: The information on this page is for informational purposes only and does not constitute investment advice, a recommendation, or an offer to buy or sell any security. Institutional holdings data is sourced from SEC Form 13F filings and reflects positions as of the filing date. Past performance of any fund or portfolio is not indicative of future results. 13Foresight is not a registered investment adviser. Always conduct your own due diligence before making investment decisions.

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