Stock Analysis
Data Source: SEC EDGAR 13F
Updated Hourly

Agios Pharmaceuticals Inc (AGIO)

231 + Investors. Track Smart Money conviction in AGIO. See who's accumulating, reducing, or initiating positions.

Current Price
-- USD
Analyst Target
-- (0 analysts)
Upside
0.00%
Net Flow Q/Q
↓ -3
Streak
1Q ▼
Buyers last Q
51%

Smart Money Signals — AGIO

Based on 232 hedge funds · latest filing: 2026 Q1 · updated quarterly

📉

Selling streak — 1 quarter in a row

last 6Q
For 1 consecutive quarter, more hedge funds reduced or closed their AGIO positions than added to them. Sustained institutional selling is a meaningful warning sign — these are professionals with deep research teams collectively deciding to exit.
🏔️

At the ownership peak (99% of max)

99% of all-time peak
232 hedge funds hold AGIO right now — the highest count in 3.0 years. When ownership is this concentrated, any bad news can trigger a chain reaction: one big fund sells, others follow. This is a classic 'crowded trade' — high popularity doesn't equal safety.
📶

Steady growth — +8% more funds vs a year ago

fund count last 6Q
+17 new funds entered over the past year (+8% YoY). Gradual, steady growth in institutional ownership is generally a healthy signal — not a speculative rush, but consistent conviction.
🟡

Slight buying edge — 51% buying

125 buying120 selling
Last quarter: 125 funds bought or added vs 120 that reduced or exited. It's nearly a 50/50 split — some institutions are convinced, others are taking profits. This mixed picture is normal near price highs.
⚠️

Fewer new buyers each quarter (-29 vs last Q)

new funds entering per quarter
Funds opening this position for the first time: 24 → 45 → 64 → 35. Each quarter fewer new institutions are entering. This usually means most funds that wanted in are already in — the stock is well-known but the pool of potential new buyers is shrinking.
🔒

61% of holders stayed for 2+ years

■ 61% conviction (2yr+) ■ 21% medium ■ 18% new
142 out of 232 hedge funds have held AGIO for over 2 years without selling. Long-term investors are generally harder to shake out during market stress, creating a stable ownership base that limits the risk of sudden capitulation.
💰

Price up while funds trimmed (+18% value, -1% shares)

Value
+17%
Shares
0%
Last quarter: total value of institutional AGIO holdings rose +18% even though funds reduced share count by 1%. The stock price increased enough to offset the selling. Institutions are quietly trimming into price strength — watch for rotation.
📈

Growing discovery — still being found

37 → 24 → 45 → 64 → 35 new funds/Q
New funds entering each quarter: 24 → 45 → 64 → 35. A growing number of institutions are discovering AGIO each quarter. The narrative is still spreading — leaving room for ongoing capital accumulation.
🏛️

Veteran-anchored — 68% veterans vs 20% newcomers

■ 68% veterans ■ 13% 1-2yr ■ 20% new
Entry-cohort mix of 245 holders: 166 (68%) are 2+ year veterans, 31 entered 1–2 years ago, and 48 (20%) joined within the past year. A veteran-weighted cap table skews toward institutional memory over fresh momentum.
✅

Strong quality — 30% AUM from major funds

30% from top-100 AUM funds
46 of 229 holders rank in the top 100 by AUM, accounting for 30% of total institutional value held. A meaningful share of the ownership value comes from the most well-resourced institutions.
3.6
out of 10
Low Exit Risk
Exit risk score 3.6/10 — low institutional crowding. Ownership is below peak levels, holder base is relatively sticky, and buying momentum is positive.

Methodology note: these Smart Money cards use consecutive 13F disclosure snapshots, not trade-by-trade execution data. "Buying", "selling", "new holders", and "trimmed" refer to quarter-over-quarter changes in reported holders, aggregate shares, or disclosed position values between filings. They are useful for ownership regime analysis and crowding, but they do not imply exact trade timing on the filing date.

Institutional Sentiment Summary — AGIO

In 2026 Q1, 125 hedge funds were net buyers of AGIO (35 opened a new position, 90 added to an existing one), while 120 reduced or exited (82 trimmed, 38 sold completely) — a 51% buyer ratio, indicating a slight buying edge. 30% of total institutional value in AGIO is held by top-100 AUM funds, reflecting strong institutional quality. Net fund flow last quarter: -3 funds (more exits than new entries). Total institutional holders: 232.

Hedge Fund Ownership: AGIO

How many hedge funds hold AGIO — quarterly history vs. share price
Quarterly hedge fund ownership of AGIO vs. share price

Market Analysis: AGIO

Analyst Price Targets

Avg. Price Target
--

Analyst Recommendations

Stock Performance

Real-time

Company Profile: AGIO

-- --

Institutional ownership data sourced from SEC EDGAR Form 13F-HR filings.

Is It Too Late to Buy Agios Pharmaceuticals Inc (AGIO) Based on Hedge Fund 13F Filings?

Signal Freshness measures how much AGIO has moved relative to its sector benchmark (XLV) since the 2026 Q1 13F filing. A stock that has barely outrun its sector is still a relatively fresh entry point — the fund's thesis has not yet been priced in by the broader market.

Since Quarter End March 31, 2026 · 75d ago
AGIO
-12.9%
XLV
+4.9%

AGIO outperformed XLV by -17.8% since March 31, 2026.

Since 13F Filing Date May 15, 2026 · 30d ago
AGIO
+4.6%
XLV
+6.0%

Since the filing became public, AGIO outperformed XLV by -1.4% .

Interpretation: The stock is tracking its sector benchmark closely. The signal remains fresh and the entry point is still near the fund's implied reference. Learn more →

Smart Money Signal ?
Limited Smart Money Interest

No strong consensus or elite conviction detected among institutional holders.

26 top-rated funds 5 high-conviction
Consensus
6.2
/ 10
breadth
×
Elite
2.8
/ 10
conviction
Hedge Fund Positioning: AGIO
231 + Investors

Track Smart Money conviction in AGIO. See who's accumulating, reducing, or initiating positions.

Metric All 13F Filers (2026 Q1) Prior (2025 Q4) Change
Funds Holding 231 235 -1.7%
13F Shares 67M 67M -0.66%
Total Value $2.14B $1.81B 17.88%
New Positions 34 64 -30
Increased Positions 81 78 +3
Closed Positions 38 51 -13
Reduced Positions 82 70 +12
Total Calls 10 13 -23.08%
Total Puts 6 7 -14.29%
PUT/CALL Ratio 0.6 0.54 Bullish

Statistics: AGIO

View More

Valuation Measures Data as of: --

Market Cap --
Enterprise Value --
Trailing P/E --
Forward P/E --
PEG Ratio (5yr expected) --
Price/Sales (ttm) --
Price/Book (mrq) --
Enterprise Value/Revenue --
Enterprise Value/EBITDA --
Beta (5Y Monthly) --
Short Ratio (Days to Cover) --
Short % of Float --

Financial Highlights

Profitability
Profit Margin --
Return on Assets (ttm) --
Return on Equity (ttm) --
Income Statement & Cash Flow
Revenue (ttm) --
Net Income Avi to Common (ttm) --
Diluted EPS (ttm) --
Total Cash (mrq) --
Total Debt/Equity (mrq) --
Levered Free Cash Flow (ttm) --

Institutional Holders (2026 Q1)

231 + investors

Explore institutional interest and hedge fund ownership dynamics. Analyze portfolio weights, new positions, and conviction trends in AGIO. Verified SEC 13F-HR filings.

QUARTER:
Top 25 AGIO holders by conviction (% of portfolio weight) — 2026 Q1 · Source: SEC Form 13F
# Investor % of Portfolio Shares Mkt Value
1 Lynx1 Capital Management LP 13.96% 2,611,568 $88.3M
2 Foresite Capital Management VI LLC 3.86% 525,000 $17.8M
3 MPM BioImpact LLC 3.41% 1,306,261 $44.2M
4 Seven Fleet Capital Management LP 2.25% 209,547 $7.1M
5 Exome Asset Management LLC 2.19% 125,060 $4.2M
6 Armistice Capital, LLC 1.92% 3,200,000 $108.3M
7 Knott David M Jr 1.87% 93,058 $3.1M
8 Armistice Capital, LLC 1.63% 2,716,000 $91.9M
9 Rock Springs Capital Management LP 1.59% 799,163 $27.0M
10 Parkman Healthcare Partners LLC 1.41% 403,525 $13.7M
11 Palo Alto Investors LP 1.11% 213,601 $7.2M
12 Farallon Capital Management LLC 1.10% 5,684,000 $192.3M
13 Frazier Life Sciences Management, L.P. 1.09% 1,256,080 $42.5M
14 Tetragon Partners GP Ltd 1.08% 164,839 $5.6M
15 Erste Asset Management GmbH 0.74% 2,704,900 $80.1M
16 Ground Swell Capital, LLC 0.56% 8,347 $282K
17 Essex Investment Management Co LLC 0.55% 103,177 $3.5M
18 AlphaCentric Advisors LLC 0.47% 13,971 $473K
19 Vestal Point Capital, LP 0.43% 450,000 $15.2M
20 ArrowMark Colorado Holdings LLC 0.36% 403,590 $13.7M
21 PSP Research LLC 0.36% 15,000 $507K
22 Eversept Partners, LP 0.36% 200,000 $6.8M
23 Virtus Investment Advisers, LLC 0.29% 30,959 $1.0M
24 ADAR1 Capital Management, LLC 0.28% 140,672 $4.8M
25 Headlands Technologies LLC 0.23% 59,257 $2.0M
Investor Ownership
History 		% of Portfolio Prev % Rank Conviction Avg Buy Price 13F Score™ 3Y / 7Y Sell Timing Shares Mkt Value Change Change % Source Quarter Filed

Frequently Asked Questions — Agios Pharmaceuticals Inc (AGIO)

What does the Smart Money Trend signal show for AGIO?

Selling streak — 1 quarter in a row: For 1 consecutive quarter, more hedge funds reduced or closed their AGIO positions than added to them. Sustained institutional selling is a meaningful warning sign — these are professionals with deep research teams collectively deciding to exit.

What is the institutional breadth score for AGIO?

Slight buying edge — 51% buying: Last quarter: 125 funds bought or added vs 120 that reduced or exited. It's nearly a 50/50 split — some institutions are convinced, others are taking profits. This mixed picture is normal near price highs.

What is the fund quality score for AGIO holders?

Strong quality — 30% AUM from major funds: 46 of 229 holders rank in the top 100 by AUM, accounting for 30% of total institutional value held. A meaningful share of the ownership value comes from the most well-resourced institutions.

How long have hedge funds held AGIO?

61% of holders stayed for 2+ years: 142 out of 232 hedge funds have held AGIO for over 2 years without selling. Long-term investors are generally harder to shake out during market stress, creating a stable ownership base that limits the risk of sudden capitulation.

Is it too late to buy Agios Pharmaceuticals Inc (AGIO) following the 2026 Q1 hedge fund 13F filings?

As of today, AGIO has moved +4.6% since the 2026 Q1 13F filing date (May 15, 2026), compared to +6.0% for the XLV sector ETF — an outperformance of -1.4%. Since the quarter end (March 31, 2026), AGIO has gained -12.9% vs +4.9% for XLV. The stock is tracking its sector benchmark closely. The signal remains fresh and the entry point is still near the fund's implied reference.

Where does this institutional ownership data come from?

All holdings data is sourced from SEC Form 13F filings, which institutional investment managers with over $100 million in assets are required to submit quarterly. Data is parsed directly from SEC EDGAR.

Disclaimer: The information on this page is for informational purposes only and does not constitute investment advice, a recommendation, or an offer to buy or sell any security. Institutional holdings data is sourced from SEC Form 13F filings and reflects positions as of the filing date. Past performance of any fund or portfolio is not indicative of future results. 13Foresight is not a registered investment adviser. Always conduct your own due diligence before making investment decisions.

Full history →